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Not yet recruitingOBSERVATIONAL

TransThoracic Ultrasound for Descending Aortic Aneurysms

This study aims to find out if a simple ultrasound scan can effectively check for swellings (aneurysms) in a specific part of the main artery in your chest, called the descending thoracic aorta. Currently, doctors often use X-ray-based scans, which involve radiation and can be expensive. Ultrasound is much safer and easier to use. This research will compare ultrasound results with existing X-ray scans to see how accurate and reliable ultrasound is for finding and measuring these aneurysms. If successful, ultrasound could become a routine, safer way to monitor this important health issue.

At a glance

Status
Not yet recruiting
Sponsor
Imperial College London
Enrolment target
60
Start
07 Sep 2026
Estimated completion
03 Apr 2028

What is this study about?

Imagine the main blood vessel leaving your heart, called the aorta. It's like a large pipe that carries blood to the rest of your body. Sometimes, a part of this pipe can weaken and balloon out, which is called an aneurysm. While doctors regularly check other parts of this pipe using ultrasound, a section that runs down your chest (called the descending thoracic aorta) is usually checked with X-ray-based scans. These X-ray scans use a small amount of radiation and can be quite costly.

This study wants to see if we can use a simpler, safer method – ultrasound – to look at this particular section of the aorta. Ultrasound uses sound waves, not radiation, to create pictures of what's inside your body. The aim is to find out if ultrasound can clearly see this part of the aorta, if it can accurately measure the size of any aneurysms, and if it gives consistent results when scans are done multiple times. This could lead to a less invasive and more accessible way to monitor this condition.

Ultimately, if ultrasound proves to be a good tool for checking the descending thoracic aorta, it could mean that patients might need fewer X-ray scans in the future. This could make monitoring easier, safer, and potentially cheaper, benefitting many people. We're hoping to show that this widely available technology can be used for a new important purpose.

Key takeaways

  • The study explores using safe ultrasound instead of X-ray scans for chest artery swellings.
  • It checks if ultrasound can accurately find and measure these swellings.
  • Participation involves one extra, painless ultrasound scan.
  • Your standard medical care remains exactly the same.
  • This research could lead to easier and safer monitoring for patients in the future.

Who may be eligible?

To join this study, you need to be an adult, aged 18 or older. We are looking for two main groups of people: those who already have a swelling (aneurysm) in their descending thoracic aorta, or those who have had a procedure for it, and a control group who have healthy descending thoracic aortas but may have other blood vessel conditions.

It's important that you've already had a CT scan of your chest aorta as part of your regular medical care. You also need to be able to lie flat for the ultrasound scan and be willing to give your permission to take part. Unfortunately, we can't include people who are under 18, pregnant, or have certain health issues like severe curving of the spine, previous chest surgery, or a very short life expectancy. Also, if you can't come to appointments or have certain rare reasons why an ultrasound might not be suitable, you wouldn't be able to join.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you 18 years old or older?
  2. Have you had a CT scan of your chest aorta recently?
  3. Can you lie flat for a short scan?
  4. Are you not pregnant?
  5. Do you not have severe spine curving or previous chest surgery?
  6. Are you willing to give permission to take part?
Answer every question to see your result.

What does participation involve?

If you decide to take part, you won't receive any new treatments or medications. You'll continue to get your usual medical care exactly as you would normally. The only extra step is an additional ultrasound scan of your chest. This scan is quick and painless, and you'll lie down for it. We will then compare the measurements from this ultrasound with the results from the CT scans you've already had as part of your standard care. The total duration of your participation will involve attending this one extra ultrasound appointment.

Potential risks and benefits

Taking part in this study carries very little risk, as ultrasound is a safe and painless procedure with no radiation involved. You'll continue to receive your standard medical care, so your health will not be impacted negatively. The main benefit is that you'd be helping us find a potentially safer and easier way to check for aneurysms in the future, which could help many patients. Remember, you can decide to stop taking part in the study at any time, without giving a reason, and your medical care will not be affected.

Locations (1)

  • Imperial College Healthcare NHS Trust - St Mary's Hospital
    Verified postcode
    London, United Kingdom

Common questions

What is an aneurysm?

An aneurysm is a bulge or swelling in a blood vessel, like a weak spot in a pipe. It can be serious if it gets too big or bursts.

What is the descending thoracic aorta?

It's the main artery that carries blood from your heart, and this specific part runs down through your chest.

Is ultrasound safe?

Yes, ultrasound is very safe. It uses sound waves, not X-rays or radiation, to create pictures inside your body.

Will I get any special treatment?

No, you'll continue to receive your usual medical care. This study just adds an extra ultrasound scan to compare with your existing scans.

Do I have to take part?

No, taking part is completely your choice. Your medical care won't change if you decide not to join.

How to find out more

Carlos Pinho, PhD Student

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "TransThoracic Ultrasound for Descending Aortic Aneurysms…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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