Ongoing, recruitingTherapeutic exploratory (Phase II)Interventional

Glucagon enhanced insulin absorption in Diabetes Mellitus type 1

This research is investigating how a hormone called glucagon might improve insulin absorption in people living with type 1 diabetes. Researchers want to see if giving glucagon helps insulin work more effectively to control blood sugar. The study will measure how blood sugar levels change in the first hour after insulin and glucagon are given. They'll also look at how insulin and glucagon levels change in the body over three hours. This is an early phase study, meaning it's exploring new ideas rather than testing a final treatment. The goal is to understand how these hormones interact and if this approach could be a helpful way to manage type 1 diabetes in the future.

At a glance

Status

Ongoing, recruiting

Phase

Therapeutic exploratory (Phase II)

Sponsor

St. Olavs Hospital HF

Enrolment target

Start

29 Mar 2023

Diabetes mellitus type 1

What is this study about?

This study is exploring a new idea for people with Type 1 Diabetes. We know that in Type 1 Diabetes, the body doesn't produce enough insulin, which is needed to control blood sugar. This research is looking at whether giving a hormone called glucagon could help the insulin that people already take work better.

Think of it like this: insulin helps transfer sugar from your blood into your cells. This study wants to see if glucagon can act as a helper, making that transfer happen more smoothly and quickly, especially in the first hour after you take your insulin. By making insulin absorb better, it might lead to more stable blood sugar levels.

The main goal is to carefully measure how blood sugar changes in the first hour after someone receives both insulin and glucagon. Researchers will also be looking at detailed information about how insulin and glucagon move through the body over three hours. This is an exploratory study, meaning it's a first step to see if this idea has potential. If successful, it could lead to new ways to help people with Type 1 Diabetes manage their condition more effectively.

Key takeaways

Exploring if glucagon can help insulin work better for Type 1 Diabetes.
Focuses on how blood sugar and hormones change over a few hours.
This is an early-stage, exploratory study.
Aims to gather important information for future diabetes treatments.
Open to adults aged 18 and over, both men and women.

Who may be eligible?

To be able to take part in this study, participants must be at least 18 years old. There is no upper age limit, meaning older adults are also welcome to join.

Both men and women are invited to take part in this research.

Specific medical details will be checked by the study team to make sure it's safe and appropriate for you to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have Type 1 Diabetes?
Are you comfortable with multiple blood draws?
Are you able to commit to several study visits?

Answer every question to see your result.

What does participation involve?

Taking part in this study would involve a few visits to the research clinic. During these visits, you would receive the study medication (glucagon) along with your regular insulin. Researchers would then take blood samples at set times over a few hours to measure your blood sugar, insulin, and glucagon levels. They will also use special cameras to measure skin temperature and blood flow. The total duration of your participation would involve these study visits and any necessary follow-up checks, which will be explained in full detail by the study team.

Potential risks and benefits

Potential benefits could include contributing to new knowledge about managing Type 1 Diabetes, which may improve future treatments. While this is an early-stage study, it's hoped that the information gathered could one day lead to better insulin absorption. Potential risks might include discomfort from blood draws, or side effects from glucagon, which would be explained thoroughly by the study team. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Norway

Common questions

What is glucagon?

Glucagon is a natural hormone your body makes that usually raises blood sugar. In this study, we're looking at whether a dose of glucagon might help insulin work better.

What is Type 1 Diabetes?

Type 1 Diabetes is a condition where your body doesn't make insulin, a hormone essential for controlling blood sugar. People with Type 1 Diabetes need to take insulin daily.

What does 'early-phase' study mean?

An early-phase study means we're still exploring a new idea or treatment. It's about understanding how something works and if it's safe, rather than proving it's a cure.

Will this study benefit me directly?

While this study aims to improve future treatments, there's no guarantee of direct personal benefit now. You'll be helping us learn more about Type 1 Diabetes management.

What are 'pharmacokinetic estimates'?

This refers to how your body absorbs, distributes, breaks down, and removes a medication like insulin or glucagon. It helps us understand how the medicine moves through your system.