Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

This study is looking for women aged 18 or older who have recently had surgery to remove their womb and ovaries for early-stage womb cancer. Your cancer must be one of the specific types they are studying (POLE-mutated or p53 wildtype/NSMP). You should also be well enough to carry out your normal daily activities.

There are some reasons why you might not be able to join. For example, if you've already had radiation treatment in your pelvic area, or if your cancer has spread to other parts of your body, this study might not be suitable. Also, if there's still visible cancer remaining after your surgery, or if parts of your cancer cells are found in certain fluid washes, you wouldn't be able to participate. They also can't include you if you've had certain other cancers recently.

All participants will need to give their informed consent, meaning you understand the study and agree to take part. You also need to be able to complete questionnaires in English, French, or another available language, and be able to attend follow-up appointments at the participating hospital.

If you join this study, your involvement would begin within 10 weeks of your surgery. You might be asked to have vaginal brachytherapy (a type of internal radiation), external beam radiation therapy, or you might be placed in a group where doctors simply observe you closely without further treatment, depending on which sub-study you join and what is agreed upon. The specific treatments and follow-up plan will be thoroughly explained to you.

Throughout the study, you'll have regular hospital visits for check-ups and to monitor your health and recovery. You may also be asked to fill in questionnaires about how you are feeling and your quality of life. The total duration of your participation, including treatment and follow-up, will be detailed by the study team.