Active not recruitingOBSERVATIONAL

Biomarkerscreening in Cervical Cancer and Its Preinvasive Lesions

This research is happening in Germany and focuses on cervical health, specifically looking at changes in the cervix caused by the Human Papillomavirus (HPV) that might lead to cancer. The main goal is to find new 'biomarkers' – these are like early warning signs in the body – within tissue samples. By studying these markers, scientists hope to better understand which cervical changes are more likely to become serious. They are collecting fresh tissue during routine procedures like conization or hysterectomy. The information gathered could eventually help develop new, more accurate tests to predict the risk of cervical cancer, making it easier to decide who needs closer monitoring or treatment.

At a glance

Status

Active not recruiting

Sponsor

University of Luebeck

Enrolment target

100

Start

01 Sep 2014

Estimated completion

01 Dec 2030

Evaluation of New Tissue Biomarkers for Cervical Cancer

What is this study about?

This study is an important piece of research happening in Germany, led by medical experts from the University of Luebeck and a national research center. The main focus is on how Human Papillomavirus (HPV) affects the cervix – the lower part of the womb. We know that certain types of HPV can cause changes in the cells of the cervix, which, if left unchecked, can sometimes lead to cervical cancer.

The researchers are trying to find new ways to identify these changes early and understand which ones are most likely to develop into cancer. They're doing this by looking very closely at tissue samples taken from patients. They are particularly interested in finding 'biomarkers,' which are specific clues within the body's cells that can indicate disease or a risk of disease. By studying these clues, they hope to get a clearer picture of which HPV-related changes are concerning and which are not.

Ultimately, the big picture for this project is to use what they learn to create better tests. Imagine a new test that could tell doctors more accurately if a cervical change caused by HPV is something that needs treatment, or if it's likely to clear up on its own. This could lead to more personalised care and help prevent cervical cancer from developing, by focusing on those who truly need intervention.

Key takeaways

This study aims to find better ways to detect and prevent cervical cancer.
It focuses on changes in the cervix linked to the HPV virus.
Researchers are looking for 'biomarkers' in tissue samples.
The goal is to develop improved tests for predicting cancer risk.
Participation involves donating tissue already removed during routine procedures.
Your medical care is not affected by taking part.

Who may be eligible?

This study is looking for women who are already undergoing procedures for suspected or confirmed changes in their cervix, whether these are very early (pre-cancerous) or actual cancer.

You would be considered for this study if your doctor at the University of Luebeck's gynaecology department thinks you might have a pre-cancerous lesion, or if you have already been diagnosed with either pre-cancerous changes or cervical cancer.

To join, you'll need to give your clear agreement (called 'informed consent') and be able to provide all the necessary medical information. If any of your key information is missing, or if you don't wish to give consent, then you wouldn't be able to take part in this particular study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you having a procedure (like a conization or hysterectomy) for suspected or confirmed cervical changes?
Has your doctor at the University of Luebeck's gynaecology department discussed this study with you?
Are you willing and able to give your informed consent?
Can all your relevant medical information be collected for the study?

Answer every question to see your result.

What does participation involve?

As this study uses tissue samples that are already being removed during your planned medical procedures, like a conization or hysterectomy, there aren't any extra visits or assessments for you. You won't be taking any extra medication as part of this research. The study uses the tissue ethically after it has been removed for your medical care. There is no specific follow-up related to the study itself, beyond your standard medical care.

Potential risks and benefits

There are no additional risks to you for taking part in this study, as it uses tissue that is already being removed as part of your normal medical care. The potential benefit is that the information gained from studying your tissue, along with many others, could help scientists develop better ways to predict and prevent cervical cancer in the future, helping many women. You always have the right to withdraw your consent for your tissue to be used for research at any time, without it affecting your medical care.

Locations (1)

Luebeck University, Department for obstetrics and gynecology
Verified postcode
Lübeck, Germany

Common questions

What is HPV and why is it important?

HPV, or Human Papillomavirus, is a very common virus. Some types can cause changes in the cells of the cervix, which can sometimes lead to cervical cancer if not treated. This study aims to understand these changes better.

What is a 'biomarker'?

Think of a biomarker as a 'clue' in your body, like a special protein or genetic change, that can tell doctors something about your health, such as finding a disease early or how it might progress.

Will taking part in this study change my medical treatment?

No, taking part in this study will not change your medical treatment. This research uses tissue that is already being removed for your care; it doesn't involve any extra procedures or medicines for you.

Who is running this study?

This study is being run by medical experts from the University of Luebeck and a national research center in Germany.

Will I get results from this study about my own tissue?

The information from this research is for studying groups of samples to find general patterns. You will not receive individual results about the specific findings from your tissue sample.