RecruitingOBSERVATIONAL

Study on Hydrotalcite for Relief of Acid Symptoms Due to Acid Rebound After Stopping Long-Term PPI Therapy

This study is investigating hydrotalcite, sold as Talcid, to see how well it helps people who experience acid reflux symptoms like heartburn and indigestion. These symptoms can sometimes happen after stopping long-term use of stomach acid-reducing medicines called Proton Pump Inhibitors (PPIs). The study wants to find out if Talcid is effective in managing these rebound symptoms, how quickly it works, and how people feel about using it. Participants will take Talcid as needed for four weeks and record their experiences. Doctors will also share their thoughts on the treatment. The goal is to gather real-world information to support Talcid's use for these specific acid-related issues.

At a glance

Status

Recruiting

Sponsor

Bayer

Enrolment target

167

Start

18 Nov 2025

Estimated completion

31 Oct 2026

Gastroesophageal Reflux

What is this study about?

Imagine you've been taking a medicine called a Proton Pump Inhibitor (PPI) for a while to help with symptoms like heartburn or stomach ulcers. These medicines are really good at reducing stomach acid. However, sometimes when people stop taking PPIs, especially after using them for a long time, their body can temporarily produce too much stomach acid again. This is called 'acid rebound' and can lead to uncomfortable symptoms like heartburn or indigestion coming back.

This study is looking at a medicine called hydrotalcite, which you might know as Talcid. Doctors sometimes recommend Talcid for acid-related symptoms. The aim of this study is to see if Talcid can effectively relieve these uncomfortable 'acid rebound' symptoms after someone has stopped taking their long-term PPI. It also wants to understand how people feel about using Talcid and if it's a good alternative for managing these symptoms.

Researchers want to see if Talcid helps people avoid going back to using PPIs during the study period. They will also look at whether it eases specific symptoms like heartburn, reflux, stomach pain, feeling full, and sickness. Your experiences and satisfaction with Talcid, and your doctor's opinion, will help us understand its real-world benefit.

Key takeaways

The study helps understand how Talcid works for heartburn after stopping old stomach acid medicine.
It's for people who experience 'acid rebound' when they stop long-term PPIs.
You'll use Talcid as needed for four weeks and share your experiences.
Your doctor will also provide feedback on the treatment.
The study aims to gather real-world proof of Talcid's effectiveness.
It could help improve future treatment advice for similar conditions.

Who may be eligible?

This study is looking for adults aged 18 or older.

To join, you must have stopped taking a daily PPI medicine that you used for at least eight weeks, and you no longer need it for a specific medical reason. After stopping the PPI, you should now be experiencing acid-related symptoms, like heartburn, that have come back because of the 'acid rebound' effect.

You cannot join if you have been diagnosed with more severe forms of reflux disease (like GERD LA grade C/D), pregnant or breastfeeding, have serious kidney problems, or are allergic to any ingredients in Talcid.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you stopped taking a daily PPI for at least 8 weeks because you no longer need it?
Are you now experiencing heartburn or indigestion symptoms after stopping your PPI?
Do you NOT have a severe form of reflux disease (GERD LA grade C/D)?
Are you NOT pregnant or breastfeeding, and do NOT have severe kidney issues or an allergy to Talcid ingredients?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you'll use Talcid chewable tablets whenever you feel acid-related symptoms, for a period of four weeks. This means you'll only take it 'as needed' when symptoms appear. You will need to buy Talcid for your own use.

During this time, you'll be asked to fill out questionnaires to record how well Talcid helps your symptoms, how quickly it provides relief, and how generally satisfied you are with the treatment. Your doctor will also share their thoughts on how suitable and effective the treatment is for you. The study is designed to gather information about your normal experience, so there won't be extra doctor visits beyond what you would usually have.

Potential risks and benefits

A potential benefit of joining this study is that Talcid might help relieve your uncomfortable acid rebound symptoms. Your experiences will also contribute to understanding more about this common issue. Potential risks are generally low, as Talcid is a commonly used medication for acid relief. However, like any medicine, you could experience side effects, or it might not work for you. You have the right to withdraw from the study at any time without giving a reason.

Locations (2)

Bayer Vital GmbH
Verified postcode
Leverkusen, Germany· Recruiting
Bayer Germany
Verified postcode
Wuppertal, Germany· Not yet recruiting

Common questions

What is a PPI?

PPIs are medicines like omeprazole or lansoprazole that reduce the amount of acid your stomach makes, often used for heartburn or ulcers.

What is 'acid rebound'?

This is when your stomach temporarily makes more acid than usual after you stop taking long-term PPI medication, causing symptoms like heartburn.

What is hydrotalcite (Talcid)?

Hydrotalcite is an antacid medicine that helps neutralise stomach acid and relieve symptoms like heartburn and indigestion.

How long will I take part?

You will use Talcid as needed for your symptoms over a four-week period and fill out questionnaires about your experience.

Do I have to pay for the Talcid?

Yes, you will need to buy Talcid for your own use if you join the study.

How to find out more

Bayer Clinical Trials Contact

clinical-trials-contact@bayer.com (+)1-888-84 22937 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.