CompletedObservational

Contrast sensitivity evaluation using different glare levels

This research project is investigating how glare from artificial lenses, often used in eye surgery, might affect a person's vision. We want to find the best way to measure this glare accurately. This helps ensure these lenses meet international safety standards and provide clear vision for patients. We'll be using three different eye tests to see how sensitive your eyes are to contrasts (differences between light and dark) under various glare conditions. We're inviting around 50 volunteers aged between 45 and 55 to take part. The study involves two short visits to a clinic to perform these eye tests.

At a glance

Status

Completed

Sponsor

Ocular Technology Group Ltd

Enrolment target

Start

21 Nov 2025

Estimated completion

31 Mar 2026

Glare produced by intraocular lenses

What is this study about?

This study is all about understanding how glare, which can sometimes come from artificial lenses put into the eye (called intraocular lenses), affects your vision. Think of it like looking at car headlights in the dark; sometimes they cause a distracting glare.

Organisations that set standards for medical devices, like the ISO, have rules about how much glare these lenses can produce. This study aims to check different ways of measuring this glare. We want to find the most accurate and reliable methods to measure how much contrast (the difference between light and dark) you might lose because of glare. This is important to make sure that artificial lenses are designed to give patients the best possible vision without too much glare.

Specifically, researchers will use three different types of eye tests to measure how well you see contrasts. These tests will be done under different light conditions, including one with no glare and then three different levels of glare. The goal is to see which testing methods work best to identify and measure glare according to existing safety standards.

Key takeaways

This study helps improve eye lenses for people needing surgery.
It measures how different lenses might cause glare and affect vision.
You'll have two visits for eye tests (contrast sensitivity) under various light conditions.
It's for healthy volunteers aged 45-55 with good vision.
Your participation helps advance eye care for others.
You can stop participating at any time.

Who may be eligible?

To join this study, you need to be between 45 and 55 years old. Your eyesight should be generally good after correction with glasses, meaning you can see clearly.

Your eyes should also be healthy, without any current or past history of serious eye diseases or injuries that affect your vision. This means no conditions like glaucoma, cataracts (unless very mild and not affecting your vision significantly), or issues with your retina.

You cannot take part if you have certain health conditions that affect your eyes, or if you are taking medications that are known to significantly change your vision or eye stability. Also, if you are closely related to or live with the study's researchers or their staff, you won't be able to participate to ensure fairness.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 45 and 55 years old?
Do you have good corrected vision (with glasses) of at least 20/20 in each eye?
Are your eyes healthy, with no history of serious eye diseases or injuries?
Are you NOT currently taking medications that significantly affect eye stability or vision?
Are you NOT a close family member of the research team?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you'll visit the research clinic twice. The first visit is for a screening to confirm you're suitable for the study and to familiarise you with the tests. The second visit will involve the actual eye tests. During this visit, you'll have three different eye tests. For each test, you'll first be tested without any glare, and then with three different levels of glare. The order of these glare tests will be picked randomly. The entire study is expected to run from November 2025 to June 2026, and your involvement would be during this period, across your two visits.

Potential risks and benefits

This study is designed to help understand how to best measure glare from artificial eye lenses, ultimately aiming to improve the quality of future lenses for patients. While there isn't a direct personal health benefit from taking part, your contribution will help improve eye care for many others. The main risk is the slight discomfort or eye strain from undergoing the various eye tests under different light conditions, but these tests are standard eye examinations and are not typically harmful. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Ocular Technology Group International
City only
London, England

Common questions

What is 'contrast sensitivity'?

Contrast sensitivity is how well you can tell the difference between objects and their backgrounds, especially when there isn't much difference in colour or brightness. It's important for seeing in low light or fog.

What are 'intraocular lenses'?

These are artificial lenses that are surgically placed inside the eye, usually to replace your natural lens if it becomes cloudy (a cataract) or to correct vision problems.

Will I have anything put into my eyes?

No, nothing will be put into your eyes. You will only be performing various eye tests where you look at charts or screens.

Who is paying for this study?

The study is being funded by Alcon Research, LLC, a company based in the USA that makes eye care products.

What if I wear contact lenses?

The eligibility criteria mention 'spectacle refraction', so you might need to wear your glasses for the tests. It's best to discuss this with the study contact if you're interested.

How to find out more

Deborah Moore

dmoore@otg.co.uk +44 (0)2072224224 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.