RecruitingNAINTERVENTIONAL

Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia

This study, called HOMI-LUNG - HAP, is part of a larger international project to understand the links between serious lung infections like pneumonia and long-term heart and lung problems. We know that after pneumonia, some people are more likely to develop heart conditions, and this research aims to find out why. We're looking at how your body and the tiny germs living inside you (your microbiome) change after pneumonia, and how these changes might lead to heart or breathing issues. By taking part, you'd help us learn more about how to identify patients at risk and develop better ways to prevent these problems after pneumonia. We're studying people with different health backgrounds, including those who have recently had hospital-acquired pneumonia, and those with existing heart conditions or risk factors.

At a glance

Status

Recruiting

Phase

Sponsor

Nantes University Hospital

Enrolment target

300

Start

02 Jan 2025

Estimated completion

01 Jan 2029

Hospital Acquired Pneumonia (HAP)Cardiovascular and Respiratory Disease

What is this study about?

When you get a serious lung infection like pneumonia, your body works hard to fight it off. But sometimes, even after you recover from the infection itself, pneumonia might have lasting effects on your body, particularly on your heart and lungs. This research project, called HOMI-LUNG - HAP, is designed to understand these long-term changes better.

Think of it like this: your body is a complex system, and sometimes an event like pneumonia can upset the balance. We want to explore how the tiny organisms living inside you (your 'microbiome') change after pneumonia and if these changes are linked to heart and breathing problems later on. The study will help us identify if certain types of pneumonia or certain ways people recover lead to a higher risk of heart or lung issues. This deeper understanding could lead to new ways to support patients after pneumonia and prevent these complications.

The ultimate goal is to improve care for everyone who experiences pneumonia. By participating, you'd be contributing to important knowledge that could help doctors better understand the risks after pneumonia, identify who might need closer monitoring, and develop new treatments or preventive strategies to keep people healthier in the long run.

Key takeaways

This study investigates long-term effects of pneumonia on heart and lung health.
It aims to understand why some people get heart problems after pneumonia.
It involves blood tests, swabs, and heart/lung function checks.
Your participation helps improve future care for patients with pneumonia.
You can withdraw from the study at any time without affecting your care.

Who may be eligible?

This study is looking for both men and women between the ages of 18 and 80. You might be able to take part if you have certain heart conditions, or if you're at risk of them. This includes people who have recently been in hospital for a heart attack or related problem, or those having heart bypass surgery. We're also looking for people with a high risk of heart disease, even if they haven't had it yet, for example, due to high cholesterol in their family.

A key group we're looking for are those who have recently recovered from hospital-acquired pneumonia (pneumonia caught while in hospital) and were on a breathing machine. You also need to have at least one risk factor for heart disease, like being over 65, smoking, having high blood pressure, or diabetes.

However, you can't take part if you're pregnant or breastfeeding, if you have a weakened immune system, or if a doctor believes you have a very low chance of survival in the next month. Also, you won't be able to join if you've had pneumonia within the last year (unless you're in the group specifically for hospital-acquired pneumonia) or if you are under legal guardianship.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 80 years old?
Have you recently recovered from pneumonia caught in hospital and needed a breathing machine?
Do you have a personal or family history of heart problems, or risk factors like high blood pressure or diabetes?
Do you have health insurance?
Are you NOT pregnant or breastfeeding, and do you NOT have a weakened immune system?

Answer every question to see your result.

What does participation involve?

If you decide to join this study, you would undergo a series of tests and provide some samples. These generally include giving blood samples and swabs from your mouth and throat. You would also have heart tests like an ECG (a recording of your heart's electrical activity), and breathing tests such as spirometry and plethysmography to check your lung function. There would also be a special exercise test to see how your heart and lungs work together when you're active. The exact tests and how often they happen will depend on which group you are in and will be clearly explained before you agree to take part. The study aims to look at changes over a longer period, so there will likely be follow-up appointments.

Potential risks and benefits

Taking part in this study could offer some benefits, such as gaining a better understanding of your own heart and lung health through the various tests. You would also be contributing valuable information that could help improve future care for many patients. As with any medical study, there are some potential risks, mainly related to the minor discomforts of blood draws or the physical exertion of exercise tests. All procedures are standard medical practices, and your safety is our top priority. You are free to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (5)

Angers University Hospital
Verified postcode
Angers, France· Not yet recruiting
Nantes University Hospital
Verified postcode
Nantes, France· Recruiting
Rennes University Hospital
Verified postcode
Rennes, France· Not yet recruiting
Rouen University Hospital
Verified postcode
Rouen, France· Not yet recruiting
Toulouse University Hospital
Verified postcode
Toulouse, France· Not yet recruiting

Common questions

What is 'hospital-acquired pneumonia'?

This is a type of lung infection that you get while you are staying in hospital for another health problem.

What does 'microbiome' mean?

Your microbiome refers to the collection of tiny living germs, like bacteria, that naturally live inside and on your body, for example, in your gut and airways.

Will taking part in this study affect my usual medical treatment?

No, participating in this study will not change the standard medical care you receive for any of your conditions.

What happens to my samples after the study?

Your samples will be used for research purposes to better understand the links between pneumonia and other illnesses, always protecting your privacy.

How long will I be involved in the study?

The study aims to look at long-term changes, so your involvement may last for an extended period with follow-up appointments. The exact duration will be explained to you.

How to find out more

Antoine ROQUILLY

antoine.roquilly@univ-nantes.fr +33253482840 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.