RecruitingOBSERVATIONAL

Impact of Human Papillomavirus Carriage on IVF/ICSI Results (HPV AMP)

This study, called HPV AMP, is investigating how the Human Papillomavirus (HPV) might affect women's fertility, specifically when they are undergoing IVF or ICSI treatments. While HPV is common and known to affect male fertility, its role in female infertility is less clear. This research aims to understand if there's a link between having HPV and the outcomes of IVF, such as successful pregnancies. Finding a clear connection could be an important reason for more people to get the HPV vaccine, as it's a preventable virus. The study is welcoming new patients at Brest University Hospital's fertility clinic to participate.

At a glance

Status

Recruiting

Sponsor

University Hospital, Brest

Enrolment target

618

Start

04 Feb 2022

Estimated completion

04 Feb 2026

Human Papilloma Virus Infertility, Female

What is this study about?

This study is called HPV AMP, and it's looking into something very important: how the Human Papillomavirus (HPV) might affect women who are trying to get pregnant using IVF or ICSI. You might know that HPV is a very common virus, and it's already understood to sometimes affect male fertility. However, we don't know as much about its impact on women's ability to get pregnant.

The main idea behind this research is to see if having HPV can change the chances of a successful pregnancy when a woman is going through fertility treatments. If the study finds a strong connection, it could be a very persuasive reason for more people to consider getting the HPV vaccine. This vaccine is already available and can protect against the virus, so understanding its full effects on health, including fertility, is really important for public health.

The researchers will be working with women who are starting fertility treatment at Brest University Hospital. They will look at whether these women have HPV and then compare their treatment results, like how well their ovaries respond to stimulation and if they become pregnant, with those who don't have HPV. This will help them figure out if HPV plays a role in the success of fertility treatments.

Key takeaways

The study explores how HPV might affect IVF success in women.
It aims to understand if HPV impacts the chances of getting pregnant with fertility treatment.
Findings could support the importance of the HPV vaccine for fertility.
Participation involves HPV testing (if needed) and sharing your IVF outcome data.
Your standard fertility treatment will not change by joining the study.
The study is welcoming women aged 25 to 37 years and 11 months undergoing IVF.

Who may be eligible?

This study is looking for women who are between 25 and 37 years and 11 months old. You should have a specific type of hormone level, called AMH, which should be 1.1 ng/ml or higher.

You also need to be starting either your first or second round of IVF treatment. The study is open to women experiencing infertility for various reasons.

However, you cannot take part if you are younger than 25 or 38 years old or older. If your AMH level is below 1.1 ng/ml, or if you are under legal protection, you won't be able to join. Of course, if you simply don't want to participate, that's perfectly fine.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you a woman between 25 and 37 years and 11 months old?
Is your AMH level 1.1 ng/ml or higher?
Are you preparing for your first or second round of IVF treatment?
Are you seeking fertility treatment for any reason?
Are you able to agree to participate without any pressure?

Answer every question to see your result.

What does participation involve?

If you decide to take part, the first step will be to make sure your HPV test is up-to-date. If your last test was more than a year ago, you'll have one done. The study will then follow your journey through your IVF or ICSI treatment, as planned by your doctors. This means they will keep track of how your body responds to the fertility medications and whether you become pregnant. You won't have any extra medications or unusual procedures because of the study. The researchers will simply collect information from your standard treatment. This study is planned to include new patients over a period of three years.

Potential risks and benefits

There are no known direct medical risks from participating in this study, as it primarily involves looking at your existing medical information and standard HPV testing. You won't receive any new treatments or procedures specifically for the study. The potential benefit is that the findings could help us understand more about HPV and female fertility, which might lead to better advice and treatment for women in the future, and potentially encourage more people to get vaccinated against HPV. You always have the right to withdraw from the study at any time without it affecting your medical care.

Locations (1)

CHRU de Brest
Verified postcode
Brest, France· Recruiting

Common questions

What is HPV?

HPV, or Human Papillomavirus, is a common virus that can affect the skin and mucous membranes. Some types can cause certain cancers, like cervical cancer, and it can be spread through sexual contact.

Will taking part in this study change my IVF treatment?

No, your IVF or ICSI treatment will continue exactly as your doctors have planned. This study mainly involves collecting and reviewing information from your standard care.

Do I need to pay for anything if I join the study?

No, you don't need to pay to participate. If your HPV test needs updating, that will be arranged as part of the study if you agree.

How long will my information be used?

The study is planned to collect data from new patients over three years. Your information will be analysed as part of this research to understand the link between HPV and fertility.

If I have HPV, does it mean I can't get pregnant?

Not necessarily. This study is trying to understand if there is a link and what that link might be. Having HPV doesn't automatically mean you can't get pregnant, but the research will help us learn more.

How to find out more

Sarah BOUEE

sarah.bouee@chu-brest.fr 02 98 22 39 70 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.