Delayed Against Rapid Sequence Induction in Adults With Medical Diseases Undergoing Emergency Endotracheal Intubation.
This study aims to find out the best way to help critically ill adults breathe when they need a breathing tube put in urgently (a process called intubation) in intensive care. Researchers are comparing two methods: Delayed Sequence Induction and Rapid Sequence Induction. They want to see if one method causes fewer serious problems, like big changes in blood pressure, during the procedure. The study also explores how best to measure these problems accurately. Participants will receive one of the two intubation methods and will get a phone call 90 days later. All other information will be collected from their regular hospital records, so there won't be any extra tests.
At a glance
What is this study about?
When someone is very ill and can't breathe properly on their own, doctors sometimes need to insert a breathing tube into their windpipe. This procedure is called endotracheal intubation. It's often done in an emergency, and it's very important to do it as safely as possible. This study is looking at two different approaches doctors use to prepare a patient for this procedure, called Delayed Sequence Induction and Rapid Sequence Induction.
Rapid Sequence Induction is a common method, where medicines are given quickly to make the patient sleep and relax their muscles so the breathing tube can be placed. Delayed Sequence Induction involves giving medicines in a slightly different order and timing, which doctors hope might reduce the chance of problems, particularly sudden drops or changes in blood pressure.
The main goal of this research is to see if Delayed Sequence Induction is better than Rapid Sequence Induction at preventing these serious blood pressure changes. It also wants to work out the best and most accurate ways to measure these problems in future studies. This research is important because it could help doctors choose the safest way to help critically ill patients breathe when every second counts.
Key takeaways
- Compares two safe intubation methods for critically ill adults.
- Aims to find the method causing fewer blood pressure problems.
- No new or extra tests specific to the study.
- Data collected from routine hospital care.
- Includes a follow-up phone call at 90 days.
Who may be eligible?
This study is looking for adults aged 18 or older who need an emergency breathing tube inserted within the next hour. The doctor performing the procedure must be experienced in helping critically ill patients breathe in this way.
You would not be able to join if you are having the breathing tube inserted during CPR (cardiopulmonary resuscitation) or immediately after your heart has restarted but you are still very unstable. You also can't take part if a doctor thinks it's too risky for you, or if you have known allergies or reactions to certain medicines (Ketamine, Esketamine, Midazolam, or Rocuronium).
Additionally, if doctors expect it will be very difficult to put in your breathing tube and plan to use a special 'awake' method, you wouldn't be suitable for this study. Pregnant or breastfeeding women are also unable to join.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 or older and need an emergency breathing tube?
- Do you have no known allergies to Ketamine, Esketamine, Midazolam, or Rocuronium?
- Are you NOT pregnant or breastfeeding?
- Is your intubation NOT happening during CPR or when very unstable due to a recent heart restart?
- Are you NOT expected to need a special 'awake' intubation method?
What does participation involve?
If you take part in this study, you will receive emergency endotracheal intubation using either the Delayed Sequence Induction method or the Rapid Sequence Induction method, as decided by the study team. This procedure is part of your urgent medical care. There are no extra tests or appointments specifically for the study beyond what would normally happen during your intensive care stay. About 90 days after your breathing tube was put in, you will receive a phone call to check on how you are doing. All other information needed for the study will be gathered from your routine hospital records, so there won't be any additional procedures or assessments.
Potential risks and benefits
Locations (1)
- Interdisciplinary Medical ICU, Leipzig Medical University CenterVerified postcodeLeipzig, Germany· Recruiting
Common questions
What is intubation?
Intubation means placing a breathing tube into your windpipe to help you breathe, usually with the help of a machine, when you are very ill and can't breathe on your own.
What is 'Delayed Sequence Induction' and 'Rapid Sequence Induction'?
These are two different ways doctors give medicines to make you sleep and relax your muscles before putting in a breathing tube. They differ in the timing and order of the medicines.
Will I have extra tests if I join the study?
No, you won't have any extra tests. All information, apart from a follow-up phone call, will be collected from your existing hospital records during your intensive care stay.
What are 'hemodynamic complications'?
This refers to problems with your blood pressure or heart rate, such as sudden drops in blood pressure, that can sometimes happen during intubation.
How long will I be in the study?
Your direct participation involves the intubation procedure itself. The follow-up is a single phone call 90 days later. No other active participation is required from you.
How to find out more
Anton J Pelka
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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