RecruitingOBSERVATIONAL

Predictors of Risk in Left Ventricular Non-Compaction

This study aims to understand more about a heart condition called Left Ventricular Non-Compaction (LVNC). This condition means the heart muscle hasn't developed quite as smoothly as it should. The researchers want to find out why some people with LVNC develop more serious heart issues, like abnormal heart rhythms or heart failure. They'll be looking to see if certain genes play a role, or if other signs, like how the heart muscle stretches, can predict problems. The study will involve looking at existing medical records of people with LVNC over ten years to track how the condition progresses and what factors might influence it.

At a glance

Status

Recruiting

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Enrolment target

500

Start

01 Sep 2023

Estimated completion

01 Aug 2033

Left Ventricular Noncompaction

What is this study about?

Imagine your heart as a very strong pump. The left side, called the left ventricle, is especially important for sending oxygen-rich blood all around your body. In a condition called Left Ventricular Non-Compaction (LVNC), this part of the heart muscle isn't as smooth and firm as it should be. Instead, it can be a bit more spongy, with little pockets, which can make it harder for the heart to pump blood effectively. This condition can be present from birth, and while some people might not have many problems, others can face serious heart issues later on.

Doctors know that LVNC can sometimes lead to complications like sudden, serious heart rhythm problems. However, they don't fully understand why some people are more at risk than others. This study aims to fill those gaps in knowledge. The researchers want to find out if certain genetic factors make a difference, or if other measurements, like how the heart muscle stretches (called 'strain'), can help predict who might be at higher risk for complications.

Ultimately, this research is about helping people with LVNC live healthier lives. By understanding more about this condition and what makes it worse, doctors hope to get better at diagnosing it earlier, predicting who might need more careful monitoring, and finding the best ways to manage and treat it. This could lead to better care and fewer serious problems for those living with LVNC.

Key takeaways

This study investigates a heart condition called Left Ventricular Non-Compaction (LVNC).
It aims to identify factors that put people with LVNC at risk for serious heart problems.
Researchers will review existing medical records over ten years, so no new appointments are needed.
The goal is to improve understanding, diagnosis, and treatment for LVNC patients.
Participants must be 18+ and have a confirmed LVNC diagnosis.

Who may be eligible?

To be included in this study, you must have a confirmed diagnosis of Left Ventricular Non-Compaction (LVNC). You also need to be 18 years old or older.

On the other hand, you can't be part of this study if you don't meet these requirements. Also, if you have another type of heart muscle disease (cardiomyopathy) that isn't LVNC but is linked to a genetic problem, then you wouldn't be able to take part.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

I have been diagnosed with Left Ventricular Non-Compaction (LVNC).
I am 18 years old or older.
I do not have any other heart muscle conditions (cardiomyopathy) linked to a genetic problem, besides LVNC.
My medical records are available for review by the research team.

Answer every question to see your result.

What does participation involve?

If you are eligible for this study, you will not have to do anything extra. The study involves looking at your existing medical records over ten years. This might include information already gathered by doctors or information that will be collected during your regular check-ups at the Inherited Arrhythmia Clinic.

Potential risks and benefits

There are no direct risks to participants in this study, as it only involves reviewing existing medical records and does not require any new tests or treatments. The potential benefit is that the information gathered from your medical records, alongside many others, will help doctors learn more about Left Ventricular Non-Compaction, which could lead to better diagnosis and treatment for people with this condition in the future. You have the right to withdraw your medical information from the study at any time.

Locations (1)

London Health Sciences Centre - University Hospital
Verified postcode
London, Canada· Recruiting

Common questions

What is Left Ventricular Non-Compaction (LVNC)?

LVNC is a heart condition where the muscle of the left side of the heart (the main pumping chamber) is not as smooth and firm as it should be. It can look spongy, which might make it harder for the heart to pump blood efficiently.

Why is this study being done?

Doctors want to better understand why some people with LVNC develop serious heart problems, like abnormal heart rhythms. They hope to find out what factors, including genetics, predict who might be at higher risk.

Do I need to do anything if I'm in this study?

No, you don't need to do anything extra. The study will only look at information that is already in your medical records, or information gathered during your regular doctor's appointments.

Will my personal information be kept private?

Yes, your medical data will be stored securely within a large clinical registry at the London Health Sciences Centre, and researchers will ensure your privacy is protected.

Who is eligible to take part?

You need to have a confirmed diagnosis of LVNC and be 18 years old or older.

How to find out more

Dr. Habib Khan

habib.khan@lhsc.on.ca 519-663-3746 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.