Not yet recruitingOBSERVATIONAL

Cognition and Patients With Lung Cancer

This study explores thinking and memory problems, sometimes called 'chemofog', in people diagnosed with operable non-small cell lung cancer. These problems can affect daily life and quality of life. The study wants to find out when these difficulties appear during treatment, which specific mental abilities (like memory or attention) are most affected, and how much they bother patients. Researchers will also look at other factors like mood, tiredness, and social background, as these might influence how much 'chemofog' someone experiences. Understanding these issues better will help doctors and nurses offer more support and improve the lives of people with lung cancer.

At a glance

Status

Not yet recruiting

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrolment target

Start

01 Jan 2026

Estimated completion

01 Jan 2029

Localized, Operable Non-small Cell Lung Cancer

What is this study about?

When people are treated for cancer, some find they have difficulties with their thinking and memory. This is sometimes called 'chemofog' or 'cancer-related cognitive impairment'. It can involve things like forgetting names, struggling to focus, or taking longer to process information. While usually mild, these issues can make everyday tasks harder, affect returning to work, and generally impact quality of life.

This study focuses specifically on people in the UK who have been diagnosed with localized non-small cell lung cancer that can be treated with surgery. The main aim is to understand better when these memory and thinking problems start during treatment, what specific brain functions are affected (like memory, attention, or concentration), and how much they bother the patient. We also want to see if other things, like your mood, how tired you feel, or your social situation, affect these problems.

By gathering this information over time, researchers hope to get a clearer picture of 'chemofog' in lung cancer patients. This understanding is crucial because it can help medical teams offer better support and advice to patients, making a real difference to their well-being during and after cancer treatment.

Key takeaways

Exploring why some lung cancer patients experience 'chemofog' (memory/thinking problems).
Focuses on people with localized, operable non-small cell lung cancer.
Participation involves completing online questionnaires and thinking tests from home.
Aims to understand when these problems start and what affects them.
Hopes to improve support and quality of life for future patients.

Who may be eligible?

This study is looking for adults aged between 18 and 74 who have been diagnosed with a specific type of lung cancer called localized non-small cell lung cancer, which is suitable for surgical treatment. You would need to be comfortable using a computer, tablet, or phone to fill out online questionnaires from your home.

Some things would mean you couldn't take part. For example, if you already have a known memory or thinking problem, or if you have certain existing medical conditions like Parkinson's disease, dementia, or a history of a stroke. If you've had cancer treatment within the last 10 years, or have certain current health problems that could affect your thinking, you also wouldn't be able to join. Lastly, the study materials are in French, so you would need to be able to read and understand French to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 74 years old?
Do you have localized, operable non-small cell lung cancer?
Can you read and understand French?
Do you have access to a phone, tablet, or computer with internet at home?
Do you NOT have a pre-existing memory or thinking problem?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would primarily be asked to complete a series of online questionnaires and cognitive tests from your home. These are designed to check your memory, attention, and other thinking skills, and to understand how you feel. You would need access to a phone, tablet, or computer and the internet to complete these tasks on a platform called Cleanweb. The study aims to follow you over time to see how your thinking and memory might change during and after your lung cancer treatment.

Potential risks and benefits

Taking part in this study may offer the benefit of a deeper understanding of your own cognitive health during treatment, and it contributes to valuable research that could help future lung cancer patients. There are no direct medical risks involved, as the study only involves questionnaires and cognitive tests. The main inconvenience would be the time required to complete the assessments. You are free to withdraw from the study at any time without giving a reason, and this will not affect your medical care.

Locations (1)

Hôpital Cochin - Service de pneumologie
Verified postcode
Paris, France

Common questions

What does 'chemofog' mean?

'Chemofog' is a common term for memory and thinking problems that some people experience during or after cancer treatment.

Will I have to take any new medicines in this study?

No, this study only involves completing questionnaires and cognitive tests; no new medicines are given.

How long will I be involved in the study?

The study aims to monitor your memory and thinking skills over time, so you would be involved for a period during and after your treatment, with details provided by the research team.

Do I need to go to a clinic for appointments?

No, you will complete the questionnaires and cognitive tests from home using your own computer, tablet, or phone.

What kind of lung cancer is this study for?

This study is for people with localized, operable non-small cell lung cancer.

How to find out more

Isabelle HARDY LEGER

isabelle.leger@aphp.fr 01 58 41 24 01 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.