A Study To Assess the Safety, Tolerability, and Efficacy of Imzokitug in Combination With Pumitamig and Platinum-Doublet Chemotherapy (PDCT) Versus Pumitamig and PDCT as First-line Treatment for Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

To be considered for this study, you would need to have non-small cell lung cancer that has been confirmed by a biopsy. It needs to be at an advanced stage (stage 4) or have come back after previous treatment and can't be removed by surgery. This would be your first medicine treatment for your advanced or widespread cancer. We would also need a tissue sample of your cancer from the last five months.

You would generally need to be fairly well and able to carry out daily activities with little difficulty. Your cancer must also be measurable, meaning doctors can see and track its size. We cannot include you if your cancer has certain specific genetic changes that can be treated with other approved medicines, if you've already had immunotherapy, or if you have untreated cancer spread to your brain.

There are a few other health factors that might mean you can't join the study, but the study team would go through all these details with you. Generally, participants need to be 18 years old or older, and the study is open to both men and women.

If you join this study, you will receive either a combination of two new drugs (Imzokitug and Pumitamig) plus chemotherapy, or one new drug (Pumitamig) plus chemotherapy. You won't get to choose which group you are in, as this is decided randomly, like flipping a coin. You will have regular visits to the hospital or clinic to receive your treatments and have various tests done, such as blood tests, scans (like CT scans), and physical exams. These tests help the doctors monitor your health, check how your body is reacting to the treatment, and see if the cancer is responding.

The specific number of visits and tests will depend on the treatment schedule and how you respond. You will be closely monitored for any side effects. Treatment will continue for as long as it is helping you and you are tolerating it well. After completing treatment, you will have follow-up appointments to track your long-term health. The total duration of your involvement could range from several months to a few years, depending on your treatment response and the follow-up plan.