RecruitingObservational

Low Grade Glioma in Children (LOGGIC) Core BioClinical Data Bank

Low-grade gliomas are the most common brain tumours in children and young people. While they grow slowly, finding the best treatment can be challenging. The LOGGIC Core study aims to understand how small changes in a tumour's genetic code affect how it grows and responds to treatment. Doctors are collecting health details along with blood and tumour tissue samples from patients aged 0 to 21 across participating hospitals. Scientists will analyse the DNA to look for patterns. This information will help doctors choose better, more targeted treatments tailored to each person's specific tumour in the future. Taking part will not change your normal medical care. Samples are usually taken during routine operations or tests, meaning there is very little extra risk. The goal is to build a valuable resource that helps improve care for future children and young people facing a brain tumour diagnosis.

At a glance

Status

Recruiting

Sponsor

University of Birmingham

Enrolment target

500

Start

01 Oct 2026

Estimated completion

30 Sep 2031

Low-grade glioma

What is this study about?

A low-grade glioma is a slow-growing type of brain tumour that affects children and young adults. Even though these tumours are not fast-growing, they can still cause health problems and need careful treatment. At the moment, doctors treat many low-grade gliomas in a similar way, but tumours do not always respond the same way in every person. Researchers believe that the secret to better care lies within the tumour's genes.

The LOGGIC Core project is creating a large, secure bank of health information and biological samples from young people with these tumours. When doctors remove a tumour or take a small sample during regular care, leftover tissue and a small blood sample can be sent to researchers. Scientists will study the DNA inside these samples to find out what makes each tumour grow or stop growing.

By matching genetic clues with how patients get on over time, doctors hope to discover biological 'markers'. In the future, these tests could tell doctors right away which treatment is most likely to work best for an individual child. This could spare young patients from treatments that might not help them and lead to gentler, more effective care designed specifically for their tumour type.

Key takeaways

LOGGIC Core is a research study building a DNA databank to better understand low-grade gliomas.
Open to children and young people aged 0 to 21 years.
Uses blood and leftover tumour tissue collected during your routine hospital care.
Does not require any experimental drugs or extra hospital appointments.
Helps scientists develop personalised, kinder treatments for future patients.

Who may be eligible?

This study is open to children, teenagers, and young adults up to 21 years of age who have been diagnosed with a low-grade glioma or a similar slow-growing brain tumour. It includes patients who have just been diagnosed for the first time, as well as those whose tumour has returned or started growing again.

To take part, there usually needs to be tumour tissue available from a past surgery or biopsy, alongside a blood sample. In rare cases where a brain biopsy was considered too risky, a diagnosis made through MRI scans may be accepted for newly diagnosed patients. Patients must also live in a country taking part in the LOGGIC project.

Anyone who is 21 or older, or whose tumour is not classified as a low-grade glioma, will not be able to join this specific study. A doctor will always check all medical details to confirm whether joining is safe and suitable.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

I (or my child) am between 0 and 21 years old.
I have been diagnosed with a low-grade glioma or glioneuronal brain tumour.
I have had, or am having, routine surgery or tests where tissue or blood is collected.
I live in the UK or another participating country.
I am happy to give written consent for my samples and health details to be stored for research.

Answer every question to see your result.

What does participation involve?

Taking part in this study is designed to fit around your regular hospital care. You will not need to take any new medications, switch treatments, or make extra hospital visits purely for the study.

Whenever you have routine surgery, a biopsy, or standard blood tests, the hospital team will collect extra tissue and blood samples with your permission. These samples are sent to research laboratories where scientists study their genetic material. Information about your health and how your treatment is going will also be recorded in a secure database.

The research project is scheduled to run over several years, from late 2026 until 2031. Your samples and health data may be studied during this time to help researchers answer vital questions about low-grade gliomas. You do not need to do anything extra at home once you have agreed to take part.

Potential risks and benefits

Because the samples are taken during your normal hospital procedures, such as a planned operation or a routine blood draw, taking part carries very little extra physical risk. Taking part will probably not help you directly, but it offers a meaningful way to help other children and young people diagnosed with brain tumours in the future. You are completely free to decide whether to take part. If you say no, or if you decide to withdraw your consent at any point, your normal NHS care and treatment will continue unaffected.

Locations (16)

Alder Hey Children's Hospital
Approximate
Liverpool, England
Birmingham Childrens Hospital
Approximate
Birmingham, England
Bristol Royal Hospital for Children
Approximate
Bristol, England
The Christie
Approximate
Manchester, England
Royal Victoria Infirmary
Approximate
Newcastle upon Tyne, England
Great Ormond Street Hospital for Children
Unverified
London, England
John Radcliffe Hospital
Unverified
Oxford, England
Leeds General Infimary
Unverified
Leeds, England
Noahs Ark Childrens Hospital for Wales
Unverified
Cardiff, Wales
Queens Medical Centre
Unverified
Nottingham, England
The Royal Belfast Hospital for Sick Children
Unverified
Belfast, Northern Ireland
Royal Hospital for Children and Young People
Unverified
Lothian, Scotland

Common questions

Will taking part change my current cancer treatment?

No. This is an observational study, which means it only collects samples and information. Your doctor will continue to give you the standard, best possible treatment for your tumour.

Do I have to go through extra surgery to take part?

No. Researchers will only use small pieces of tissue taken during a surgery or biopsy that you were already having as part of your normal care.

Will having blood taken hurt?

Having blood taken can cause brief discomfort or slight bruising. Wherever possible, the team will collect the research blood sample at the same time as your routine blood tests to avoid extra needles.

Will my personal data be kept safe?

Yes. All samples and medical details are stored securely without your direct identifying details, following strict legal and medical privacy rules.

Can I leave the study if I change my mind?

Yes, you or your parent or guardian can withdraw at any time without giving a reason, and it will not affect the quality of your medical care.

How to find out more

Study Team

LOGGICCore@trials.bham.ac.uk - Official trial record

Always speak to your GP or specialist before deciding to take part in a study.