RecruitingOBSERVATIONAL

Ketamine Enhances Analgesia and Mood in Chronic Pain Patients

Living with long-term (chronic) pain often comes with mood difficulties like anxiety or depression. This research is exploring whether Ketamine injections, which are used to help manage pain, could also improve these mood issues for people. The study involves looking at information from adults who are already receiving Ketamine injections for their pain. Before and after these injections, doctors collect information about their pain levels, how well they're sleeping, and any anxiety or depression they might be feeling. The aim is to see if reducing pain with Ketamine could lead to meaningful improvements in their overall well-being, including their mood and sleep. It's a way for doctors to learn more about the link between pain relief and mental health.

At a glance

Status

Recruiting

Sponsor

Salem Anaesthesia Pain Clinic

Enrolment target

500

Start

02 Feb 2018

Estimated completion

31 Dec 2025

Mood Disorder; Opioid Mood Insomnia

What is this study about?

Many people who live with ongoing pain also find they struggle with their mood, experiencing feelings like anxiety or depression. This study is exploring a connection between pain relief and these emotional difficulties. Doctors are looking at whether a treatment called Ketamine, which is used to help manage long-term pain, might also help to improve a person's mood, how well they sleep, and their levels of anxiety.

The researchers are observing adult patients (aged 20 to 99) who are already receiving Ketamine injections as part of their regular pain management. Before these injections, and again afterwards, information is carefully collected. This includes details about their pain levels, their sleep quality, and how they are feeling emotionally. They use special questionnaires and scales to measure changes in these areas. For example, a small but important change in pain is considered to be a 2-point difference on a pain scale, and similar small changes are being looked at for sleep, anxiety, and depression.

By comparing the information gathered before and after the Ketamine injections, the study hopes to understand if better pain control leads to better mood and sleep. It's an important step in learning how to support people living with chronic pain more holistically, addressing both their physical discomfort and their emotional well-being.

Key takeaways

This study evaluates how Ketamine injections for chronic pain affect mood and sleep.
It involves adults aged 20-99 who already receive Ketamine for pain.
Researchers collect routine information on pain, sleep, anxiety, and depression.
The study aims to understand the link between pain relief and mental well-being.
No new treatments or procedures are involved; it reviews existing patient data.

Who may be eligible?

This study is looking for adults who have long-term pain and also experience mood problems. To be considered, you should already be receiving regular Ketamine injections as part of your pain treatment and follow your treatment plan well. You also need to agree to your health records being reviewed for the study.

There are certain reasons why someone might not be able to join the study. For example, if you have a severe memory or thinking problem, or if you can't understand and agree to take part. Also, if you have a major mental health condition that isn't mood-related, or if you use substances like cannabis, stimulants, or have a substance abuse issue, you wouldn't be able to participate.

Finally, if you don't receive Ketamine injections for your pain, or you don’t usually follow your treatment plan, you wouldn't be suitable for this particular study. The aim is to study people who are already on this specific treatment path.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you an adult with long-term chronic pain?
Do you also experience mood difficulties?
Are you currently receiving regular Ketamine injections for your pain?
Do you follow your medical treatment plan well?
Would you agree to doctors reviewing your health records for the study?

Answer every question to see your result.

What does participation involve?

If you were to take part in this study, it would involve reviewing information that is already collected as part of your regular medical care. You wouldn't be asked to do anything extra beyond your standard treatment with Ketamine injections for your chronic pain. Before and after your Ketamine injections, the medical team would simply be using standard questionnaires and scales, which you might already be familiar with, to record information about your pain, sleep, anxiety, and depression. This data collection would happen as part of your routine appointments for your pain management. There are no additional visits, specific medications to take for the study, or special follow-up appointments required beyond what you already have planned with your pain team.

Potential risks and benefits

Taking part in this study involves no additional risks beyond those associated with your ongoing Ketamine treatment, as it primarily involves reviewing existing medical information. The main potential benefit is contributing to a better understanding of how pain treatment might also help with mood and sleep for people with long-term pain, which could help future patients. You have the right to withdraw your consent for your data to be used in the study at any time, without affecting your medical care.

Locations (1)

Salem Anaesthesia Pain Clinic
Verified postcode
Surrey, Canada· Recruiting

Common questions

What is Ketamine?

Ketamine is a medicine that doctors sometimes use to help manage long-term pain. It works in a different way to some other painkillers.

Will I have to take new medicines?

No, this study only looks at information from people who are already receiving Ketamine injections as part of their usual pain treatment. You won't be given any new medicines for the study.

How will my information be used?

The information collected about your pain, mood, and sleep will be put together with information from other patients to see if there are overall improvements linked to Ketamine. Your personal details will be kept private.

Will taking part change my pain treatment?

No, your pain treatment will continue as normal. This study is just observing the effects of the treatment you are already receiving.

What if I don't want my information used?

You are free to decide not to have your health information included in the study, and this decision will not affect your medical care in any way.

How to find out more

Olumuyiwa Bamgbade, MD,FRCPC

salem.painclinic@gmail.com 17786286600 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.