A Prospective, Multicenter, Single-arm MAC-PD Cohort: a NTM-NET and ESGMYC Collaborative Study

To join this study, you need to be an adult (18 years or older) and have recently been diagnosed with MAC-PD, or have had it before and it has come back. Your doctor must have decided that you need to start the standard three-drug antibiotic treatment for this condition. You also need to fully understand the study and agree to take part by signing a consent form.

There are several reasons why someone might not be able to join. For example, if you are very unwell, have certain other serious health conditions like HIV or cystic fibrosis, or have other active infections like tuberculosis. If you've been on antibiotics for your current MAC infection for more than a month already, or if your previous MAC-PD treatment was less than six months ago, you won't be able to join.

Also, if you have a serious medical condition such as certain cancers that require treatment, or if you have known issues with drug or alcohol use that your doctor believes would make it unsafe for you to participate, you would not be eligible for this study.

This study will mainly involve doctors collecting information about your MAC-PD treatment and progress during your regular doctor visits over the first six months. You won't be given any new or experimental drugs as part of this study; you'll be receiving the standard three-drug antimycobacterial therapy recommended by treatment guidelines. The researchers will simply observe how this treatment works for you.

Researchers will record details about the medicines you take, how well you stick to your treatment plan, and any adjustments your doctor makes to your medication. They will also note any side effects you experience and how your infection responds to the treatment. This information will be gathered during your routine appointments, so there won't be any extra visits specifically for the study. The total duration of active observation for each patient in the study will be six months.