A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer

This study is looking for adults aged 18 and over who have cancer and are about to start certain types of chemotherapy for the first time. Specifically, your chemotherapy should be either AC (Adriamycin and Cyclophosphamide) or a cisplatin-based type, given as a single dose on the first day of each cycle.

There are some reasons why you might not be able to join. For example, if you have certain existing health conditions such as untreated problems with your brain (like some tumours), uncontrolled diabetes, or specific heart conditions. Also, if you already have sickness or vomiting from another cause, or if you're taking medicines that might affect sickness, you might not be suitable.

It's important that you haven't been in another medical study recently and aren't pregnant or breastfeeding, or planning to become pregnant during the study period. Your doctor will carefully check all these points to see if this study is right for you.

If you join this study, you will be in it for about two months. During this time, you'll receive either the new medicine, a dummy medicine (placebo), or standard anti-sickness treatments, along with your regular chemotherapy. You'll have regular check-ups and assessments to see how you're feeling, whether the medicine is working, and to monitor for any side effects. These assessments might include blood tests and discussions about your symptoms. The doctors and nurses will explain everything in detail, and you'll have ongoing support throughout your time in the study.