MSOT as Non-invasive Biomarker for Diagnosis and Monitoring of Neuromuscular Diseases
This study is investigating a new, gentle scanning method, called Multispectral Optoacoustic Tomography (MSOT), to help diagnose and monitor muscle diseases in children. Researchers want to see if MSOT can effectively measure different substances like oxygen, fats, and muscle-related proteins in the muscles without needing invasive procedures. This could provide a clearer picture of how muscle diseases affect the body over time. The study will compare these new scan results with information already gathered through standard medical checks. The goal is to discover if MSOT can become a useful tool for doctors to better understand these conditions and improve care for children with neuromuscular diseases. No extra tests are involved beyond the MSOT scans.
At a glance
What is this study about?
This study is exploring a new way to understand muscle diseases in children, using a special type of scan called Multispectral Optoacoustic Tomography, or MSOT. Imagine an ultrasound, but even more detailed. It's a gentle method that doesn't use X-rays or require any needles or surgery. The main aim is to see if these MSOT scans can help doctors diagnose muscle conditions and closely track how they change over time in young patients.
When children have neuromuscular diseases, their muscles often show changes in things like how much oxygen they get, the types of fats present, or certain proteins. The MSOT scan aims to measure these specific things without causing any discomfort. Researchers will compare these new scan results with information from routine hospital visits and tests to see if MSOT can offer valuable new insights.
Ultimately, the hope is that this study will show if MSOT can become a helpful, non-invasive tool for doctors. This could mean better ways to understand and manage neuromuscular diseases, potentially leading to improved care and more tailored treatments for children in the future.
Key takeaways
- This study uses a new, gentle scan called MSOT.
- It aims to better diagnose and track muscle diseases in children.
- No needles, surgery, or new medicines are involved.
- Results could lead to better understanding and care for these conditions.
- The study lasts about 3 years, with repeated scans over time.
Who may be eligible?
This study is looking for children with a confirmed or suspected neuromuscular disease. That means doctors either know for sure or strongly believe they have a condition affecting their muscles and nerves. These children can range from newborn babies (who were born at full term) up to 18 years old. A parent or legal guardian would need to give permission for them to take part.
However, some children might not be able to join. For example, if their diagnosis isn't a muscle or nerve condition, or if they have any active skin problems (like infections or injuries) where the scan would take place. Children who are very unwell, have tattoos on the scan area, or take medicines that make their skin very sensitive to light would also not be able to participate. The doctor overseeing the study also needs to ensure it's safe for every child to take part.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Is my child aged between birth (if full-term) and 18 years old?
- Does my child have a confirmed or suspected neuromuscular disease?
- Does my child have healthy skin in the area to be scanned (no active infections, cuts, or tattoos)?
- Is my child otherwise stable and not seriously unwell?
- Is my child not taking medication that makes their skin very sensitive to light?
What does participation involve?
If your child takes part, they will have special scans using a device called Multispectral Optoacoustic Tomography (MSOT). This scan is gentle and doesn't involve needles or surgery. It will be done on a muscle area. The researchers will also look at medical information already collected during your child's routine hospital visits and tests. There will be no extra tests, medications, or procedures beyond the MSOT scan itself. Your child will likely have these scans more than once to see how their condition changes over time. The entire study is expected to last about 3 years, with repeated measurements throughout this period until your child turns 18.
Potential risks and benefits
Locations (1)
- CHEOVerified postcodeOttawa, Canada· Recruiting
Common questions
What is a neuromuscular disease?
These are conditions that affect the muscles and the nerves that control them, leading to weakness or problems with movement.
What is MSOT?
MSOT is a special type of scan that uses light and sound waves to create detailed images of what’s inside the muscles, without needing needles or surgery.
Will my child need any new medicines for this study?
No, your child will not be given any new medicines as part of this study. It only involves the MSOT scans.
How long will my child be in the study?
The study aims to follow children over approximately 3 years, with several MSOT scans during that time to see how the disease changes.
Are there any needles involved?
No, the MSOT scan is completely non-invasive, meaning it doesn't involve any needles, injections, or cutting the skin.
How to find out more
Hanns Lochmuller, Dr.
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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