RecruitingNAINTERVENTIONAL

Effectiveness of the Journey Total Knee Arthroplasty Versus Two Standard of Care Total Knee Arthroplasty Prostheses

This study is looking at different types of knee replacements for people with painful knee arthritis. It compares a newer implant called Journey II with two widely used ones, Stryker and Zimmer. The main goal is to find out if the Journey II knee replacement helps people have better knee movement, walk more naturally, and experience less pain after their surgery. By carefully measuring how knees move and function, researchers hope to understand which implant might offer the best results for patients. The information gathered could also help develop better rehabilitation plans in the future, aiming to improve patients' quality of life after a knee replacement.

At a glance

Status

Recruiting

Phase

Sponsor

University of Alberta

Enrolment target

Start

09 Sep 2019

Estimated completion

01 Dec 2027

Osteoarthritis, Knee

What is this study about?

If you have severe knee arthritis, you might be considering a total knee replacement. This operation, often called TKA, helps many people get rid of pain and move around more easily. It's a very common and successful surgery in the UK.

This particular study wants to understand if one type of knee replacement, the Journey II (made by Smith and Nephew), works differently or better than two other common types, Stryker and Zimmer. Most standard knee replacements are designed to be quite firm and don't allow much natural movement within the joint itself. However, the Journey II is built a bit differently, aiming to copy how your knee naturally moves, a bit like the cushioning pads (meniscus) in your original knee. The researchers think this might help people feel better and move their knees more naturally after surgery.

To find this out, the study will carefully look at important things like how much pain people have, how well they can move their knee, how they walk, and how much force their knee can handle after the operation. By comparing these different knee implants, the study hopes to give useful information that could help doctors decide which knee replacement is best for different patients. This could also lead to better recovery plans after surgery, helping people get back to their daily lives with improved comfort and movement.

Key takeaways

Compares a newer knee replacement (Journey II) with two standard ones (Stryker, Zimmer).
Aims to see if Journey II leads to better knee movement, walking, and less pain.
Suitable for people aged 50-75 having their first knee replacement for arthritis.
Involves extra assessments of knee movement and function before and after surgery.
Results could help improve future knee replacement choices and rehabilitation plans.

Who may be eligible?

To join this study, you would generally need to be between 50 and 75 years old and be having your first total knee replacement for non-inflammatory arthritis. You must be able and willing to attend follow-up appointments and physical therapy sessions after your surgery.

There are also some reasons why you might not be able to join. For example, if you are very overweight (with a BMI of 40 or higher), or if your knee has a very severe bend, bow, or a limited range of motion. You also can't have any active infections in or around your knee.

Other reasons include having had recent leg surgery, needing knee replacements in both knees at the same time, or if you've already had a knee replacement revised. If you have significant other medical conditions that might make it hard to check how the knee replacement is working, or if you're allergic to materials used in the implant, you also wouldn't be able to take part.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 50 and 75 years old?
Are you having a total knee replacement for arthritis?
Is this your first knee replacement on this knee?
Can you attend follow-up appointments and physical therapy?
Are you able to walk and participate in basic assessments?
Do you have a healthy weight (BMI under 40)?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you would receive one of the three knee replacement implants as part of your surgery. Researchers would then assess your knee's movement, how you walk, and your pain levels before your operation and at specific times afterwards, including one year after your surgery. These assessments would involve using special equipment to measure your knee's actions and forces. You would also have regular check-ups and x-rays as part of your standard care, and would follow your usual physical therapy programme. The total duration of your participation in the study assessments would likely be around a year after your surgery.

Potential risks and benefits

A potential benefit of taking part is that you would receive a total knee replacement that could improve your pain and mobility, as is the goal of all such surgeries. You would also be contributing to important research that could help future patients. As with any surgery, there are risks involved with total knee replacement, such as infection, blood clots, or problems with the implant itself. Your doctors will discuss all these standard surgical risks with you. You are free to withdraw from the study at any time without affecting your medical care.

Locations (1)

Edmonton Bone and Joint Centre
Verified postcode
Edmonton, Canada· Recruiting

Common questions

What is osteoarthritis?

Osteoarthritis is a common type of arthritis where the protective cartilage on the ends of your bones wears down over time, causing pain, swelling, and stiffness in your joints, often the knee.

What is a total knee replacement (TKA)?

A total knee replacement is an operation where damaged parts of your knee joint are removed and replaced with artificial parts, typically made of metal and plastic, to help reduce pain and improve movement.

What do 'knee movements and forces' mean?

This refers to how your knee bends, straightens, and rotates, and the different pressures it experiences when you walk, stand, or do other activities. The study will measure these carefully.

Will I get to choose which knee implant I receive?

The study aims to compare the different implants, so you would be assigned one of the three types. Your medical team will explain this process fully.

Will this study affect my standard care?

No, you will still receive the same high standard of care and rehabilitation that all patients undergoing knee replacement receive. The study involves extra measurements and check-ups on top of your usual care.

How to find out more

Ailar Ramadi, PhD

ailar.ramadi@albertahealthservices.ca 780-492-6713 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.