Clinical trial to evaluate Reducose® mulberry leaf extract as a functional food ingredient to improve metabolic health
When we eat carbohydrates, our blood sugar levels rise. Over time, high blood sugar spikes can affect our energy, weight, and general health. Researchers at Oxford Brookes University are running a study to see if a natural plant extract from mulberry leaves, called Reducose®, can slow down sugar absorption in the gut. This study lasts 12 weeks and is looking for healthy, overweight adults aged 18 to 60. Participants will be randomly chosen to take either the real Reducose® supplement or a dummy pill (placebo) with meals. Taking part involves visiting the Oxford clinic three times for routine health checks, wearing a small glucose sensor on your skin, and collecting stool samples at home to check gut bacteria. Participants receive Amazon vouchers as a thank you, along with detailed personal feedback about their body composition and blood pressure.
At a glance
What is this study about?
Every time we eat bread, pasta, rice, or sugary treats, our bodies break these carbohydrates down into glucose. This causes blood sugar levels to rise, triggering the release of insulin. For people who carry extra weight, keeping blood sugar levels steady can become harder over time, which may increase the risk of developing conditions such as type 2 diabetes.
Reducose® is a food supplement derived from white mulberry leaves. Early lab research suggests that it may gently block some of the enzymes in the digestive tract that break down complex sugars. By slowing this process, it might prevent sharp rises in blood sugar after eating and help people feel fuller for longer. Unabsorbed carbs may also reach the bowel to nourish healthy gut bacteria.
This trial aims to find out whether taking Reducose® daily for 12 weeks makes a measurable difference to blood sugar control, body fat, appetite, and gut health. Because it is a food-grade ingredient, scientists want to see if it could be an easy, everyday tool to help people protect their long-term metabolic health.
Key takeaways
- Tests whether a natural mulberry leaf supplement helps control blood sugar and gut health.
- Designed for healthy, overweight adults aged 18 to 60 with a BMI between 25 and 29.9.
- Lasts 12 weeks and involves taking daily capsules (either the supplement or a placebo).
- Requires three visits to Oxford Brookes University, simple blood tests, and wearing a blood sugar sensor.
- Volunteers receive Amazon vouchers and personalised health measurements.
Who may be eligible?
This trial is open to adults aged between 18 and 60 who are generally healthy but classified as overweight. This means having a Body Mass Index (BMI) between 25 and 29.9, along with a body fat level of at least 20% for men or 30% for women.
You cannot take part if you have diagnosed diabetes, an HbA1c (long-term blood sugar marker) higher than 6.5%, or if you take medications that affect your blood sugar, weight, or digestion (such as steroids or certain psychiatric medicines). People who have had major surgery or spent time in hospital in the last three months are also unable to join.
Because the researchers need to measure natural changes, you should not be on a strict diet (such as a keto diet), have lost more than 5% of your body weight recently, or be planning any sudden fitness changes. You must also be a non-smoker, drink no more than 14 units of alcohol per week, and avoid taking blood sugar supplements like cinnamon, berberine, or chromium.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- I am between 18 and 60 years old.
- My BMI is between 25 and 29.9 (overweight range).
- I do not have diabetes and my blood sugar levels are normal.
- I am not currently on a strict diet and have not had large weight changes recently.
- I do not smoke and drink 14 units of alcohol or fewer per week.
- I can travel to Headington, Oxford for three clinic appointments.
What does participation involve?
Taking part in the study lasts for 12 weeks. You will be randomly assigned by chance (like flipping a coin) to take either the Reducose® mulberry extract or a matching dummy capsule (placebo) every day.
You will need to visit the Oxford Brookes Centre for Nutrition and Health in Headington three times. During these visits, researchers will measure your height, weight, body fat, and blood pressure, and take standard blood samples. You will be fitted with a continuous glucose monitor (a tiny, painless sensor worn on the back of your arm) to track your blood sugar levels as you go about your normal daily routine. You will also be asked to collect a small stool sample at home to test your gut bacteria and fill out brief surveys about your hunger and fullness after eating.
Potential risks and benefits
Locations (1)
- Oxford Brookes Centre for Nutrition and Health (OxBCNH)City onlyOxford, England
Common questions
What is Reducose®?
Reducose® is a plant-based extract made from white mulberry leaves, designed to be taken with food to help slow down how quickly your body digests carbohydrates.
Will I definitely receive the mulberry extract?
No. Half of the participants will receive Reducose® and the other half will receive an inactive dummy pill (placebo) so researchers can fairly compare the results.
Do I have to pay to take part?
No, taking part is completely free. You will also receive Amazon vouchers to thank you for giving up your time.
Where does the study take place?
All in-person visits take place at the Oxford Brookes Centre for Nutrition and Health in Headington, Oxford.
Can I leave the study if I change my mind?
Yes. You can withdraw from the trial at any time, for any reason, and it will not affect your regular medical care.
How to find out more
Andrew Gallagher
Always speak to your GP or specialist before deciding to take part in a study.
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