RecruitingNAINTERVENTIONAL

Contribution of New Pancreatic MRI Sequences for the Evaluation of Tumor Response in Pancreatic Adenocarcinomas

This research is exploring new and advanced ways to use MRI scans to better understand how a type of pancreatic cancer, called pancreatic adenocarcinoma, responds to treatment. This particular cancer can be challenging, so finding better ways to track tumour changes is very important. The study uses special MRI techniques, including 'magnetic resonance elastography' (MRE) and high-resolution diffusion sequences. These advanced scanning methods help doctors get a more detailed view of the tumour. By taking part, you would help scientists learn if these new MRI methods can provide clearer information about how the cancer is reacting to therapies, which could ultimately lead to better care for future patients.

At a glance

Status

Recruiting

Phase

Sponsor

Central Hospital, Nancy, France

Enrolment target

120

Start

06 Jun 2025

Estimated completion

06 Jun 2027

Pancreas Adenocarcinomas

What is this study about?

This research study is about finding better ways to track a type of pancreatic cancer called pancreatic adenocarcinoma. This particular cancer can be very challenging, and doctors are always looking for improved methods to see if treatments are working as they should.

Currently, assessing how well a tumour is responding to treatment can be difficult. This study introduces new, advanced types of MRI scans that might give a clearer picture. These include 'magnetic resonance elastography' (MRE) and a special high-resolution 'diffusion sequence'. MRE looks at the stiffness of tissues, which can be different in healthy and cancerous areas. The high-resolution diffusion sequence helps to see how water moves in tissues, which can also change when a tumour is present or responding to treatment.

The main goal is to see if these new MRI techniques can provide more useful information than standard scans. If they do, it could help doctors make more informed decisions about treatment plans for people with pancreatic cancer in the future, potentially leading to better outcomes.

Key takeaways

This study uses new MRI techniques to look at pancreatic cancer.
It aims to find better ways to see if cancer treatments are working.
Participants must have pancreatic cancer that hasn't spread.
The study involves advanced MRI scans, no new medication.
It helps researchers, potentially improving future patient care.

Who may be eligible?

To join this study, you must have been diagnosed with pancreatic cancer that hasn't spread to other parts of your body, as shown by a CT scan. You need to be 18 years old or older and be covered by a social security system, meaning you live in a country with a national healthcare system like the NHS.

There are certain reasons why you wouldn't be able to take part. For example, if you can't have an MRI scan for medical reasons (such as having certain metallic implants), then this study wouldn't be suitable for you. Also, if you are pregnant, breastfeeding, or a minor (under 18), you can't join. This also applies to anyone who is under legal protection (like guardianship) or unable to give their own consent to participate.

Finally, if you are in prison or receiving compulsory psychiatric care, you wouldn't be able to take part in this research.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Have I been diagnosed with pancreatic cancer that hasn't spread?
Am I 18 years old or older?
Do I have no medical reasons preventing an MRI scan?
Am I NOT pregnant or breastfeeding?
Am I able to give my own consent to join a study?

Answer every question to see your result.

What does participation involve?

The detailed information for participation was not fully provided. However, generally, if you take part in a study like this, you would likely have one or more special MRI scans using the new techniques mentioned – magnetic resonance elastography (MRE) and a high-resolution diffusion sequence. These scans would be done in addition to any routine scans you might already be having as part of your treatment plan. You wouldn't be given any new medication specifically for this study. The total duration of your involvement would depend on how many scans are needed and over what period, but this information isn't fully detailed here. You would also need to sign a consent form after being given full information about the study.

Potential risks and benefits

Taking part in this study could help researchers learn more about how to better track pancreatic cancer, which ultimately could improve care for future patients. For you, there's no direct treatment benefit from these scans, but you might gain a better understanding of your own condition. The main risks involve those generally associated with MRI scans, such as claustrophobia, or reactions to the contrast dye if used (though not mentioned here). There are no new medications involved. You always have the right to withdraw from the study at any time without it affecting your medical care.

Locations (1)

CHRU Nancy
Verified postcode
Vandœuvre-lès-Nancy, France· Recruiting

Common questions

What is pancreatic adenocarcinoma?

It's a common and serious type of cancer that starts in the pancreas, an organ behind your stomach.

What is an MRI scan?

MRI stands for Magnetic Resonance Imaging. It's a type of scan that uses strong magnets and radio waves to create detailed pictures of organs and structures inside your body.

What are 'new MRI sequences'?

These are advanced ways of performing and analysing MRI scans to get even more detailed information about tissues, like how stiff they are or how water moves within them.

Will taking part change my cancer treatment?

No, this study is about gathering information. It won't directly change your current cancer treatment plan.

Do I have to do anything special to prepare for the scans?

You will be given specific instructions by the hospital if you take part. Generally, you'll need to remove any metal objects before an MRI.

How to find out more

Guillaume DROUOT, PhD

g.drouot@chru-nancy.fr 0385157666 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.