Sotorasib Combined With First-line Chemotherapy for Advanced Pancreatic Adenocarcinoma

To join this study, you must be 18 years or older and have been diagnosed with advanced pancreatic cancer that has not been treated before with chemotherapy. Importantly, your cancer must also have a specific genetic change called KRAS G12C mutation, which will be found through a special test. Doctors need to be able to measure your cancer, and you should be generally well enough to take part, as decided by a doctor, with an estimated life expectancy of more than three months.

There are also specific blood test results needed to make sure your body organs, like your liver and kidneys, are working well enough for you to safely receive the study treatments. Both men and women can take part. If you are able to have children, you would need to use effective birth control during and for a period after the study to prevent pregnancy.

You would not be able to join if you have already had chemotherapy for your pancreatic cancer, or if your health isn't considered strong enough for the treatments. The research team will review all specific medical conditions and test results to decide if this study is right for you.

If you join this study, you'll first have a 'screening period' where tests are done to make sure you're suitable. Once you're approved, you'll start the 'treatment period'. You'll be given sotorasib as a tablet to take once a day for 28 days (4 weeks) at a dose of 960 mg, along with either gemcitabine plus nab-paclitaxel, or modified FOLFIRINOX chemotherapy, as chosen by your doctor. You'll have regular visits to the hospital for your chemotherapy, check-ups, and to see how you're responding to the treatment.

During the study, doctors and nurses will closely monitor you for any side effects and how your body handles the medication. After your treatment ends, there will be follow-up periods to keep an eye on your health and any effects of the treatment, both for safety and for a longer time to see how you're doing. You might need to stop treatment if your cancer gets worse, if you can't tolerate the side effects, or if you decide you no longer want to participate.