Population Pharmacokinetics of Anti-infectives in Hospitalized Patients
This research focuses on making sure patients in the hospital get the best possible dose of anti-infective medicines. These medicines are crucial for fighting serious infections, especially in conditions like sepsis, where getting the right treatment quickly is vital. We know that these medicines can work differently in different people, for example, based on their illness, age, or other medicines they're taking. This study uses special mathematical tools to understand how the medicines move through the body and what effects they have. The aim is to create personalised treatment plans so that each patient receives the most effective dose for their specific needs, helping them recover better and faster.
At a glance
What is this study about?
This study is all about making sure anti-infective medicines, like antibiotics, work as well as possible for patients in the hospital. When someone has a serious infection, such as sepsis, getting the right amount of medicine into their body quickly is extremely important for their recovery. However, we know that these medicines don't always work the same way in everyone.
Many things can affect how a medicine works, such as a patient's age, weight, the severity of their illness, or even other medicines they're taking. This means that a standard dose might not be ideal for every individual. This research uses advanced methods, including mathematical modelling, to carefully study how these anti-infective medicines behave in the body and what effects they have. The team, including experts in medicine and pharmacology, wants to find the best way to tailor treatments.
The main goal is to understand these differences better and develop personalised dosing plans. By doing this, doctors can ensure that each patient receives the most effective amount of medicine, leading to better outcomes, faster recovery, and a stronger fight against infection. The overall aim is to improve how we use these vital medicines in hospital settings.
Key takeaways
- Aims to improve how anti-infective medicines work for hospital patients.
- Focuses on serious infections like sepsis.
- Uses routine patient data, no extra tests or treatments.
- Seeks to create personalised medicine doses.
- Could help future patients get better, faster care against infections.
Who may be eligible?
To be considered for this study, you would be an adult who is currently staying in Cochin hospital and is receiving an anti-infective medicine. This could be an antibiotic or another type of medicine used to fight infection.
A key part of deciding if you can take part is whether your doctor needs to measure the amount of the anti-infective medicine in your body fluids, like your blood. This is a routine part of your care and helps doctors ensure the medicine is working correctly.
You would not be able to join the study if you had previously told your doctor or the hospital that you do not want your routine medical information or samples collected for research purposes.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you an adult (18 years or older)?
- Are you currently staying in Cochin hospital?
- Are you receiving an anti-infective medicine?
- Does your doctor need to measure the medicine levels in your body fluids?
- Have you agreed to your routine medical information being used for research?
What does participation involve?
This study is 'non-interventional', which means you won't undergo any extra tests, receive new medicines, or have additional appointments specifically for the research. Instead, the researchers will use information that is already being collected as part of your standard medical care in the hospital. This includes information about the anti-infective medicines you're receiving and any measurements of these medicines in your body fluids. There's no specific follow-up period for the study itself; it uses data gathered during your hospital stay. Your doctor will continue to manage your care as usual.
Potential risks and benefits
Locations (1)
- Cochin HospitalVerified postcodeParis, France· Recruiting
Common questions
What kind of medicines are 'anti-infectives'?
Anti-infectives are medicines used to fight infections, like antibiotics that treat bacterial infections, or antifungal medicines that treat fungal infections.
What does 'personalised dosage' mean?
It means adjusting the amount of medicine you receive to specifically suit your body and your infection, rather than giving a standard dose to everyone. This helps the medicine work better for you.
Will I have extra blood tests if I join?
No, this study only uses information that is already being collected during your routine hospital care, including any blood tests your doctor orders for your treatment.
Will taking part affect my treatment?
No, your medical team will continue to treat you as they normally would. The study will not change your care or the medicines you receive.
Who is running this study?
This study is a collaboration between the Antimicrobial Stewardship Team and the Pharmacology department at Cochin hospital, part of the APHP Centre hospital group in France.
How to find out more
Etienne CANOUI, MD
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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