RecruitingPhase IInterventional

A novel collagen-based dressing to use in bleeding wounds

This study is looking at a new dressing called CLOTTA™ that aims to quickly stop bleeding. Bleeding heavily from injuries can be very dangerous, so finding quick ways to stop it is important. CLOTTA™ has been used on animals successfully, and now we need to check if it's safe and effective for people. We're asking adults who come to the Queen Elizabeth Hospital's emergency department with a single bleeding wound if they would like to take part. Researchers will apply the dressing and watch closely to see if it stops the bleeding, and they'll check for any reactions. Your involvement will help medical teams understand more about treating bleeding wounds in the future.

At a glance

Status

Recruiting

Phase

Phase I

Sponsor

Depletura Ltd

Enrolment target

Start

01 Jun 2026

Estimated completion

31 May 2027

Patients with a single actively bleeding wound

What is this study about?

Imagine you've had an accident and have a bleeding wound. Getting the bleeding to stop quickly is really important for your health and recovery. Around the world, many people get injured every day, from everyday accidents to more serious situations, and stopping heavy bleeding is often key to saving lives and preventing further problems.

This study is testing a new dressing called CLOTTA™. It's made from a natural material found in the body called collagen. This dressing has already been used with success in animals to stop bleeding, but before it can be used widely for people, we need to make sure it's both safe and works well. That's why we're doing this study at a hospital, to gather important information.

By taking part, you'd be helping doctors and researchers learn more about how to treat bleeding wounds. The information we gather from this study will help us understand if CLOTTA™ could be a new and better way to help people with injuries in the future.

Key takeaways

This study tests a new bleeding control dressing (CLOTTA™).
It aims to see if CLOTTA™ is safe and effective for people.
It's for adults (18+) with a single, actively bleeding wound.
You participate during your emergency department visit.
Potential risk – allergic reaction, especially if allergic to meat/eggs.
Your involvement helps improve future wound care.

Who may be eligible?

You might be able to join this study if you are 18 years old or older and come to the Emergency Department at Queen Elizabeth Hospital with a single wound that is actively bleeding and needs a dressing to help it stop.

However, you won't be able to take part if you are under 18, have several injuries, or if you are pregnant. Also, if you know you have an allergy to meat products or eggs, you won't be able to join this study. This is because the dressing uses an ingredient from poultry, which could cause a reaction in people with these allergies.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have a single wound that is actively bleeding?
Are you currently at the Queen Elizabeth Hospital Emergency Department?
Do you have any known allergies to meat products or eggs? (If yes, you cannot join.)
Are you pregnant or think you might be? (If yes, you cannot join.)

Answer every question to see your result.

What does participation involve?

If you decide to take part, a member of the study team will explain everything to you and answer any questions you have before you agree. Once you agree, we will apply the CLOTTA™ dressing to your bleeding wound. A study team member will stay with you for 10 minutes to closely watch the dressing to see if any blood comes through. If it does, we'll note down how long it took. After the dressing is removed, we'll check your skin for any reactions and ask you how comfortable it felt. After this, your involvement in the study will be complete, and some information will be collected from your hospital records. There are no follow-up visits after this initial application.

Potential risks and benefits

While we cannot promise any direct health benefits to you by taking part, your contribution will be very valuable. The information we learn will help doctors understand more about treating bleeding wounds and could lead to better treatments for others in the future. The dressing uses a natural material, so serious risks are very low. However, because it contains an ingredient from poultry, there's a small chance of an allergic reaction, especially if you already have allergies to meat or eggs. Since you will be in the hospital, if any reaction occurs, doctors will be there to treat it right away. You are always free to change your mind and leave the study at any time, for any reason.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

University Hospitals Birmingham NHS Foundation Trust
City only
Birmingham, England

Common questions

What is CLOTTA™?

CLOTTA™ is a new type of dressing made from collagen that is being tested to see if it can help stop bleeding from wounds quickly.

Who is paying for this study?

Depletura Ltd, the company that makes the CLOTTA™ dressing, is funding this study.

Where is this study taking place?

This study is being run at the Queen Elizabeth Hospital in Birmingham, UK.

Will I get any special treatment if I join?

While we can't guarantee you personal medical benefits, your participation will help doctors learn more about treating bleeding wounds, which could benefit many people in the future.

Can I leave the study at any time?

Yes, you are free to leave the study at any point, for any reason, without it affecting your medical care.

How to find out more

Hazel Smith

hazel.smith@uhb.nhs.uk +44 (0)7789 933031 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.