MRI Screening of Placenta Adhesion Abnormalities
This study is investigating a special type of MRI scan for pregnant women. The aim is to see if this advanced MRI can better detect a condition called Placenta Adhesion Abnormalities (PAA). PAA happens when the placenta attaches too deeply into the womb. If not known about before birth, it can lead to serious problems like heavy bleeding or needing a hysterectomy during delivery. While ultrasound is the usual way to spot PAA, it's not always clear. This study hopes to find out if specific measurements from the advanced MRI, which doesn't use injections, can more accurately show how well the placenta is working. This could help doctors better prepare for deliveries and keep both mother and baby safer.
At a glance
What is this study about?
When a woman is pregnant, the placenta is very important because it provides food and oxygen to the baby. Sometimes, the placenta can grow too deeply into the wall of the womb. Doctors call this Placenta Adhesion Abnormalities, or PAA for short. If doctors don't know about PAA before the baby is born, it can cause very serious problems during delivery, such as a lot of bleeding, needing surgery to remove the womb (a hysterectomy), or even, in rare and extreme cases, a risk to the mother's life. We want to find better ways to spot this condition.
Currently, doctors mainly use ultrasound scans to look for PAA. However, sometimes the ultrasound pictures aren't clear enough, and it's hard to be sure if PAA is present. This is where MRI scans can come in. While standard MRI scans haven't always given much better information than ultrasound for this specific problem, we believe a more advanced type of MRI might be more helpful. This special MRI looks at things like blood flow and oxygen levels in the placenta, without needing any injections.
The main goal of this study is to see how good this advanced MRI is at finding PAA in pregnant women who are between 30 and 38 weeks along. We are specifically looking at women who have certain risk factors that make PAA more likely. By understanding if this MRI can give clearer and more accurate information, we hope to help doctors plan the safest possible delivery for mothers and babies, reducing the risk of unexpected problems.
Key takeaways
- Study examines new MRI to spot placenta problems.
- Aims to improve safety for mums with Placenta Adhesion Abnormalities (PAA).
- Looks at detailed placenta function without injections.
- Focuses on pregnant women with known PAA risk factors.
- Participation helps advance understanding of PAA detection.
Who may be eligible?
This study is looking for pregnant women who are between 30 and 38 weeks pregnant and are at least 18 years old. You need to have had all your usual medical checks, understand what the study involves, and agree to take part by signing a consent form. You also need to be planning to give birth at the CHRU of Nancy hospital in France.
To be considered for this study, you must also have certain risk factors for PAA. This means you might have a placenta that is positioned very low in the womb, covering the cervix, or sitting over a scar from a previous womb surgery (like a C-section).
You won't be able to join the study if you are pregnant with more than one baby (like twins or triplets), or if you have any health conditions that would make having an MRI scan unsafe for you. Also, if you find it hard to understand or follow study instructions, or if you fall under specific legal categories regarding research participation in France, you wouldn't be able to take part.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you between 30 and 38 weeks pregnant?
- Are you 18 years old or older?
- Do you plan to give birth at CHRU of Nancy?
- Does your placenta have a low position, cover your cervix, or sit over a C-section scar?
- Do you have no medical reasons preventing an MRI scan?
- Can you understand and follow study instructions?
What does participation involve?
If you decide to take part in this study, you will have a specific type of MRI scan. This scan will likely happen when you are between 30 and 38 weeks pregnant. The MRI machine is a large tunnel, and you'll lie still inside it for a period. This scan does not involve any injections. There won't be any new medication given as part of this study. You will have a follow-up after the scan, but the study primarily focuses on this single MRI assessment. We will explain everything in detail, and you'll have a clear understanding of what to expect during your visit.
Potential risks and benefits
Locations (1)
- Centre Hospitalier Régional Universitaire de NancyVerified postcodeVandœuvre-lès-Nancy, France· Recruiting
Common questions
What is PAA?
PAA stands for Placenta Adhesion Abnormalities. It's when the placenta attaches too deeply into the wall of your womb during pregnancy.
Why is PAA a problem?
If doctors don't know about PAA before birth, it can cause serious bleeding during delivery, which might mean needing a hysterectomy (womb removal) or other urgent treatments.
What's different about this MRI scan?
This study uses a special kind of MRI that looks at how well the placenta is working, by measuring things like blood flow and oxygen levels, without needing any injections.
Does the MRI involve radiation?
No, MRI scans use strong magnets and radio waves, not radiation like X-rays, so it's considered safe for pregnancy when performed under proper guidelines.
Will I get my scan results?
The study aims to gather information for research. Your own doctors will discuss your overall pregnancy care with you based on all your medical results.
How to find out more
Charline BERTHOLDT, MI
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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