Effects of Reducose®, a mulberry leaf extract formulation, on post-meal glycaemic control, insulin response, satiety, and appetite regulation in healthy adults (SATISPHY)
The SATISPHY study is exploring how a natural supplement made from mulberry leaf extract, known as Reducose®, impacts healthy adults. Specifically, researchers want to see if this supplement can help control blood sugar and insulin levels after eating a meal. They're also investigating if it affects how full people feel and their overall appetite. Participants will try Reducose®, another similar plant-based formula, and a placebo (dummy pill) on different days. The aim is to understand if these natural ingredients could offer new ways to manage blood sugar and appetite in the future. It's for healthy adults aged 18 and over, without diabetes, and involves a few short visits to the study centre.
At a glance
What is this study about?
Imagine you've just eaten a meal. Your body naturally processes the food, and your blood sugar and insulin levels change. This study, called SATISPHY, is investigating whether a natural supplement made from mulberry leaves, called Reducose®, can help manage these changes.
The researchers want to see if taking Reducose® before a meal can lead to lower blood sugar and insulin spikes after eating. They're also very interested in how it affects your feelings of hunger and fullness. Could it help you feel satisfied for longer? They'll be comparing Reducose® to a similar mulberry-based formula and a 'dummy' pill (placebo) which contains no active ingredients. This helps them understand if any effects are truly from the supplements or just from expectation.
The main goal of this research is to discover if natural ingredients like mulberry leaf extract could offer a gentle way to help people manage their blood sugar and appetite in the future. The findings could be important for developing new, non-medical approaches to help more people stay healthy.
Key takeaways
- Exploring natural ways to control blood sugar and appetite.
- Compares mulberry leaf extract (Reducose®) to a placebo.
- Involves three short morning visits with blood tests and questionnaires.
- For healthy adults aged 18 and over, without diabetes.
- Small risks, potential for future health insights.
- Study is double-blind, so you won't know which capsule you take.
Who may be eligible?
This study is looking for healthy men and women aged 18 and over. To join, you should be generally healthy, not have diabetes, and have blood sugar levels within a normal range when you haven't eaten. Your weight should also be within a healthy or slightly overweight range (BMI between 18.5 and 30).
There are certain reasons why you might not be able to take part. For example, if you have a known food allergy, are currently on certain medications that affect blood sugar, or have recently been in hospital for a major illness or surgery. The study also isn't suitable if you're trying to lose weight with a specific diet, drink a lot of alcohol, or use nicotine products.
It's important that you're willing and able to follow all the study instructions and are happy to give your permission to be part of the research.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Do you consider yourself generally healthy?
- Do you *not* have diabetes?
- Are you able to visit the University of Westminster for three mornings?
- Are you willing to have blood samples taken?
- Are you *not* on a specific diet for weight loss?
What does participation involve?
If you decide to join this study, you'll visit the research centre three separate times. Each visit will be in the morning after you've fasted overnight (meaning you haven't eaten anything). At each visit, you'll take either the Reducose® supplement, the other plant-based formula, or a placebo (a dummy pill) – you won't know which one you're getting, and neither will the researchers. After taking the capsule, you'll eat a standard breakfast meal.
Over the next three hours, small blood samples will be taken at different times to measure your blood sugar and insulin levels. You'll also fill out short questionnaires about how hungry or full you feel, and how you perceive the food. Before and after each visit, you'll be asked to recall what you've eaten in the last 24 hours. Each visit will last about four hours, and there will be at least two days between each visit.
Potential risks and benefits
Locations (1)
- Centre of NutraceuticalsCity onlyLondon, England
Common questions
What is Reducose®?
Reducose® is a special extract made from mulberry leaves that researchers believe might help control blood sugar.
What is a 'placebo'?
A placebo is a 'dummy' pill that looks just like the real supplement but contains no active ingredients. It helps researchers compare effects fairly.
Will I know if I'm taking the real supplement or the placebo?
No, this is a 'double-blind' study, meaning neither you nor the research team will know which capsule you receive during each visit. This helps make the study results more reliable.
Do I need to be on a special diet to join?
No, you don't need a special diet. However, if you are actively trying to lose weight through dieting, you won't be able to participate.
How long will the study run for?
The study is planned to take place between March 2026 and December 2026.
How to find out more
Preeti Jethwa
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
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