Graduated compression stockings for patients with a deep vein thrombosis to prevent long-term symptoms, known as post-thrombotic syndrome
A deep vein thrombosis (DVT) is a blood clot that usually forms in a deep vein of the leg. Around half of the people who have a DVT go on to develop lasting problems, such as persistent swelling, aching, skin changes, or ulcers. This is known as post-thrombotic syndrome. Doctors are running this study to find out if wearing snug, graduated compression stockings can prevent these long-term issues. In this UK-wide trial, adults recently diagnosed with their first leg DVT are split into two groups. Everyone takes standard blood-thinning medicine, but one group also receives custom-fitted stockings to wear during the day for up to 30 months. The study aims to provide clear evidence for the NHS about whether compression stockings improve recovery, while offering all participants close medical monitoring and expert support.
At a glance
What is this study about?
A deep vein thrombosis, often called a DVT, is a blood clot that forms in the deep veins of the body, most commonly in the leg. While standard blood-thinning medicines prevent the clot from growing and give the body time to clear it, the vein can still be left damaged. Because of this, roughly one in two patients develops long-term complications known as post-thrombotic syndrome. This condition can lead to persistent leg aching, swelling, heaviness, and in some cases, painful skin sores called leg ulcers.
At present, doctors around the world are not completely certain whether wearing compression stockings prevents these lasting symptoms. Graduated compression stockings are specially designed, elastic garments that gently squeeze the leg, with the firmest pressure at the ankle. This squeeze encourages blood to flow upward toward the heart. While some smaller studies suggest stockings are helpful, other studies disagree, leaving patients and doctors unsure of the best choice.
The CHAPS trial, led by Imperial College London and funded by the National Institute for Health Research, was set up to provide a definite answer. By comparing standard care with compression stockings across a large group of NHS patients, the researchers hope to understand whether wearing stockings gives people a better quality of life and keeps legs healthy for years to come.
Key takeaways
- Tests whether compression stockings prevent lasting leg pain and swelling after a DVT.
- Open to adults diagnosed with their first leg DVT in the last two weeks.
- Participants take blood thinners, and half are randomly chosen to also wear stockings.
- Free fitting aids, videos, and regular check-ups are provided to support you.
- Joining is completely voluntary and will not affect your standard NHS care.
Who may be eligible?
This study is open to adults aged 18 and older who have been diagnosed with their very first leg DVT within the past two weeks. The clot must be confirmed by an ultrasound or hospital scan in the main veins of the leg or pelvis. Participants also need to be able to understand the study details and give their consent to join.
The trial is not suitable for people who have had a DVT before, have clots in both legs at the same time, or already live with chronic leg swelling, severe arthritis, or existing skin ulcers. It also excludes individuals with poor blood circulation in their leg arteries, active cancer, fabric allergies to stockings, or any medical condition that makes blood-thinning medicine unsafe.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- I am aged 18 or older.
- I was diagnosed with my first DVT in one leg within the last 14 days.
- My clot was confirmed by a hospital scan.
- I do not have poor blood flow or blocked arteries in my legs.
- I do not have active cancer or existing leg ulcers.
What does participation involve?
If you decide to take part, a computer will randomly place you into one of two groups. Everyone receives standard NHS blood-thinning medicine. One group takes this medication alone, while the other group takes the medication and wears a fitted compression stocking during the day for between 6 and 30 months.
If you are in the stocking group, you will receive free tools to help put them on, video guides, and weekly text reminders. Different styles are available, including cooler cotton options for warm weather. You will have regular check-ups where nurses check your leg health and test the blood flow in your arteries. You will be asked not to wear your stocking on the day of your clinic visits so the researchers can examine your legs without knowing which group you are in. Your total involvement will last between 6 and 30 months.
Potential risks and benefits
Locations (24)
- Imperial College Healthcare NHS TrustCity onlyLondon, England
- Guy's and St Thomas' NHS Foundation TrustCity onlyLondon, England
- King's College Hospital NHS Foundation TrustCity onlyLondon, England
- University Hospitals Birmingham NHS Foundation TrustCity onlyBirmingham, England
- Royal Free London NHS Foundation TrustCity onlyLondon, England
- London North West University Healthcare NHS TrustUnverifiedHarrow, England
- Hampshire Hospitals NHS Foundation TrustUnverifiedBasingstoke, England
- Basildon and Thurrock University Hospitals NHS Foundation TrustUnverifiedBasildon, England
- The Newcastle Upon Tyne Hospitals NHS Foundation TrustUnverifiedNewcastle-upon-Tyne, England
- East Cheshire NHS Trust,UnverifiedMacclesfield, England
- Salisbury NHS Foundation TrustUnverifiedSalisbury, England
- Barking, Havering and Redbridge University Hospitals NHS TrustUnverifiedRomford, England
Common questions
What is post-thrombotic syndrome?
It is a long-term condition that can develop after a blood clot in the leg, causing persistent aching, swelling, skin discoloration, and sometimes open sores.
Can I choose whether I receive the stockings?
No. A computer randomly decides your group to make sure the trial results are completely fair and reliable.
Do I have to wear the stocking in bed?
No, participants are only asked to wear the stocking during the day while they are awake and out of bed.
What if I find the stockings difficult to put on?
The study team provides free practical devices, video guides, and hands-on training to make putting them on much easier.
Do I need to pay for the stockings or equipment?
No, all stockings, fitting aids, and study appointments are provided free of charge through the NHS research programme.
How to find out more
Rebecca Lawton
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
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