All studies
RecruitingNAINTERVENTIONAL

Prehabilitation for Colorectal Cancer Patients With Low Functional Capacity and Malnutrition

This study is for older people having bowel cancer surgery who are not getting enough nutrition and have signs of physical frailty, such as reduced physical function. Previous research has shown that many patients in this situation do not improve their physical fitness before surgery, even when they take part in prehabilitation programs. Researchers think that poor nutrition may be one reason why some physically frail patients have difficulty improving their fitness before their operation. This trial will compare two groups: one receiving nutrition support and another receiving both nutrition support and exercise guidance. The main goal is to see which approach helps patients improve how far they can walk before surgery, which is an important measure of physical function. The study hopes to identify the best way to help physically frail patients prepare for surgery and support their recovery afterward.

At a glance

Status
Recruiting
Phase
NA
Sponsor
McGill University
Enrolment target
60
Start
31 Jan 2022
Estimated completion
01 Dec 2026

What is this study about?

When you're preparing for a big operation like bowel cancer surgery, being as fit and healthy as possible can really help with your recovery. Sometimes, older patients or those with cancer might find themselves a bit undernourished (meaning they're not getting all the nutrients their body needs) and not as strong or active as they could be. This can make surgery and recovery a bit tougher.

We already know that trying to get stronger and fitter before surgery, often called 'prehabilitation', can be helpful. This usually involves a mix of good food, exercise, and sometimes emotional support. However, what we've found is that some people, especially older patients who are already not very strong, still struggle to get fit enough before their operation. A key observation was that many of these patients who weren't getting fitter were also undernourished.

This study wants to explore if the main reason for not being strong enough in these cases is actually the lack of good nutrition. We're testing two approaches: one group will focus on improving their nutrition with advice and support, and the other group will do the same but also include some supportive exercise. The main aim is to see which method helps patients improve their physical fitness, specifically how far they can walk in six minutes. This helps us understand if fixing nutrition alone can make a big difference, or if exercise needs to be part of the plan too. The results of this study will help doctors and nurses give the best possible advice and care to patients like you, helping to make your surgery and recovery as smooth as possible.

Key takeaways

  • A study for older bowel cancer patients needing surgery.
  • Aims to improve fitness and nutrition before an operation.
  • Compares nutrition support alone versus nutrition plus exercise.
  • Hopes to find the best way to help patients recover well.
  • Participation involves monitoring your diet and fitness.

Who may be eligible?

This study is open to people aged 65 or older who are scheduled to have surgery for bowel cancer. You would also need to have shown that you're currently not as fit as you could be (for example, not able to walk 400 metres in six minutes at the start of the study) and have signs of being undernourished.

However, you wouldn't be able to join if you have certain existing health conditions that would make exercise unsafe, such as severe memory problems (like dementia), Parkinson's disease, or if you've had a stroke that has left you with significant weakness on one side of your body. Also, it's not for people whose cancer has spread to other parts of their body (metastatic cancer) or if you don't speak English or French and can't have someone who speaks one of those languages with you to help with communication.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you 65 years old or older?
  2. Are you having surgery for bowel cancer?
  3. Do you feel you're not as fit as you could be?
  4. Have you been told you might be undernourished?
  5. Do you NOT have conditions like severe dementia or uncontrolled Parkinson's that make exercise risky?
  6. Is your cancer NOT spread to other parts of your body?
Answer every question to see your result.

What does participation involve?

If you join this study, you'll be randomly assigned to one of two groups: either focusing on improving your nutrition, or improving your nutrition alongside some exercise. Both groups will receive guidance and support throughout the study. Your fitness will be checked regularly, including how far you can walk in six minutes. Researchers will also monitor how well you're able to follow the advice given. The total duration of your involvement in the study would be the time leading up to your surgery.

Potential risks and benefits

Taking part in this study may offer personal benefits by helping you to improve your fitness and nutrition before surgery, potentially leading to a better recovery. The information gained will also help us understand the best ways to prepare future patients for surgery. While the interventions like nutrition advice and supportive exercise are generally safe, there's always a small chance of minor discomfort from physical activity. You are free to withdraw from the study at any time without giving a reason, and your medical care will not be affected.

Locations (2)

  • MUHC Research Ethics Board
    Verified postcode
    Montreal, Canada· Recruiting
  • Montreal General Hospital
    Unverified
    Montreal, Canada

Common questions

What is 'prehabilitation'?

Prehabilitation means getting you as fit and healthy as possible before surgery to help with your recovery.

What does 'malnutrition' mean in this study?

It means your body isn't getting enough of the right nutrients, which can affect your strength and health.

Will I have to do difficult exercise?

The exercise will be supportive and tailored, aiming to improve your fitness without being too strenuous.

How long will I be in the study?

You'll be part of the study from when you join until your surgery.

What is the 6-minute walking test?

It's a simple test where you walk as far as you can in six minutes to measure your fitness level.

How to find out more

Chelsia Gillis, RD PhD

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "Prehabilitation for Colorectal Cancer Patients With Low Func…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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