REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI
The REVIVe study explores how frailty, a medical condition causing reduced health, impacts adults and children who experience severe breathing illnesses like COVID-19. Many such patients need intensive care. Researchers want to understand if frail patients are less likely to survive or have more health issues after leaving the hospital, compared to those without frailty. They are also looking into how different types of rehabilitation, like physical therapy, can help survivors recover their strength and quality of life. The study will gather information about patients in intensive care, including details from before and during their illness. The aim is to help improve care and support for people recovering from these serious illnesses.
At a glance
What is this study about?
This research, called REVIVe, is looking into how a condition called 'frailty' affects people who get very sick with COVID-19 or other serious lung infections. Frailty means someone's body is less able to cope with illness and stress, often due to age or other health problems. Many adults and some children with these infections can become so unwell they need to be treated in an Intensive Care Unit (ICU), which is where doctors provide very advanced life support.
The study has two main goals. Firstly, it wants to find out if adults and children who are frail when they get seriously ill with COVID-19 or another acute respiratory infection are less likely to survive. It also wants to see if they experience more health problems or have a harder time recovering afterwards compared to patients who are not frail. Secondly, the researchers want to learn about the different kinds of rehabilitation – like exercises and therapies – that patients receive to help them get back on their feet. Understanding this better can help doctors and nurses plan better care in the future.
This research is really important because COVID-19 has affected so many people worldwide. By understanding how serious illnesses like COVID-19 impact people who are more vulnerable, especially those who are frail, we can improve the care they receive. The results of this study could help hospitals and policymakers plan better recovery services after people leave the hospital, make sure healthcare workers know how important rehabilitation is, and even help develop new treatments to improve people's lives after they've been very sick.
Key takeaways
- This study focuses on how frailty affects recovery from severe lung infections.
- It covers both adults and children who needed intensive care.
- Researchers want to see if frailty leads to lower survival rates or more health problems.
- They are also studying the types of rehabilitation that help patients recover.
- Participation involves reviewing medical records, not new procedures.
- The goal is to improve care for future patients battling serious respiratory illnesses.
Who may be eligible?
This study is looking for adults and children who have been very sick with COVID-19 or another serious breathing infection and needed special care in an Intensive Care Unit (ICU).
To be included, adults must be 18 years or older, and children must be under 18 years old. They need to have had a confirmed diagnosis of COVID-19 or another acute respiratory infection that started within 14 days of being admitted to the ICU. This serious breathing infection must have required special breathing support, such as a breathing machine or high-flow oxygen.
Patients will not be included if they were in the ICU for less than 24 hours. This helps ensure that the study focuses on people who experienced a significant period of critical illness.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Were you an adult (18+) or child (under 18) admitted to intensive care?
- Did you have a confirmed COVID-19 or another serious breathing infection?
- Did your breathing infection start within 14 days of being admitted to intensive care?
- Did you need special breathing support, like a ventilator or high-flow oxygen?
- Were you in intensive care for at least 24 hours?
What does participation involve?
This study won't involve any extra treatments or changes to your usual medical care. Instead, the researchers will collect information from your existing medical records from before and during your stay in the Intensive Care Unit (ICU). They will look at things like your level of frailty (how well your body copes with illness), how well you were functioning, and the types of therapy or rehabilitation you received while recovering. You won't need to attend any extra appointments or take any new medications just for this study.
Potential risks and benefits
Locations (28)
- Alberta Children's HospitalVerified postcodeCalgary, Canada· Active not recruiting
- University of AlbertaVerified postcodeEdmonton, Canada· Recruiting
- Sturgeon Community HopsitalVerified postcodeSt. Albert, Canada· Not yet recruiting
- Royal Columbian HospitalVerified postcodeNew Westminster, Canada· Not yet recruiting
- Children's Hospital of WinnipegVerified postcodeWinnipeg, Canada· Active not recruiting
- QEII Health Sciences CentreVerified postcodeHalifax, Canada· Recruiting
- Izaak Walton Killam Hospital for ChildrenVerified postcodeHalifax, Canada· Recruiting
- Brantford General HospitalVerified postcodeBrantford, Canada· Recruiting
- Hamilton General HospitalVerified postcodeHamilton, Canada· Recruiting
- St. Joseph's Healthcare Intensive Care UnitVerified postcodeHamilton, Canada· Recruiting
- McMaster Children's HospitalVerified postcodeHamilton, Canada· Active not recruiting
- Juravinski HospitalVerified postcodeHamilton, Canada· Recruiting
Common questions
What is 'frailty'?
Frailty means your body is less able to cope with illness and stress, making it harder to recover from being very sick.
What is an 'acute respiratory infection'?
It's a sudden, serious infection that affects your airways and lungs, making it hard to breathe.
Will I need to do anything extra if I take part?
No, you won't need to do anything extra. Researchers will just look at your medical records.
How will this study help people?
It will help doctors and hospitals understand how to better care for people who get very sick with infections like COVID-19, especially those who are frail.
Will my personal details be kept private?
Yes, all your information will be kept confidential and private.
How to find out more
Geoff Strong, PT, MS
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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