Immunogenicity, Safety, Reactogenicity and Persistence of an Investigational Respiratory Syncytial Virus (RSV) Vaccine in Adults Aged 60 Years and Above

To join this study, you must be 60 years old or older when you get your first vaccine shot. You can live on your own in the community or in a care home. It's important that you are generally well enough to take part and can follow the study instructions, as decided by the doctor running the study. If you have longstanding health conditions like diabetes, high blood pressure, or heart disease, you can still participate as long as these conditions are stable and well-managed.

However, there are some reasons why you couldn't join. For example, if you have a condition that weakens your immune system, or if you're taking medicines that suppress your immune system. You also can't take part if you've had a bad allergic reaction to vaccines in the past, have a severe ongoing illness, recurrent seizures, or any condition that significantly affects your memory or understanding.

Also, if you've been in another medical study or taken any experimental (non-approved) medicines or products within the last 30 days, or plan to do so during this study, you wouldn't be able to join. The study team needs to make sure it's safe for you to get the injection and that you can complete all the required visits and tests.

If you decide to take part, you'll receive one injection of the study vaccine. You'll then have several follow-up visits over a period of up to five years. During these visits, the study team will check your health, ask about any side effects you might have had, and take blood samples. The blood samples help them see how your body is responding to the vaccine and how long the protection lasts. You might also be asked to keep a simple diary to record any symptoms or side effects. The exact number of visits and the full duration will be explained to you in detail by the study team, but it could involve regular contact over five years.