Active not recruitingNAINTERVENTIONAL

Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure: Application to the COVID-19 Pandemic

This research is focused on people experiencing serious breathing difficulties, which can happen with COVID-19 or after surgery. We're using a type of scan called a CT scan of the chest to measure how much of the lungs are affected. The goal is to see if these measurements can help doctors understand how severe a patient's illness is and how they might recover. By better understanding these lung changes, we hope to improve care for people with these critical breathing problems. We're looking for a clear link between what we see on the scans and how sick a patient feels.

At a glance

Status

Active not recruiting

Phase

Sponsor

University Hospital, Strasbourg, France

Enrolment target

500

Start

13 Jun 2022

Estimated completion

01 Jun 2027

SARS-CoV-2 Infections Respiratory Failure With Hypoxia

What is this study about?

This study is trying to find a better way to understand how severe lung problems are when someone is very sick, specifically with a severe COVID-19 infection or breathing difficulties after an operation. When someone has trouble breathing due to these conditions, parts of their lungs can become damaged or unable to work properly. Doctors often use CT scans to look at the lungs, but this study wants to see if we can automatically measure the exact amount of lung that is affected.

Imagine your lungs as sponges. If a part of the sponge is full of water, it can't take in air. This study aims to precisely measure how much of your 'lung sponge' is affected. By doing this, the researchers hope to see if this measurement can tell them how serious your condition is. This information could help doctors make quicker and more informed decisions about your care.

The main idea is to see if there's a strong connection between the amount of lung affected on a scan and how sick a patient is. If there is, it could be a valuable tool for doctors to keep track of patients' conditions and guide their treatment, potentially leading to better outcomes for people with serious breathing issues.

Key takeaways

This study aims to improve understanding of severe breathing problems.
It uses CT scans to measure lung changes in COVID-19 and post-surgery patients.
No extra tests or medications are given.
Your participation could help future patients.
You can withdraw at any time without affecting your care.

Who may be eligible?

This study is for adults over 18 years old who are currently staying in a hospital at University Hospitals of Strasbourg or Nancy. You would be considered if doctors suspect you have a COVID-19 infection or if you're having serious breathing problems after an operation.

To join, you or a close family member would need to understand what the study involves and agree to take part by signing a consent form. In very urgent or life-threatening situations, patients might be included first, and consent taken as soon as possible afterwards.

However, some people cannot participate. This includes pregnant women, those who usually need oxygen at home, and individuals who are under legal protection like guardianship.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you currently in a hospital in Strasbourg or Nancy?
Do you have suspected COVID-19 or breathing problems after surgery?
Are you able to understand and sign a consent form (or can your legal representative)?
Are you not pregnant and do not usually use home oxygen?
Are you not under guardianship or court protection?

Answer every question to see your result.

What does participation involve?

Taking part in this study would involve having a standard CT scan of your chest if one is already planned as part of your usual medical care. No extra procedures or medications are given specifically for the study. The study team will then analyse the images from your CT scan and compare them with information about your health condition. This study doesn't require any additional hospital visits or follow-up appointments beyond what is already part of your medical treatment. The total duration of your involvement would be limited to the time your medical data and CT scan images are used for analysis.

Potential risks and benefits

The potential benefit of taking part is that your medical information could help researchers better understand severe lung conditions, potentially leading to improved care for future patients. There are no additional physical risks as you would only be included if you are already having a CT scan as part of your standard medical care. You have the right to withdraw from the study at any time without giving a reason, and this will not affect your medical care.

Locations (2)

Service d'anesthésie réanimation-CHU de Nancy
Verified postcode
Nancy, France
Service d'Anesthésie-Réanimation - CHU Strasbourg
Verified postcode
Strasbourg, France

Common questions

What is a CT scan?

A CT scan is a special type of X-ray that takes detailed pictures of the inside of your body, creating cross-sectional views like slices.

Will I have to pay to be part of this study?

No, you will not have to pay to participate in this study. It will not interfere with your usual medical care or costs.

Will this study affect my treatment?

No, this study will not affect your medical treatment. You will receive the same care you would normally get.

What does 'pulmonary alteration' mean?

It refers to any changes or damage seen in the lungs, like areas that are not working as they should be due to illness.

How long will my information be used?

Your medical information will be used for the duration of the study to help researchers understand lung conditions better.