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Evaluating whether app-based advice on stop-smoking medicines helps people quit smoking

This study aims to understand if advice given through a mobile app about stop-smoking medicines can help more people quit smoking. Many people don't use proven methods to stop smoking, so researchers are exploring if digital recommendations can make a difference. The study will test advice for two medicines: varenicline and cytisine. Participants will be randomly placed into groups – one receiving no specific medicine advice, one advised to consider varenicline, and another advised to consider cytisine. The goal is to see if these digital prompts lead to more people using these medicines and, ultimately, more successful attempts to quit smoking. Learning this could help improve future public health efforts to reduce smoking.

At a glance

Status
Recruiting
Sponsor
University College London
Enrolment target
878
Start
01 Nov 2025
Estimated completion
30 Nov 2026

What is this study about?

Smoking is still the biggest cause of preventable illness and early death in the UK. While there are good treatments and support available, many people who smoke don't use them, which makes it harder to quit for good. This study wants to see if offering advice through a mobile app could encourage more people to use stop-smoking medicines.

The study focuses on two specific medicines. Varenicline is a well-known and effective stop-smoking medicine. Cytisine is another medicine, made from a plant, that works in a similar way and also shows promise for helping people quit, often being a more affordable option.

Mobile apps are becoming very popular for health advice, and this study will explore if using an app to recommend these medicines can increase their use and help more people successfully stop smoking. The information learned from this research could be really important for developing new ways to help people quit smoking across the country.

Key takeaways

  • This study evaluates how app-based advice on stop-smoking medicines affects quitting success.
  • It tests recommendations for varenicline and cytisine, two medicines that help with quitting.
  • Participants will be randomly assigned to receive different advice through an app.
  • The study lasts about seven months and involves answering online questionnaires.
  • Participation helps future public health efforts to reduce smoking.
  • Free access to the 'Smoke Free' app and counselling is provided for support.

Who may be eligible?

To take part in this study, you need to be an adult between 18 and 65 years old, live in the UK, and speak English. You should currently smoke cigarettes and want to quit within the next four weeks. You also need to have recently downloaded and signed up for the 'Smoke Free' app and be willing to answer questions online after two and seven months.

There are also some reasons why you might not be able to join. For example, if you are pregnant or breastfeeding, already taking part in another stop-smoking study, or currently using stop-smoking medication. You also can't join if you’ve used varenicline or cytisine in the last year, or if you have certain health conditions like severe kidney problems, uncontrolled high blood pressure, or a history of seizures. Your doctor can help clarify if these conditions apply to you.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you between 18 and 65 years old?
  2. Do you live in the UK and speak English?
  3. Do you currently smoke cigarettes and want to quit within the next four weeks?
  4. Have you recently downloaded and signed up for the 'Smoke Free' app?
  5. Are you able to fill out online surveys after two and seven months?
  6. Are you NOT pregnant or breastfeeding, or currently taking other stop-smoking medication?
Answer every question to see your result.

What does participation involve?

If you meet the requirements and agree to take part, you'll first answer some questions online about yourself and your smoking habits. Then, a computer will randomly place you into one of three groups. One group will get no specific advice about stop-smoking medicines, another will get advice to consider a medicine called varenicline, and the third group will get advice to consider cytisine. All participants will be encouraged to use an evidence-based stop-smoking app.

You will then be asked to complete two more online questionnaires – one after two months and another after seven months – to tell the researchers about your use of stop-smoking medicines and whether you've managed to quit. The entire study participation, from start to your last questionnaire, will last about seven months.

Potential risks and benefits

Quitting smoking is one of the best things you can do for your health, offering many long-term benefits to your quality of life. By taking part in this study, you'll be helping researchers understand how digital advice on stop-smoking medicines can support people to quit. This information could shape future health programs and help many others. However, when you try to quit smoking, you might experience common withdrawal symptoms like cravings, feeling low, and trouble concentrating. These can be uncomfortable. To help you, the study provides free access to the 'Smoke Free' app, which includes support from a chatbot and professional smoking cessation counsellors available at any time. Remember, you can choose to leave the study at any point without giving a reason.

Locations (1)

  • -
    Approximate
    -, England

Common questions

What is varenicline and cytisine?

These are both medicines designed to help you stop smoking. They work by reducing cravings and withdrawal symptoms.

Do I have to take the medicine if I’m advised to?

No, the study gives recommendations, but whether you decide to use any medicine is always your choice and should be discussed with a healthcare professional.

How long will I be in the study?

Your participation will last for about seven months, from the initial signup to the final questionnaire.

Who is paying for this study?

The study is funded by Cancer Research UK, a leading charity dedicated to beating cancer.

What if I change my mind about participating?

You are free to leave the study at any time without giving a reason, and it will not affect any care you receive.

How to find out more

Dimitra Kale

Always speak to your GP or specialist before deciding to take part in a study.

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