RecruitingNAINTERVENTIONAL

Constitution of a Clinical, Neurophysiological and Biological Cohort for Chronic Sleep Disorders Responsible of Hypersomnolence

This study aims to understand why some people experience excessive daytime sleepiness, known as hypersomnolence. Many things can cause this, from restless legs at night to conditions like narcolepsy. Researchers want to gather detailed information – clinical details, brain activity, and blood samples – from people with long-term sleep disorders. By studying a group of people with these conditions, they hope to learn more about the underlying causes. Understanding these causes is crucial for developing better ways to diagnose and treat excessive sleepiness, which can significantly impact daily life. This research could help improve the lives of many people struggling with these challenging sleep problems.

At a glance

Status

Recruiting

Phase

Sponsor

University Hospital, Montpellier

Enrolment target

5,000

Start

16 Jun 2020

Estimated completion

16 Jun 2033

Somnolence Disorder, Excessive

What is this study about?

Imagine feeling incredibly tired during the day, even after a full night's sleep. This feeling, known as excessive sleepiness or hypersomnolence, can make it hard to focus, work, or enjoy life. Plenty of different things can cause this, from conditions like restless leg syndrome, which disturbs sleep at night, to other problems such as ADHD, which can also make people very sleepy.

More rarely, some people have primary sleepiness, meaning the problem directly comes from their brain’s ability to regulate wakefulness. One well-known example is narcolepsy, where the brain doesn't make enough of a special chemical that helps keep you awake. For other primary sleepiness conditions, like some types of narcolepsy or idiopathic hypersomnia, we don't yet fully understand why they happen. This means it's harder to find the best treatments.

This study aims to create a detailed collection of information (a 'cohort') from people with long-term sleep disorders that cause excessive sleepiness. By collecting information about their symptoms, brain activity, and blood samples, researchers hope to uncover common patterns and differences. This information is a crucial step towards better understanding these complex conditions, which could lead to new and more effective ways to help people who struggle with them.

Key takeaways

This study focuses on understanding long-term excessive daytime sleepiness.
It aims to collect detailed information from people with these conditions.
Information gathered includes symptoms, brain activity, and blood samples.
The goal is to improve diagnosis and treatment for various sleep disorders.
Participants can be children (6+) or adults.
Your participation may help future patients with similar conditions.

Who may be eligible?

To be part of this study, you need to feel excessively sleepy during the day for a long time, and a sleep specialist needs to have identified this. You also need to understand and speak French and be part of the social security system in France. The study is open to both children and adults, starting from age 6.

There are a few reasons why you couldn't join. For example, if you are currently in prison, live in a medical care facility, or are legally considered 'protected' (meaning someone else makes decisions for you). Also, if you don't have social security or simply don't wish to take part, you wouldn't be included. The researchers also wouldn't include you if you have an active infection or inflammation.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Do you experience long-term, excessive daytime sleepiness?
Has a sleep specialist identified this sleepiness?
Are you able to speak and understand French?
Do you have social security coverage?
Are you free from an active infection or inflammation?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, the researchers will collect detailed information about your sleep problems. This will include looking at your medical history, asking you about your symptoms using a scale to measure how severe your sleepiness is, and taking a blood sample. They will also look at 'neurophysiological' information, which involves studying signals from your brain related to sleep and wakefulness. The exact number of visits and the full duration of your participation will depend on the specific type of sleep disorder you have and will be explained in detail before you agree to join.

Potential risks and benefits

Any potential benefits from joining this study are not guaranteed, but your participation will help researchers learn more about chronic sleep disorders, which could lead to better treatments for others in the future. The risks involved are generally low, mainly discomfort from blood draws. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

UH Montpellier
Verified postcode
Montpellier, France· Recruiting

Common questions

What does 'excessive sleepiness' mean?

It means feeling unusually tired and sleepy during the day, even after getting enough sleep at night.

What is the main goal of this study?

The study aims to understand the different causes of long-term excessive sleepiness by collecting detailed information from affected individuals.

Will I receive new treatment in this study?

This study is focused on gathering information and understanding conditions better, not on testing new treatments. Your current treatment will not change.

What is a 'blood sample' used for?

Blood samples help researchers look for specific markers or signs that could be linked to different sleep disorders.

Can children join this study?

Yes, children aged 6 years and older, as well as adults, can take part if they meet the other criteria.

How to find out more

Pôle Recherche et Innovation

depotac@chu-montpellier.fr 0033467330913 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.