RecruitingOBSERVATIONAL

Factors Associated With Mortality in Streptococcal Anginosus Bacteremia

This research is focused on understanding serious infections caused by a group of bacteria known as Streptococcus anginosus (this group includes *S. constellatus*, *S. anginosus*, and *S. intermedius*). These types of infections are known to be severe, often leading to serious health complications and, sadly, can sometimes be fatal. Previous studies have shown that about 15 out of every 100 people with these infections may not survive. The main goal of this study is to carefully look at patient information to discover specific factors or circumstances that might increase someone's risk of dying from these infections. By pinpointing these factors, doctors hope to better understand and potentially improve how these serious conditions are treated in the future.

At a glance

Status

Recruiting

Sponsor

University Hospital, Strasbourg, France

Enrolment target

400

Start

08 Sep 2025

Estimated completion

08 Mar 2027

Streptococcal Infections

What is this study about?

This study is looking into a type of serious infection caused by a group of bacteria called Streptococcus anginosus. This group includes three specific types: *S. constellatus*, *S. anginosus*, and *S. intermedius*. When these bacteria get into the bloodstream, it's called bacteremia, and it can be very dangerous.

Doctors know that these infections can be very severe and often lead to serious health problems or even death. In fact, other studies have shown that around 15 out of every 100 people who get these infections unfortunately don't survive. Because of how serious these infections can be, it's really important for doctors to learn more about them.

The main aim of this research is to try and understand why some people with these infections have a worse outcome, specifically what factors might increase their risk of dying. By carefully looking at information from many patients, researchers hope to identify common patterns or situations. This knowledge could help doctors in the future to better identify patients at higher risk and potentially improve their treatment, ultimately saving lives.

Key takeaways

The study focuses on serious infections caused by Streptococcus anginosus bacteria.
It aims to identify factors increasing the risk of death from these infections.
No new tests or treatments are involved; it's a review of existing patient records.
Findings could help improve understanding and future treatment of these severe infections.
Participation involves your de-identified medical data if you meet criteria and don't opt-out.

Who may be eligible?

This study is looking for information from adult patients who have been treated for a specific type of serious infection. To be included, you must have been at least 18 years old when you were in hospital.

You also need to have been admitted to one of the hospitals taking part in this study sometime between January 1, 2019, and December 31, 2024. During your time in hospital, laboratory tests of your blood must have shown you had the specific bacteria called Streptococcus anginosus (this includes *S. constellatus*, *S. anginosus*, or *S. intermedius*) in your bloodstream.

The only reason you wouldn't be included is if you specifically said you didn't want your information to be part of the study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Were you in a hospital between January 1, 2019, and December 31, 2024?
Did you have a positive blood test for Streptococcus anginosus (including *S. constellatus*, *S. anginosus*, or *S. intermedius*) during your hospital stay?
Have you *not* refused for your medical information to be used for research?

Answer every question to see your result.

What does participation involve?

This study is looking at information already collected from patients’ medical records. You won’t need to attend any extra appointments, take any new medicines, or undergo any additional tests. The researchers will simply be reviewing existing data from your hospital stay if you meet the criteria. There is no direct participation needed from you once you've agreed.

Potential risks and benefits

Because this study only involves reviewing existing medical records, there are no physical risks to you. Your personal information will be kept confidential and used only for research purposes. The potential benefit is that the findings from this study could help doctors better understand and treat serious Streptococcus anginosus infections in the future, potentially improving care for others. You have the right to withdraw your permission for your data to be included at any time, without it affecting your medical care.

Locations (1)

Centre de référence des maladies vectorielles à tiques, CNR Borrelia - CHU de Strasbourg - France
Verified postcode
Strasbourg, France· Recruiting

Common questions

What is Streptococcus anginosus?

It's a type of bacteria that can cause serious infections, especially when it gets into the blood. This group includes *S. constellatus*, *S. anginosus*, and *S. intermedius*.

Why is this study being done?

Researchers want to find out what factors might make people with these infections more likely to have a severe outcome, or even die, so they can improve future treatment.

Do I need to do anything if I'm in this study?

No, you don't need to do anything. This study looks at patient information that has already been collected from hospital records.

Will my personal details be safe?

Yes, your personal information will be kept private and handled carefully according to strict rules to protect your identity.

Can I say no to my information being used?

Yes, if you don't want your medical information to be included in this study, you can refuse, and it won't affect your medical care.

How to find out more

Victor GERBER, MD

victor.gerber@chru-strasbourg.fr 33 3 68 85 37 97 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.