RecruitingNAINTERVENTIONAL

One-Stop manaGemEnT For A Swift Initiation of Endovascular Therapy

This study, called GET-FAST, is investigating a new way to treat certain types of stroke more quickly. When a stroke is caused by a blood clot blocking a large blood vessel in the brain, a procedure called endovascular therapy (EVT) can remove the clot. The faster this is done, the better the patient's chances of recovery. Currently, patients often move between different rooms for scans and treatment, which can cause delays. The 'One-Stop' approach aims to do both the scans and the clot removal in a single room. This study wants to see if this faster method is safe and leads to better long-term recovery for stroke patients compared to the standard approach.

At a glance

Status

Recruiting

Phase

Sponsor

Prof. Dr. Jan Liman

Enrolment target

390

Start

02 Dec 2025

Estimated completion

01 Nov 2028

Stroke Acute Acute Ischemic Stroke AIS Hemorrhagic Stroke, Intracerebral

What is this study about?

When someone has a stroke because a blood vessel in their brain is blocked by a clot (this is called an ischaemic stroke), timing is incredibly important. There's a special procedure called endovascular therapy (EVT) where doctors can remove the clot using a tiny tube, and it's very effective. However, the sooner this treatment happens, the better the chances are for the person to recover well and avoid long-term problems. Even small delays in getting this treatment can have a big impact on a person's recovery, meaning they might not be able to go home or live as independently.

At the moment, when someone arrives at the hospital with suspected stroke, they usually go for scans in one room to confirm the diagnosis and find the clot. If a clot that can be treated with EVT is found, they are then moved to a different room for the procedure. This moving around takes valuable time. Researchers believe that a new way, called 'One-Stop' management, could speed things up. In this new method, both the necessary brain scans and the clot removal procedure would happen in the same room, using special imaging equipment. This could cut down on delays and potentially lead to better results for patients.

This study, called GET-FAST, wants to find out if this 'One-Stop' approach is truly better and safer than the usual way of doing things. Patients will be randomly assigned to either the 'One-Stop' approach or the standard care. This is to make sure the comparison is fair. No matter which group they are in, all patients will receive excellent care according to current medical guidelines. The main thing the study will look at is how well people recover long-term, specifically how independent they are in their daily lives about three months after their stroke. If the 'One-Stop' approach proves to be more effective, it could change how stroke care is delivered, helping more people regain their independence and reducing the need for long-term care.

Key takeaways

This study compares two ways to treat severe strokes caused by blood clots.
The 'One-Stop' method aims to speed up treatment by doing scans and procedures in one room.
Quicker treatment for stroke significantly improves recovery chances.
The study assesses safety and long-term recovery (independence in daily life) at 90 days.
The findings could change how stroke care is delivered, helping more people recover well.

Who may be eligible?

To join this study, you would need to meet certain conditions. You must be experiencing symptoms that suggest you've had a severe acute ischaemic stroke (a stroke caused by a blockage) and your symptoms would be scored as 10 or higher on a common stroke scale (NIHSS).

You must arrive at the hospital within four and a half hours of when you were last known to be well, and you need to be at least 18 years old. Before your stroke, you should have been generally independent in your daily activities, meaning you didn't have significant disability. The hospital must also have a full team of specialists available to perform the urgent stroke treatment.

There are also reasons why you might not be able to join. For example, if you have other serious health problems that might prevent you from getting better or making it difficult to follow up for the study. If your stroke happened while you were already in the hospital, or if there's a strong suspicion that you've had a bleed in the brain (a haemorrhagic stroke), you wouldn't qualify. Also, if you're very unwell and need advanced life support, or if the special treatment room is already in use, you wouldn't be able to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are your stroke symptoms severe?
Did you come to the hospital within 4.5 hours of feeling unwell?
Were you generally independent before your stroke?
Are you at least 18 years old?
Are you currently not in the hospital for other medical reasons when the stroke happened?
Are there no strong signs of a brain bleed?

Answer every question to see your result.

What does participation involve?

If you are eligible and agree to take part, you would be randomly assigned to receive either the new 'One-Stop' management or the usual care approach for your stroke. This decision is made by chance, like flipping a coin. Both approaches involve important scans and procedures to treat your stroke as quickly as possible.

After your initial treatment, you will be monitored as you recover in the hospital. The study will mainly look at your recovery about three months (90 days) after your stroke, focusing on how well you can manage your daily activities. This assessment might involve a visit to the hospital or a phone call with a healthcare professional to understand your progress and independence.

Potential risks and benefits

Participating in this study may offer the potential benefit of receiving your stroke treatment faster, which research suggests can lead to better outcomes and a greater chance of recovery for some stroke patients. However, like any medical procedure, there are always some potential risks associated with stroke treatment and diagnostic scans. The study aims to find out if the 'One-Stop' approach is as safe and effective as the usual care. You will be closely monitored by healthcare professionals throughout your treatment. Remember, your participation is completely voluntary, and you have the right to withdraw from the study at any time without it affecting the quality of your care.

Locations (2)

Klinik für Neurologie, Universitätsklinik der Paracelsus
Verified postcode
Nuremberg, Germany· Recruiting
University Hospital Basel
Verified postcode
Basel, Switzerland· Not yet recruiting

Common questions

What is 'endovascular therapy'?

It's a special procedure to remove a blood clot from your brain using a tiny tube inserted into a blood vessel.

What does 'One-Stop management' mean?

It means you have both your brain scans and the clot removal procedure in the same room, to save time.

Will I still get the best care if I join?

Yes, all patients in the study will receive excellent care based on current medical guidelines, regardless of which group they are in.

How long will the study follow my progress?

The main check-up for the study will be about three months (90 days) after your stroke, to see how you're recovering.

What if I change my mind about participating?

You can leave the study at any time without it affecting your medical care.

How to find out more

Alex Brehm, PhD

alex.brehm@usb.ch +41 61 328 79 48 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.