Phonological Constraints on Language Development in Individuals With Williams Syndrome
This study aims to understand how language develops in children and young people with Williams syndrome. People with Williams syndrome often have very good language skills and sensitive hearing. We want to see if this sensitive hearing plays a special role in how they learn language and use their short-term memory for sounds. To do this, we'll use special brain scans and questionnaires. We'll compare participants with Williams syndrome to those with Down syndrome, who often have different language and memory patterns, and to children who are developing typically. This research could help us better understand how to support language development in children with Williams syndrome.
At a glance
What is this study about?
This study is looking into how children and young people with Williams syndrome develop their language skills. Williams syndrome is a condition that affects development, often leading to some learning difficulties. However, people with Williams syndrome are also known for having surprisingly good language abilities and very sensitive hearing, sometimes called 'hyperacusis'. This study wants to explore the connection between these two things, especially how sensitive hearing might play a key part in their language learning.
The researchers think that the sensitive hearing in people with Williams syndrome might make them rely more on their short-term memory for sounds (called 'phonological short-term memory') when learning language, compared to other children. To understand this better, they will also compare participants with Williams syndrome to those with Down syndrome. Children with Down syndrome often have challenges with their short-term memory for sounds, which can affect their language abilities.
To carry out this research, the study will use some clever methods. This includes special brain assessments that involve measuring brain activity (called EEG-NIRS protocol) and asking participants to complete questionnaires. By comparing how these different groups perform, the researchers hope to gain a much clearer picture of how language develops in Williams syndrome and how their sensitive hearing might be involved.
Key takeaways
- Understanding language development in Williams syndrome.
- Investigating the role of sensitive hearing.
- Comparing groups with Williams syndrome, Down syndrome, and typical development.
- Using safe brain activity measurements (EEG-NIRS).
- No medication involved in the study.
- Participants can withdraw at any time.
Who may be eligible?
This study is looking for children and young people to take part. To be eligible, you need to be between 6 and 17 years old. If you have Williams syndrome or Down syndrome, you'll need to have had a genetic test that confirms your diagnosis.
If you don't have Williams syndrome or Down syndrome, you can also take part if you are between 6 and 17 years old. There's also a group for adults aged between 20 and 60 years old who are developing typically.
However, you won't be able to join the study if you have certain other conditions, like Autism Spectrum Disorder or West syndrome, which is a type of epilepsy. This is because these conditions might affect the study results.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you or your child aged between 6 and 17 years old?
- Do you or your child have a confirmed diagnosis of Williams syndrome or Down syndrome?
- If not, are you or your child a typically developing individual aged 6-17, or an adult aged 20-60?
- Do you or your child NOT have autism or West syndrome?
- Are you willing and able to complete questionnaires?
- Are you able to take part in non-invasive brain assessments?
What does participation involve?
Taking part in this study would involve a few different activities. You would complete some questionnaires, which are sets of questions about various topics. You would also have some special assessments involving an EEG-NIRS protocol. This is a non-invasive way to measure brain activity, similar to putting sensors on your head. These assessments don't involve any medication or needles. The study is designed to be completed over a short period, with no long-term follow-up required after the main assessments.
Potential risks and benefits
Locations (1)
- CHU AmiensVerified postcodeAmiens, France· Recruiting
Common questions
What is Williams syndrome?
Williams syndrome is a genetic condition that affects development, leading to some learning differences, but often good language skills and friendly personalities.
What does 'sensitive hearing' mean?
It means that some sounds might seem much louder or more intense to a person with Williams syndrome than to someone else.
What is 'EEG-NIRS'?
It's a special, gentle way to measure brain activity using sensors that sit on your head. It does not hurt and is completely safe.
Will I have to take any medicine?
No, this study does not involve any medication whatsoever.
How long will I or my child need to take part?
The study involves a single set of planned sessions, rather than ongoing participation over a long period. The researchers will explain the schedule clearly.
How to find out more
Fabrice Wallois, Pr
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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