100% WORKING TREATMENT for my IBS!
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100% WORKING TREATMENT for my IBS!
Hi, I am writing this to try to help everybody that I can because I have been on the same boat as you guys and gone through this living hell for 3 years!!! Short description about my previous case was that I could almost eat nothing, only eat what is normally designated for IBS menu, I was always feeling that I had to go to the Bathroom, I would have IBS-D attacks daily, even taking a lot of Imodium would not work totally, painful bowel cramps, the whole works… I could go on with the list…but you guys already know what are the symptoms from personal experience.
Doctors give this autoimmune disease the name of IBS because they are totally clueless of why this happens, so they just grab all the symptoms and put them in one bag calling it IBS… to me it is just the doctors another way of saying they are clueless but they don´t want to show it to us so they won´t look bad.
Dr. Pimentel who has come up with the theory about SIBO is the cause makes me think that he is correct, this is the only one doctor that had a clue.
Now for the Treatment that I used daily :
From 10 gram to 30 grams of L-Glutamine, to repair the damaged intestinal mucosa and lining. Repairing this will block big food particles from entering the blood stream directly due to the holes in the intestinal lining cause by the bad bacteria.
12 billion Probiotic daily at least, start by using the 50 billion probiotic and then after seeing results you may try to decrease to cheaper probiotics, but don´t go below 10 billion.
Using the SIBO treatment first if desired:
Use Xifaxan ( Rifaximin) antibiotic to wipe out the bad bacteria but this will also wipe out the good bacteria ( check for Dr. Pimentel’s SIBO treatment). While you are doing this, I advise you to take probiotics daily to compensate the bacterial slaughter in the intestines. You can also start L-Glutamine ate the same time to repair the intestinal mucosa and Lining.
After the Xifaxan Treatment, keep on taking the heavy duty 50 billion probiotic daily and glutamine. After getting better, you may try to change the dosages of L-Glutamine and Probiotics and see how you adapt to lower dosages to try to save money.
Since many if not all IBS people are prone to getting E.Coli overgrowth again, you will have to keep on taking L-Glutamine and Probiotics for the rest of your life. I am on this treatment for 1 year and now I eat Pizza, Junk food, Spicy food, drink sodas and Coca-Colas and am totally normal as I was before. I will not say I am cured because it must be an auto-immune disease, but you may keep it in check and be 100% normal by just taking this for the rest of you days ( L-Glutamine and Probiotics).
I have tried previously all know medications for IBS, Antidepressants, anxiolytics , antispasmodics, tried acupuncture, etc. and I was only 30% better, because this medicines do not fix the problem, the just drug your gut to numbness…
This treatment will take around 6 months to reach 100% improvement, but you will notice improvements after 2 months, so be patient.
Good Luck to all and may god help you!
30 likes, 1153 replies
sanchov maurice74943
Posted
Are you not worried of the long term effects of L-glutamine?
I read an article which doesnt suggest long term use of l-glutamine as it accumulates on the brain and also it can cause other many problems (liver toxicity,etc) Her i will copy paste a paragraph:
l -Glutamine accumulation has also been found in Alzheimer’s disease, Huntington’s disease and high levels of brain glutamine have been associated with a worse prognosis in Lou Gehrig’s disease. Likewise, recent studies have shown that high brain glutamine levels increase brain levels of free radicals and impair the ability of brain mitochondria to produce energy. When the brain produces low energy, excitotoxins, such as glutamate, become even more toxic. It has been shown that the reason for glutamine toxicity under these conditions is because it is converted to the excitotoxin--glutamate.
As for Probiotics, here in Russia my doctor also didnt recomend me to take them more than 6 months in such a big quantities. I´ve also read somewhere that it can cause a problem where bacterys can migrate to the bloodstream. I cant remember now the name of this.
Please tell me you opinion, are you not worried about the consecuences of this experiment in the long term? Thank you
PS: About me, i suffer IBS D. i´ve tried the tratment for a month but then i stopped. the main reasons about the long terms effect of lglutamine and also because i couldnt understand if i was improving or lglutamine was just making me constipated. (which was turning my ibs D, in to C)
maurice74943 sanchov
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Glutamine is used to counter some of the side effects of medical treatments. For example, it is used for side effects of cancerchemotherapy including diarrhea, pain and swelling inside the mouth (mucositis), nerve pain (neuropathy), and muscle and joint pains caused by the cancer drug Taxol. Glutamine is also used to protect the immune system and digestive system in people undergoing radiochemotherapy for cancer of the esophagus. Additionally, glutamine is used for improving recovery after bone marrow transplant or bowel surgery, increasing well-being in people who have suffered traumatic injuries, and preventing infections in critically ill people.
Some people use glutamine for digestive system conditions such as stomach ulcers,ulcerative colitis, and Chron's disease. It is also used for depression, moodiness, irritability, anxiety, insomnia, and enhancing exercise performance.
People who have HIV (AIDS) sometimes use glutamine to prevent weight loss (HIVwasting).
Glutamine is also used for attention deficit-hyperactivity disorder (ADHD), a urinary condition called cystinuria, sickle cell anemia, and for alcohol withdrawal support.
Glutamine powder can be ordered through most wholesale drug suppliers. Glutamine for commercial use is made by a fermentation process using bacteria that produce glutamine.
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Special Precautions & Warnings:Children: Glutamine is POSSBILY SAFE when taken by mouth appropriately. Children aged 3 to 18 years should not be given doses that are larger than 0.7 grams per kg of weight daily. Not enough information is known about the safety of higher doses in children.
Pregnancy and breast-feeding: Not enough is known about the use of glutamine during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Cirrhosis: Glutamine could make this condition worse. People with this condition should avoid glutamine supplements.
Severe liver disease with difficulty thinking or confusion (hepatic encephalopathy): Glutamine could make this condition worse. Do not use it.
Monosodium glutamate (MSG) sensitivity (also known as "Chinese restaurant syndrome"): If you are sensitive to MSG, you might also be sensitive to glutamine, because the body converts glutamine to glutamate.
Mania, a mental disorder: Glutamine might cause some mental changes in people with mania. Avoid use.
Seizures: There is some concern that glutamine might increase the likelihood of seizures in some people. Avoid use.
maurice74943 sanchov
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maurice74943 sanchov
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WebMD
Mayoclinic
University of Maryland Medical Center
NCBI
maurice74943 sanchov
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Glutamine is the most abundant free amino acid in the human blood stream and is ‘conditionally essential’ to cells. Its intracellular levels are regulated both by the uptake of extracellular glutamine via specific transport systems and by its intracellular synthesis by glutamine synthetase (GS). Adding to the regulatory complexity, when extracellular glutamine is reduced GS protein levels rise. Unfortunately, this excess GS can be maladaptive. GS overexpression is neurotoxic especially if the cells are in a low-glutamine medium. Similarly, in low glutamine, the levels of multiple stress response proteins are reduced rendering cells hypersensitive to H2O2, zinc salts and DNA damage. These altered responses may have particular relevance to neurodegenerative diseases of aging. GS activity and glutamine levels are lower in the Alzheimer's disease (AD) brain, and a fraction of AD hippocampal neurons have dramatically increased GS levels compared with control subjects. We validated the importance of these observations by showing that raising glutamine levels in the medium protects cultured neuronal cells against the amyloid peptide, Aβ. Further, a 10-day course of dietary glutamine supplementation reduced inflammation-induced neuronal cell cycle activation, tau phosphorylation and ATM-activation in two different mouse models of familial AD while raising the levels of two synaptic proteins, VAMP2 and synaptophysin. Together, our observations suggest that healthy neuronal cells require both intracellular and extracellular glutamine, and that the neuroprotective effects of glutamine supplementation may prove beneficial in the treatment of AD.
maurice74943 sanchov
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Piero G. Antuono, MD,
Jennifer L. Jones, MS,
Yonker Wang, MD, PhD and
Shi-Jiang Li, PhD
maurice74943 sanchov
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Copied text:
In addition to its definitive pathological characteristics, neuritic plaques and neurofibrillary tangles, Alzheimer's disease (AD) brain exhibits regionally variable neuronal loss and synaptic dysfunction that are likely to underlie the symptomatic memory loss and language abnormalities. A number of mechanisms that could give rise to this localized damage have been proposed, amongst which excitotoxicity figures prominently. This is the process, well attested in experimental systems, whereby brain cells are excited to death by the pathophysiological action of the brain's most-abundant excitatory transmitter, glutamate. Glutamate transmission is mediated by a range of ionotropic and metabotropic receptors which, when activated, can lead to depolarization and increased intracellular Ca2+ ion concentration in the cells on which they are located. The action of glutamate is terminated by its removal from these receptor sites by transport into nearby cells, most commonly perisynaptic astrocytes. There it is converted to physiologically inert glutamine and shuttled back to excitatory nerve terminals. Malfunctions in components of the glutamate-glutamine cycle could result in a self-perpetuating neuronal death cascade mediated by glutamate. The approval by the FDA of an ionotropic glutamate receptor antagonist to treat late-stage AD has led to renewed interest in the contribution of altered glutamatergic neurotransmission to disease pathogenesis. This review encompasses those aspects of glutamate-glutamine cycling that are altered in AD.
So from what you see, the issue is glutamate which is not cycled bak into glutamine. Your brain produces glutamine naturally, but some of us may have glutamine deficiency. Good luck
I hope that this may have given you some answers.
claireinc maurice74943
Posted
sanchov maurice74943
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The glutamine is then transported to the neuron and by the enzyme glutaminase, it is converted to glutamate--the potential excitotoxin. I say potential because unless it accumulates outside the brain cell it is harmless.
This is the major source of glutamate within the brain. Excitotoxins are usually amino acids, such as glutamate and aspartate. These special amino acids cause particular brain cells to become excessively excited, to the point they will quickly die. Excitotoxins can also cause a loss of brain synapses and connecting fibers. Food-borne excitotoxins include such additives as MSG, aspartame, hydrolyzed protein and soy protein extract.
In two recent studies it was found that the amount of glutamine in the brain could predict the brain damage seen both in pediatric brain injuries and brain damage secondary to seizures. Adding large amounts of glutamine to the diet increases significantly brain levels of glutamine and, hence, glutamate. Another study found that by adding glutamine to the diet of animals exposed to another powerful excitotoxin called quinolinic acid, brain cell damage was increased significantly. Quinolinic acid is known to accumulate in the brain in most cases of viral brain infection as seen with HIV dementia and viral encephalitis.
Glutamine and Liver Toxicity
Individuals with liver toxicity tend to accumulate ammonia in their blood and brain. Until recently, it was assumed that it was the ammonia that caused liver disease-associated brain injury and that glutamine was protective.
Newer studies indicate that actually it is the glutamine that is causing the brain’s injury. Increasing glutamine in the diet would significantly aggravate this damage.
Free Radicals in the Brain
Glutamine accumulation has also been found in Alzheimer’s disease, Huntington’s disease and high levels of brain glutamine have been associated with a worse prognosis in Lou Gehrig’s disease. Likewise, recent studies have shown that high brain glutamine levels increase brain levels of free radicals and impair the ability of brain mitochondria to produce energy. When the brain produces low energy, excitotoxins, such as glutamate, become even more toxic. It has been shown that the reason for glutamine toxicity under these conditions is because it is converted to the excitotoxin--glutamate.
Glutamine and Multiple Sclerosis
Of particular concern is the finding that people with multiple sclerosis have increased levels of the enzyme glutaminase (the enzyme that converts glutamine into glutamate) in areas of nerve fiber damage. High levels of glutamine in the diet would increase glutamate levels near these injured areas magnifying the damage. It has been shown that excitotoxicity plays a major role in multiple sclerosis by destroying the cells (oligodendrocytes) that produce myelin.
Glutamine and Pregnant Women
Another area of concern would be pregnant women. Glutamine passes through the placenta and may actually be concentrated in the baby’s blood, producing very high levels. Glutamate plays a major role in the development of the baby’s brain. Excess glutamate has been shown to cause significant impairment of brain development in babies and can lead to mental retardation.
When to Use Glutamine
The major use for high-dose glutamine would be to repair gastrointestinal injury. In such cases, I would recommend short-term use only. Those with a history of the following conditions should avoid glutamine, even for short-term use:
Stroke
Neurodegenerative disease
Pregnancy
Malignancy
Recent vaccinations
ADHD
Hypoglycemia
Autism
Multiple sclerosis
Other neurological disorders
Glutamine has recently been shown to produce extreme hypoglycemia, even more so than leucine, which is known to produce fatal hypoglycemia in infants.
The reason Chinese Restaurant Syndrome is not seen with glutamine challenge is that the glutamate receptors in the lungs and esophagus are stimulated by glutamate, not glutamine. The glutamine must be converted first and this occurs primarily in the brain.
The only safe situation for glutamine use is in the vigorous athlete. Glutamine is used as a muscle fuel, so that vigorous exercise will consume most of the glutamine before it can accumulate in the brain. I would still avoid long-term use in high doses. I would caution readers to avoid excess glutamine, especially in the above named conditions and situations.
sanchov maurice74943
Posted
The only safe situation for glutamine use is in the vigorous athlete. Glutamine is used as a muscle fuel, so that vigorous exercise will consume most of the glutamine before it can accumulate in the brain. I would still avoid long-term use in high doses. I would caution readers to avoid excess glutamine, especially in the above named conditions and situations.
Also claireinc said her setpmother got sick from taking probiotics.
I think the long term effects of this things havent been studied. L-glutamine has been studied with persons taking 40g but for how long? 1 month? What about taking this dose for years? it has been some study in those conditions?
maurice74943 sanchov
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"A considerable body of evidence indicates that the activity of glutamine synthetase is decreased in the cerebral cortices of brains affected by Alzheimer's disease. It is difficult to discern the reason for this decrease because it is not known whether the cellular distribution of glutamine synthetase is altered in Alzheimer's disease. Therefore the present study has used immunocytochemistry to compare the cellular distributions of glutamine synthetase in the inferior temporal cortices of six Alzheimer's diseased brains and six age-matched, non-demented brains. Double-label immunocytochemistry has been used to examine whether the distribution of cellular glutamine synthetase is influenced by the distribution of senile plaques. It was found that glutamine synthetase expression in astrocytes is diminished in Alzheimer's disease, particularly in the vicinity of senile plaques. The most striking finding of the present study was that glutamine synthetase was expressed in a subpopulation of pyramidal neurons in all six Alzheimer's diseased brains, whereas glutamine synthetase was not observed in any neurons from control brains. The changed expression of glutamine synthetase may be triggered by toxic agents in senile plaques, a reduced noradrenergic supply to the cerebral cortex, and increased brain ammonia levels. That such dramatic changes occur in the distribution of this critical, and normally stable enzyme, suggests that the glutamate-glutamine cycle is profoundly impaired in Alzheimer's disease. This is significant because impairments of the glutamate-glutamine cycle are known to cause alterations of mood and behaviour, disturbance of sleeping patterns, amnesia, confusion and reduced awareness. Since these behavioural changes are also seen in Alzheimer's disease, it is speculated that they might be attributable to the reduced expression of glutamine synthetase or to impairments of the glutamate-glutamine cycle"
Now what you have copied and sent does not refer to thte amounts of the trials, is only says large amounts. I would consider large amouts to be above the permited 40 grams limit and probably we are taking ten times or more the permited amount because alot of the trials test the extreme dosages above the permited to see the side effects. It is like Zinc, if you go above the permited max dosage, in the long run, it increases the probability of prostate cancer. They did trials with 100 mg a day for 10 years to get to this concusion!!! 100 mg a day is like al least 4 times more the allowed safe dosage!
Once again, I cannot confirm your artical because I cannot find them on any official reliable channels that I usally check.
maurice74943 sanchov
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Also in the start on the treatment, the big dosage may be ok at that time, but it may be also possible that during or after the healing progress, you body might start to show signs that it requires less and you should then decrease the amount because our bowels does not need that much any more because you bowel flora system is being balanced out.
maurice74943 sanchov
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If I was you, I would only use official medical institute sites like the ones I have said previously. I think that I have answerd your question. Good Luck
sanchov maurice74943
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