6 months with no diagnosis. Headaches, muscle spasms, feeling drunk, extreme fatigue. Help!

My husband started having headaches, memory loss and extreme fatigue 6 months ago. It literally started with no trauma or incident. Like just switching a light switch. He took no medication prior to this and was in PERFECT health. He is 40. We have had MRI’s, multiple lumbar punctures, blood work several EEG’s, blood work, MRV and sleep studies. All are negative. They told us migranes and depression? They started him on nortriptilyne (?) and lexapro. It didn’t help. As a matter of fact 2 weeks ago he started with muscle contractions so severe at night that is contorts him into a fetal position and he screams until it releases. This goes on for hours. He began hallucinating last week and the tremors for lack of a better word have now progressed to the day hours as well. He has an episode of urinary incontinence last week and we went to the ER. He goes to Mayo Clinic and he seen every neurologist there. They said he developed serotonin syndrome and took him cold turkey off his meds. We are back at square one but the spasms and tremors have not resolved since the stopping of the medication a week ago. We had another Lumbar puncture yesterday but will have no results for 3 -4 weeks because they send it to New York for testing.  Has ANYONE had anything similar or even heard of anything like this. We are desperate and beyond exhausted beyond belief. He can’t work and has went from perfectly healthy and active and full of life to a shell with possibly 2 days max a week he can even get out of bed from the fatigue alone. Please anything you can lend in advice will be greatly appreciated. 

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