A double-blind, randomized prospective study evaluating topical clobetasol propionate 0.05% versus t
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Hello
having read lots of various reports on the use of both creams have just read about a trial with 58 women half using clobetasol and half using tacrolimus or protopic. The trial was published by the American Academy of Dermatology (07.07.2014) the research was carried out in Montreal in 4 different hospitals.
After 3 months of treatment the clobetasol showed a significantly more effective result than the protopic in terms of the disease itself.
It's really good that there are Doctors out there trying to improve the treatment.
After 3 months of Protopic I had a really bad bladder infection which I have never had before which I am sure was due to the immunsuppressant action of the cream.
1 like, 9 replies
sha1271 marie05247
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Chrisy marie05247
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Morrell1951 marie05247
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hanny32508 marie05247
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Jeepers marie05247
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thanks.
And yes, I agree it is good somebody is doing something, no matter how small, to look at this.
marie05247 Jeepers
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it was an extract printed from the American Dermatology Department but the trial was actually carried out in Canada.If you google on google scholar maybe you can find out more. I know 58 is not a large number but when you think how appantly this disease is so rare I imagine it was difficult to find enough women willing to participate.
Reading through the jargon significant is only used when the benefits greatly outweigh those of the opposing group.
globaby91160 marie05247
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prescribed Clobetasol Propionate. Is that what you all are using? The instructions
state to use on small areas, not large areas. However, I have this over 2/3 of my
trunk. What do you think.
Morrell1951 globaby91160
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What is lichen sclerosus?
Lichen sclerosus is a relatively uncommon condition in which thin white crinkly patches appear on the skin. It can appear anywhere, but is most troublesome in the genital areas.
What are the symptoms of lichen sclerosus?
Many patients have none, but the most common symptom of lichen sclerosus is itch. As a rule the spots on the general skin surface seldom itch much, but those in the genital area do, and can also be sore if the skin breaks down or cracks. In the genital area, the scar-like process can tighten the skin, and this can interfere with sexual intercourse in affected men or women. In men, lichen sclerosus can make the foreskin tight and difficult to retract, and can even partly block the flow of urine.
What does lichen sclerosus look like?
On the main areas of the skin, the spots of lichen sclerosus look like small ivory-coloured slightly raised areas, which can join up to form white patches. Some have tiny yellowish horny plugs within the pale areas. After a while the surface of the spots can look like wrinkled tissue paper. The most common sites are the bends of the wrists, the upper trunk, around the breasts, the neck and armpits.
Most of us are willing to use Clobetasol, which is thousands of times stronger than over-the-counter steroid creams, because we're afraid of our vulva shutting right over the urethra and because having chronic open lesions in a location that constantly gets doused in urine – there's a larger than average chance of developing squamous cell cancer of the vulva. I have psoriasis, sometimes on large areas, and stopped using steroic creams on it over a decade ago, because it usually just goes away when the stress in my life calms down.
Does your dermatologist know you're using clobetasol over large areas? If you were using way too much you might get symptoms like cushings syndrome – puffiness that causes moon face.
Chrisy globaby91160
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