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About hla b27

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rajiv_31599
rajiv_31599

Can any one help me out with the difference in between HLA B27 positive and HLA B27 negative

0 likes, 3 replies

3 Replies

  • peter21326
    peter21326 rajiv_31599

    Posted

    Hi Rajiv,

    ?   HLA-B27 is an antigen found in the blood that is one of the indicators used to diagnose AS.  HLA-B27 correlates with AS which means that people with AS tend to be HLA-B27 positive.  It is not diagnostic by itself since a percentage of people in the general public are HLA-B27 positive and they do not have AS.  However, a much larger percentage of AS  sufferers are HLA-B27 positive so it is one of the things that is checked when someone is being examined for AS.  It is claimed that you can also be HLA-B27 negative and have AS but I'm not 100% sure about that one. 

  • april58811
    april58811 rajiv_31599

    Posted

    Negative As is what I have.  It's harder to diagnose. Because a blood test shows no abnormal inflammatory factors like,  the RA factor being negative, and no inflammation is apparent (swollen knuckles, red puffy ankles; things like that) does that help?

    • april58811
      april58811

      Posted

      Oh right!  What Peter said.... people can be HLA-B27 negative and still b diagnosed with AS.  Nowadays a clinical evaluation is the diagnostic standard for diagnosis because the blood result vary too much.
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