Advice for the final drop with Remeron (3.75 to 0mg)

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Over the past couple years, I have very slowly lowered my Remeron dose from 60mg to 3.75 with a 3.75mg-at-a-time drop each decrease, with anywhere between a few days and several months for each dose decrease. It would usually take 10-14 days to normalize after each decrease and the weird withdrawal symptoms (nausea, anxiety, brain fog, dizziness, malaise) would go away entirely. 

Usually I just split pills, sometimes alternate doses the first few days, and it's not too bad. 

However, going from 7.5 to 3.75 has been particularly difficult. It has been nearly 4 weeks and I still feel the aforementioned symptoms, including some "heavy, raw brain" sensation. The only regrettable part about this process is that I tend to utilize klonopin to help with withdrawal anxiety, and when on less remeron, I tend to have more cravings, so it's sort of an odd cycle. I would, of course, like to quit klonopin entirely as well.

So, to go from 3.75 to 0... Right now, I have 7.5mg tablets and cut them in two to make 3.75. I know some people make an aqueous solution by dissolving pills. I don't want to do that. Does anyone have advice on how to slowly taper off? I have a couple long jobs that involve travel over the next 2 months, but I don't want to wait until after to do this. Should I try taking 3.75 6 days a week for a couple weeks, then 5 days a week for a week, 4 days a week, then begin to alternate, then go every 3 days, then every 4 days, something like that? 

I feel like if I extend my taper too long, I'll be more inclined to THINK I'm withdrawing and take a klonopin or whatever. So I need a good balance.

I would love any advice - thank you so much in advance!

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  • Posted

    Get a pill cutter if you do not already have one.  You should easily be able to break up the 7.5 mg pill into quarters, each quarter being 1.875 mg.  This is the dose I discontinued off of and would recommend that you titer down to 1.875 mg before discontinuing.
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  • Posted

    I would first get stable at 3.75 mg and then drop to 1.875 mg for a couple of weeks. Then I will take a tiny piece after cutting the pull into half (around 1 mg) for another 2 weeks. Now comes the trickiest part. Don't go from 1 mg to 0 but rather start taking 1 mg on alternate days. Then take it in every third day and so on. In this way you can avoid withdrawal symptoms. Don't listen to your doctor if he says you to drop from 3.75 to 0. I hope that helps.

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  • Posted

    Congratulations on getting this far!  I agree with the others!  You've worked hard to get this far so don't blow it now!  Another option is to get an inexpensive milligram jeweler's scale on Amazon to weigh out the last dose.  I'd grind the pills into powder and then weigh out the dose.  Since the pills have binders, they weigh a good bit more than the active dose of med within.  Weigh several whole pills to get an average, and then divide 7.5 mg/pill weight to get the amount of drug per mg of pill weight. Then weigh out the amount of powder needed to get whatever mgs you are wanting to go to.  Dump that in some juice.  That is if you are very sensitive and want to assure you will make it all the way off without too much difficulty.  Alternating days can be a real brain bounce and destabilizing for some, cold turkey one day and then on again the next.  Good luck!

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  • Posted

    Does anyone have advice for a good pill cutter that can cut very small things such as 1/4 of a 7.5mg tablet into 1/8s?
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