Allopurinol and stomach upset.

Posted , 5 users are following.

I found that allopurinol was upsetting my stomach. I tried hiding the tab in a piece of banana - which had some success, but it's difficult to swallow.

More recently I have been swilling a mouthful of water around my mouth and letting the tablet dissolve. I have found this, followed by another glass of water completely stops the stomach issues.

Has anyone else had similar issues with allopurinol?

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12 Replies

  • Posted

    Hi

    Yes i found too much allupurinol was particularly nasty, so I only take 100mg a day. How much have you been prescribed?

    You could always try milk or Actimel as a stomach protector alternatively see your GP and get something like Omeprazole.

    Alternatively try and use something other than Allopurinol, like Febuxostat or Sulfinpyrazone or Benzbromarone

    Thanks

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  • Posted

    I took 4 tablets over 2 days and thought I was going to die. At one point I genuinly believed that my liver had desolved and passed through my backside. Needless to say I stopped taking it. The next attack of gout I had was so bad I tried it again. Two tablets in and I was dying again. I really don't why the medical profession don't use it as laxative ?

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    • Posted

      I do not understand why you began taking allopurinol during a gout attack at all. It is most clear that it should never be used like that; indeed, it will make a gout attack worse! Second allopurinol is *long-term* cleaning out of the acid from the body tissues, not short term fix.Thirdly you should always start allopurinol with lowest dose for safety.

      As for affecting the digestion like that - I think it •may• be kicking in suddenly with a high dose. I found it had slight effect of diarrhea for just a few days after I was on it a week, then again when increased dose, but it quickly settled down.

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    • Posted

      You really need to take colchicine for an attack plus an anti-imflammatory, admittedly if you take too much cochicine it will upset your stomach but it will treat the attack

      As rustygecko says, allopurinol is to reduce the uric acid not to treat an attack

      Thanks

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    • Posted

      Whoops, I was getting mixed up with colchisine. My mistake. However, I was told by my doctor, and the instructions on the medecine bottle clearly say "must be taken with a full glass of water"

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    • Posted

      Of course, and in fact it is sensible to take with 2-3 glasses of water.

      However I found that with water alone and with food it damaged my stomach. However allowing it to dissolve before swallowing (with 2-3 glasses of water), my stomach has recovered.

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    • Posted

      By the way, there was some research which indicated that if colchesine tablets were cut into 2, and taken over a longer period, it gave many less issues.
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  • Posted

    Update: a year+ down the line and I no longer have any issues at all with the allopurinol and just take it as I like, with a glass of water. It’s strange how it became a non issue, as there was a point that it was hurting my stomach so much that I thought I’d have to pack it in. 
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  • Posted

    Hi,this is my ist input on this forum.im hopeless at swallowing any tablets,so I crush them including allopurinol,and take with full glass water,they don't upset my stomach I think because I always take omoprazole.

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