Amarodium

Posted , 4 users are following.

This discussion has been locked due to a period of inactivity. Start a new discussion

i have been on this drug for One month prior to going for a Cardioversion in 2 days, my blood was taken on Monday.I have just had a phone from my doctor,to say my renal function has reduced quite a bit, I have to go to the surgery to get some blood for most checks.i have never had kidney problems before, but this Amarodium has had terrible effects. They may cancel my Cardioversion on Friday, I'm gutted,, I've been so unwell but determined to follow the course, and now this! Dos anybody had kidney problems with this awful drug?....

1 like, 24 replies

Report

24 Replies

Next
  • Posted

    Hi Kathleen, 

    Do you mean Amiodarone ? I wondered because that is the powerful drug used to treat atrial fibrillation . I was put onAmiodarone by the cardiac consultant in January 2015,after previous treatment with Diltiazem had failed and the Cardioversion done in December 2014 had been unsuccessful. I have since changed specialists and now attend Glenfield Hospital , a noted centre for cardiac treatment in the U.K. I am still on Amiodarone plus digoxin and take warfarin daily. A second Cardioversion was initially successful but after a week the atrial fibrillation was back. As far as the side effects of Amiodarone are concerned, the major one to watch out for is damage to your thyroid function. In June a blood test showed that my thyroid was hardly functioning and a visit to an endocrine specialist has confirmed hypothyroidism caused by Amiodarone. I am now on thyroxine and the doses necessary are increasing until they get the balance right. As far as kidney function is concerned, yes. Amiodarone has affected my kidneys and my kidney function readings ( another specialist!) have shown a decline . Whether this is permanent I don't know . Amioderone is a very long lived drug in the system and it is essential you are regularly monitored by your GP and blood tests especially for thyroid levels. Also have regular checks with your optician even if you don't normally wear glasses since it can cause some kind of lesions in the eye. Usually this is only if you are on the drug for years and most doctors see it as highly effective short term treatment. A friend has been on Amiodarone for six years, and refuses to come off it against his doctor's advice. So good luck , work with your consultant but make sure you are well informed. I hope you feel better soon.

    Report
    • Posted

      Appreciate that, , I was all prepared for the Cardioversion, but as I say, I only started Amiodarone 6 weeks ago, and haven't felt well since then, I certainly would be reluctant to use this drug long time. It's strange my bloods were ok last checks, no thyroid or renal problem. I am still hoping the Cardioversion goes as arranged, I'm fed up these frogs jumping out of my chest. Me I add, I have lost quite a lot of weight, I wasn't able to eat for the first two weeks, so all in all, not a drug for me....
      Report
  • Posted

    Hi Kathleen,

    just a point of interest - my specialist told me it takes ten weeks for the Amiodarone to enter your system, so this early in your treatment is probably too soon to make a decision about whether it will suit you long term. You may well settle down and hopefully feel an improvement in the fibrillation as the drug takes effect. Give it time - yes, it is a very powerful drug but the most effective drug on the market for atrial fibrillation. I doubt very much that Amiodarone is responsible for your weight loss since it would barely have entered your system that early in your treatment. Good luck with the Cardioversion though. 

    Report
    • Posted

      It affected my eyes and caused a tremor within three weeks and not long after it caused loss of balance when making small turning movements.
      Report
    • Posted

      Are you are still on Amarodium , or did you change a different. It's a powerful drug. Thanks for that....
      Report
    • Posted

      I have been on it twice. Each time I stopped it after having a cardioversion.

      Google, The Strange History of Amiodarone.

      Report
    • Posted

      If taking Warfarin your dosage should be reduced if later prescribed Amiodarone as it affects your INR.

      This is a paragraph taken from drug warnings on NIH (National Institutes of Health) an agency of the U.S. Department of Health.

      Anticoagulants:

      Potentiation of warfarin-type (CYP2C9 and CYP3A4 substrate) anticoagulant response is almost always seen in patients receiving amiodarone and can result in serious or fatal bleeding. Since the concomitant administration of warfarin with amiodarone increases the prothrombin time by 100% after 3 to 4 days, the dose of the anticoagulant should be reduced by one-third to one-half, and prothrombin times should be monitored closely.

      Clopidogrel, an inactive thienopyridine prodrug, is metabolized in the liver by CYP3A4 to an active metabolite. A potential interaction between clopidogrel and amiodarone resulting in ineffective inhibition of platelet aggregation has been reported.

       

      Report
    • Posted

      Yes, your right, my INR levels rose to 3 .5. Clinic reduced my dose to 1 every day, got it checked yesterday, now at a good 2.5... Thanks fir this.
      Report
    • Posted

      Mine went to 3.9 in a week. I had to research it myself as Assistant Cardiologist had not known nor did the Wafarin nurse at the surgery who was puzzled by my readings for the next three weeks. My GP  did not know and looked at BNF and it does not spell it out. I asked the pharmacist why she did not warn me and she said that all doctors should know. 
      Report
    • Posted

      I have since been diagnosed with optic neuropathy in my left eye but dont know if Amiodarone caused it. It can be caused by a sudden drop in BP when asleep or a surge in blood sugar. 

      A friend had the problem with a large patch of grey skin on his face and neck that went after he stopped taking it. 

      The listed side effects from BNF:

      nausea, vomiting, taste disturbances, raised serum transaminases (may require dose reduction or withdrawal if accompanied by acute liver disorders), jaundice; bradycardia (see Cautions); pulmonary toxicity (including pneumonitis and fibrosis); tremor, sleep disorders; hypothyroidism, hyperthyroidism; reversible corneal microdeposits (sometimes with night glare); phototoxicity, persistent slate-grey skin discoloration (see also notes above), injection-site reactions; less commonly onset or worsening of arrhythmia, conduction disturbances (see Cautions), peripheral neuropathy and myopathy (usually reversible on withdrawal); very rarely chronic liver disease including cirrhosis, sinus arrest, bronchospasm (in patients with severe respiratory failure), ataxia, benign intracranial hypertension, headache, vertigo, epididymo-orchitis, impotence, haemolytic or aplastic anaemia, thrombocytopenia, rash (including exfoliative dermatitis), hypersensitivity including vasculitis, alopecia, impaired vision due to optic neuritis or optic neuropathy (including blindness), anaphylaxis on rapid injection, also hypotension, respiratory distress syndrome, sweating, and hot flushes

      Report
    • Posted

      Hello further on Amarodion, I am just back from hospital, my renal funcion was reduced by 75 per cent, rushed in to hospital, and almost put on dialalises, but they stopped that awful drug and after one week, my renal funcion started to  come up.Ii had to get a kidney biopsy and. have to go to the clinic to be monitored. I can't tell you how bad I have been  since starting this drug, so be. Everybody be very careful, and get monitored all the time,apparently renal problems are not noted on the side effects, but certainly should be watched carefully.

       

      Report
    • Posted

      Hi Kathleen, I have been taking Amiodarone since January and it has caused me major thyroid problems , which is apparently the most common side effect. I am now on increasing levels of thyroxine till they get the balance right. I saw the kidney specialist two days ago, since there has been a decline in my kidney function over the last two years. The specialist did not blame the amioderone but said it was linked with the atrial fibrillation and the oxygen not being circulated properly. I was actually pleased to discover that my kidney function has improved significantly since my last test six months ago , which the specialist thought was due to the amioderone controlling the fibrillation. I think this drug should not be demonised. All strong medication has side effects and presumably when a consultant recommends this drug he does so for good reason. The two cardiologists who have treated me have both agreed that I need Amiodarone since it is the best most effective drug available for Atrial fibrillation. A friend who has had major heart surgery refused categorically to take this drug after she read lots of negatives on Google. Her consultant begged her to take it in order to prolong her life but she would not be persuaded. She is currently in a hospice with days to live. And now she has started Amiodarone ! 
      Report
    • Posted

      This has been really terrible for you. I do hope that your kidney function goes back to normal soon. In some ways it is fortunate that you had an immediate reaction rather than it slowly killing your kidneys.

      The effects of this drug are so long term that often people have been taken off it and their later symptoms are not associated with it.

      Did you have your cardioversion?

      Report
    • Posted

      It is supposed to be prescribed for life threatening arrythmias but they are dished out like smarties when other drugs would suffice.

      Why is a heart patient in a hospice when cardiology units are the best equipped even at this late stage. What is her earlier cardiac history. Was her AF like mine as a result of her heart surgery?

       

      Report
    • Posted

      No Derek, they had to cancel because of my renal funcion being so low. I will probably get a clinic appointment  from Cardiologist to go where I go now. I am so glad my kidneys are recovering. I was put on Bisoprolol low dose, so far my pulse is sitting at around 70, and no frogs in my chest !!!! I didn't want to go down the road of beta blocker, but here I am!!! .....

       

      Report
    • Posted

      I had a lot of problems with bisoprolol as well as most others.

      I had a kidney MRI last November and it was OK. I have a kidney cyst that is now 53mm that I am told is harmless but have pain in that area and will be having a Ultrasound scan next month. 

      Report

Join this discussion or start a new one?

New discussion

Report as inappropriate

Thanks for your help!

We want the forums to be a useful resource for our users but it is important to remember that the forums are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the forums is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.

newnav-down newnav-up