Amitriptyline and Swollen Eyes

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Hi. I've been prescribed 25mg Amitriptyline for nerve pain following side effects of very red, sore, swollen eyes whilst taking Gabapentin and Pregabalin. Unfortunately I'm now experiencing the same on Amitriptyline. I see that a lot of people have advised to persevere with it in relation to other side effects and wonder if the swollen eyes will also stop as time goes on. Has anyone experienced this side effect at all?

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  • Posted

    Hi Carolyn

    ?Unfortunatey Amitriptyline can and does affect the eyes. I was unfortunate enough to develop within 36 hours a very rare form of Glaucoma named Sudden Onset Acute Angled Closure Glaucoma and was admitted as an emergency to York Hospital where Specialist Registrars battlled to save my sight. I had emergency laser treatment and apart from some leftover probems I still have sight. Please be careful if you are sufferng side effects with your eyes, it is not worth risking your precious sight. As I said, my case was extremely rare but Amitriptylline definitely triggered it. Talk with your GP and bring your concerns into the open, then take the advice given. If you don't mind me asking, how long were you on Gabapenten and Pregabalin? These drugs are very difficult to just suddenly stop taking and I wondered if you had any problems. Did the eye problems stop before you started Amitrip and then start again or were they present throughout? If so, it may be the effects of the other two drugs carried over if you see what I mean.

    ?I do hope you get this sorted and wish you well

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    • Posted

      Hi Elizabeth. My eyes started swellibg with Gabapentin withinnaround of 2 weeks of taking it. I stopped taking it Christmas Day and contacted the doctor after the Christmas holiday. He changed me to 25mg Pregabalin for 1 week to see if I reacted. I didn't but the dosage was too low and he changed it to 75mg morning and night. I reacted within 1 days dose. So he changed me to Amitriptyline- again low dose 25mg at night but I've reacted again. I'm obviously sensitive to this side affect and just think I'll have to put up with the pain which I'm not looking forward to

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    • Posted

      Oh dear, it does seem that your eyes react to this type of medication. I unfortunately am taking Pregabalin for neuorpathic sciatic pain but I cannot take the awful side effects so plan to taper off them soon. I too may have to live with dreadful nerve pain but my Doctor has started me on morphine patches, lowest dose, but I can have higher dose ones if this one gives me no relief. Other than that there is Co-Codomol which you can take alongside the morphine patches. Side effects of morphine I have yet to discover but it seemed the most sensible route to go. Worth thinking about for you even if the combination doesn't take all the pain away it certainly takes the edge off mine allowing me to get daily chores done albeit not as well as before. I do hope you have a good GP who will alllow you to explore other routes to pain relief and hope you feel better soon

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    • Posted

      Hi Elizabeth

      Co-codamol doesn't work so will see what the doctor comes up with. I know some of the damage - arthritis of the spine and no cartilage left in between the discs in my neck. Waiting for a MRI to know the extent of the damage. Hope all works out for you. What we go through....

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    • Posted

      ? wish you well on your pain relief journey Carolyne. Co-Codomol didn't work on my arthritis (inflammatory and psioratic) so I swapped over to Dihydracodeine which does take the edge of it and hoping with morphine patch alongside it will help. It's the sciatic trapped nerves that overwhelm me 24/7 - my lower 3 vertabra have disintegrated and crumbled trapping these nerves very badly. I see the Bone Doctor in March to see if he can help me. As you rightly say, the things we go through!! Keep in touch and let me know how you get on and the result of your MRI scan.

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