Antacid exacerbates RLS

Posted , 6 users are following.

I'd like to share my personal experiences with antacid, PPIs, or histamine 2 blockers.  Everytime I take either Omeprazole, or Zantac, or Pepcid, my RLS acts up like crazy even after only 2 to 3 days of taking them.  I have consulted with a RLS specialist about the effects of antacid on RLS who adamantly denied the effects on RLS.  Therefore I have searched on line and tried to find out if there is any association between them.  According to a prestigious and cridible article, there is no robust direct evidence to support any association of PPIS and RLS. it says there is an indirect evidence, because PPIs would alter the PH in the duodenum and may interfere with

iron absortion in certain patients.  According to my personal experiences I don't agree with this theory.  The reason being 1, I am being fed via a J-tube, it means all my nutrition would bypass the stomach and go directly to my small interstine. 2.  SInce my nutrition go to my small interstine, I would not experience iron deficiency associated with taking food the normal way, by mouth and go to my stomach. So, I'd like to know if anyone has similar experiences with antacid or I am just a very weird, unique person.  Thanks.

 

1 like, 8 replies

Report / Delete

8 Replies

  • Posted

    Hi Zu, those antacids totally make my legs/body go crazy.  It just shows how one little pill can alter the course of RLS.  The same is probably true for things the other way.  A change in diet, some iron, or magnesium and we can reduce RLS symptoms.

    As you know those types of antacids work via the histamine pathway.  And their effect starts with the first pill so I don't necessarily think it is because of iron malabsorption.  But I do think that the histamine pathway is part of the cascade of events/chemicals in the brain and thus I believe those antacids directly effect the release of dopamine.

    Report / Delete Reply
  • Posted

    I take Tums at night for slight hearburn.  will try not taking it to see it that helps.
    Report / Delete Reply
    • Posted

      No tums should not hurt you.  It's the H2 blockers like Zantac that are the problem.  Try taking iron bisglycinate (25mg) before bed on an empty stomach away from all other supplements and medications.

      Report / Delete Reply
    • Posted

      Hi Dusty,

      I was just wondering if you ever determined a correlation between the Tums and RLS.  I rarely experience RLS, but last night I had a really bad episode.  When I was searching for clues for anything I had done differently, I remembered taking 4 Ultra strength Tums during the day.  I never take these so it kind of stood out to me.

      Thanks in advance for  info about your experience.

      Jean

      Report / Delete Reply
  • Posted

    Hi,

    I found this thread via google search for any correlation between tums and restless legs. I know this is from a year ago but I would like to share my experience. I’m currently 32 weeks pregnant and started having some restless leg sensations here and there. But I noticed that when I take tums for occasional heartburn, I get restless legs within an hour or two after. Come to think of it, I’ve noticed the same thing in previous pregnancy as well. Out of curiosity, I googled to see if anyone else had experienced the same thing or whether tums/ antacids cause or have a reaction that produces restless legs. Side note: I only have restless legs and heartburn when I’m pregnant. 

    Report / Delete Reply
  • Posted

    Omeprazole is a no-no for me. I have heartburn and indigestion often but can no longer use Omeprazole as it is an RLS trigger for me. I find when I have heartburn it often coincides with worsened RLS but it may be due to a heavy meal, eating late, spicy food etc or perhaps taking antacids? Need to pay more attention!
    Report / Delete Reply
  • Posted

    Hi i take zantac regulary if i take it in the morning its not too bad i just get like a restless feeling but if i take it late afternoon i can guarentee I'm vawake all night with RL S I'm up at present writing this as can't sleep with it my mum used to get it too and took zantac

    Report / Delete Reply

Join this discussion or start a new one?

New discussion Reply

Report or request deletion

Thanks for your help!

We want the forums to be a useful resource for our users but it is important to remember that the forums are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the forums is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.

newnav-down newnav-up