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Mirtazapine appeared to 'poop out' on me around 3 years into my therapy with it. I had been diagnosed with severe depression before going on it I scored almost the maximum on the test. My symptoms were fatigue, nervousness, jumpiness, anxiety, severe depression, insomnia, anorexia, weight loss, itching, migraine, heart palpitations and IBS. The GP tried me on several antidepressants, none of which worked until I tried mirtazapine and it was just amazing. I felt better within days. All of my symptoms disappeared. It was a miracle drug which gave me my life back. Then when it suddenly pooped out my symptoms all came back and I was also diagnosed with chronic kidney disease stage 3. I decided to come off it and tapered off really gradually with very few WD symptoms. I had a period of feeling good again and then wham! All my symptoms returned. I thought I had delayed WD but something in me told me it was a physical illness.
Long story short, we have a new GP and he's sharp as a pin. Did many tests on me and I was diagnosed with hyperthyroidism. My sympptoms have become gradually worse and I am pretty ill right now, especially with heart related symptoms. I have been put on carbimazole and propranolol.
The purpose of this post is to urge all of you with depression to get your thyroid checked. It can be very dangerous if it is left untreated and is very often misdiagnosed as depression because it shares most of the same symptoms. Both under and overactive thyroid cause depression. Drugs such as mirtazapine can mask the symptoms. I reckon mirt masked my hyperthyroidism until it became so severe that it just couldn't mask it anymore. That's why it appeared to poop out after working so well for so long.
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