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Antibiotics and PMR

Posted , 11 users are following.

rocketman42
rocketman42

I have had PMR for about 2 years and I'm currently taking 11mg of methylprednisolone. Have had problems in the past getting below 10mg.

I unfortunately ran into a dental infection last week and was placed on Amoxicillin.

During this time I have found that my PMR symptoms have improved and I'm feeling significantly better.

Wondering if this is a coincidence or if there is a direct cause and affect relationship going on?

Has anyone else ever experienced this and does anyone know if there is anything in the literature that addresses this affect? 

0 likes, 6 replies

6 Replies

  • Anhaga
    Anhaga rocketman42

    Posted

    It's possible that the tooth infection was contributing to your overall inflammation load.  Others have found that although clearing up a dental problem doesn't "cure" PMR it seems to make a lower dose easier to attain and they feel generally better.

  • constance.de
    constance.de rocketman42

    Posted

    I had a really bad attack of bronchitis whilst in hospital in March.  They “dripped” antibiotics in night and day for 5 days.  During that time I had far less PMR pain.  But, as I was lying in bed most of the time (high fever) it’s perhaps not surprising.😏

  • margaret22251
    margaret22251 rocketman42

    Posted

    Hi I am on 10mg pred and mtxt.

    i have had to go on Amoxicillian and something else for a kidney infection, but it has never improved pmr pain for me.

    but someone more experienced than me will come along and tell you more.

  • EileenH
    EileenH rocketman42

    Posted

    A lot of people have commented that they feel better while on abx. The effect doesn't last though.

    My husband has a colleague whose wife had what appeared to be PMR. She reacted badly to pred (I have no idea what dose, I suspect probably higher than was needed but I don't know). He persuaded her doctors in Hungary to try long term antibiotics which they had noted had a similar effect to yours - again, no idea what or what dose. It apparently worked to get her PMR into remission - or to cure whatever was causing it.  I, on the other hand, have never had any relief from antibiotics at all.

    As a mechanism - antibiotics do have an antiinflammatory effect. And as Anhaga says - maybe the dental infection was contributing to the way you felt.

    • rocketman42
      rocketman42 EileenH

      Posted

      The tooth has been a chronic problem for the past 10 years with intermittent acute episodes with the latest being this past week thus the Ab.   I’m having the tooth removed today so it will be interesting to see if my PMR symptoms improve since theoretically the source of the infection ( inflammation ) will be gone.  
  • amkoffee
    amkoffee rocketman42

    Posted

    I just finished a 2 week course of amoxicillin and although it did clear up my chest infection it didn't help my PMR. I guess you are one of the few lucky ones.

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