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Anyone heard this in LP results?

Posted , 3 users are following.

alison1983
alison1983

I recently had a lumbar puncture and evoked potentials test.  I asked my GP for a copy of my results letter as he couldnt explain anything in it.

"Oligoclonal bands detected in CSF only, and not in serum.  This is indicative of local synthesis of immuniglobulin within CNS."

Evoked potentials...

"The evoked responses displayed artefact disturbed recordings, however reasonably well defined P100 responses bilaterally.  The latency of this is markedly delayed, i.e. there is significant slowing of conduction in both visual pathways."

Anyone know what this means.  I have yet to be given diagnosis.

0 likes, 3 replies

3 Replies

  • GloShivWeb
    GloShivWeb alison1983

    Posted

    I am a Medical Technologist I will look it up and try to explain
  • alison1983
    alison1983

    Posted

    Thank you very much GloShivWeb
  • GloShivWeb
    GloShivWeb alison1983

    Posted

    Sorry Allison 

    It has been very busy at work. I finally got the time to look this up for you. It's kind of long but I feel its easy to understand. If you don't understand please contact me again.

    Normally, very little protein is found in CSF because proteins are large molecules that do not cross the blood-brain barrier. Normally, the proportion of albumin to globulin is higher in CSF than in blood plasma because albumin is smaller than globulin and can pass more easily through the blood-brain barrier. Such diseases as meningitis, encephalitis, and myelitis can alter the permeability of the blood-brain barrier, allowing protein to leak into the CSF. 

    CSF protein electrophoresis is very important in the diagnosis of CNS diseases. Patients with Multiple Sclerosis, neurosyphilis or other immunogenic degenerative central neurologic diseases have elevated immunoglobulins in their CSF. The detection of oligo-clonal gamma globulin bands is highly suggestive of inflammatory and autoimmune diseases of the CNS, especially multiple sclerosis (MS), Myelin-basic protein, a component of myelin (a substance that surrounds normal nerve tissue) may be elevated when demyelinating diseases (e.g., MS and amyotrophic lateral sclerosis) occur.

    Allison I am working on an article on MS in the future but it is not complete yet. But there is lots of information at the MS Society https://www.mssociety.org.uk/

    Let me know if you need more help with this.

     

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