Skip to content

Anyone using Imuran as a supplement to reducing prednisone? What have you found for side effects

what is your experience with it?  Is it harmful in the long run?  how do you counter the fatigue?

7 Replies

  • nancy02150

    The drug you mentioned is used for treating a number of things. 

    In your case could it be rheumatoid arthritis ?

  • nancy02150

    Having never heard of this drug I Googled it and it is an immunosuppressant too. I don't know why you would be given this and prednisone but looking forward to reading other people's posts on this medication. I wonder how it differs from prednisone.

  • nancy02150

    The thinking behind using azathioprine and other DMARDs such as leflunomide or methotrexate is that they add to the immunosuppressive effect and allow the same effect to be achieved with a lower dose of pred. There is little study evidence that this is achieved reliably but there are rheumies who claim they have worked well for them - at least, each rheumy seems to have their favoured drug to use in this way. 

    I suspect that often when they work it is because it wasn't PMR in the first place but some form of inflammatory arthritis - where they would be the first line choice anyway. About 1 in 6 patients with an initial diagnosis of PMR go on to be given a different diagnosis at some later stage.

    In the most recent recommendations for the treatment of PMR

    they discuss this in Recommendation 7. They feel methotrexate is worth a try on an individual basis and IN DISCUSSION WITH THE PATIENT. No other DMARDs get a mention, including azathioprine/Imuran. I have tried methotrexate - after 4 weeks I felt worse than I ever did with untreated PMR! The fatigue was overwhelming - the other side effects were unpleasant but none really bad enough to say no - but all together they were. I did it to humour my new rheumy - but I can't live like that even if it did get me to a few mg lower. I think it is perhaps worth a try if you don't develop any side effects and, to be fair, many people take it perfectly happily. But, nevertheless, about a third of patients stop mtx because of the side effects. Perhaps the same should apply to azathioprine - but it seems less successful.

  • nancy02150

    In 2015 I was prescribed Azathioprine 50mgms tablet daily.  This was to be increased to 1 and a half tablets after 28 days to treat my PMR alongside the prednisolone I was taking at that time.  On the 11th day I developed a very high temperature, vomiting , diarrhoea and confusion  - advised to stop Azathiorine immediately and a couple of days later I was ok.  6 weeks later it was decided to trial me again in case I had a viral infection at the time of the first trial. After a few days into the trial the same symptoms recurred - end of trial.  I am currently on 5mgms prednisolone daily.  


Report as inappropriate

Thanks for your help!

We want the forums to be a useful resource for our users but it is important to remember that the forums are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the forums is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.