Brand verses generic ?
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I am still having problems with sleepiness. I have been taking mirtazapine (generic) for seven months now. I have been told by a doctor that there is no difference in the brand (Zispin) and the generic (mirtazapine) which most of us take. I am sure that there is a difference between different generics and I am sure that I am sensitive to them. I wonder if anyone else has this sensitivity to the same drug but different generics. I am quite keen to reduce one of the other drugs that I take prothiaden and increase the mirtazapine but I need to be sure of its side effects first. If I would do better on the brand Zispin then I shall ask for that. I have only ever been offered a generic and never the brand I guess because the generic is cheaper.
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I have never been given zispen, but have tried 2 different generic versions and I can certainly tell the difference, even took one lot back to the chemist and asked for them to swop them for the ones I had originally been on but was told they are exactly the same. But yes I certainly feel better on one kind than the other.
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Pooh_bear
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Bacause I have an encyclopedic knowledge of useless info in my head, I can answer some of the general answers here. I worked in the pharma industry making tablets for about 1 year and am a chemist by trade (atmospheric, not pharma, but subject was part of many courses I'd taken).
I too have noticed a difference in how some drugs interact and my own case is Co-Codamol Vs. Solphadol (both contain the same amount of active ingredients). Basically all drugs consist of the active ingrediant(s) and the rest (excipients). Excipients are added for many reasons (e.g. making a low-dose pill into something convenient to swallow; dye colourant, etc). My theory is that the makeup of the excipient is the reason why most people notice a difference when switching brands.
One of the most important test for a drug in production is a dissolution test whereby a sample of the batch of tablets is dissolved in body-temperature water to mimic the action of dissolution in the stomach. Excipients called disolving agents (e.g. lactose, maize starch, sodium starch glycolate etc) are key to this timing. So if a generic has got a slower releasing binding agent (as is usual, that's how they can make them cheaper), there is ultimately a lower blood-plasma concentration of the active ingrediant. If the drug is designed correctly, it will have a optimum point in the GI system where it should be disolved to yield maximum effect in patients (called the 'Therapeutic Window'). Generics can sometimes miss out on this window (as a disgusting example one of my controlled-release drugs is often whole in my poo the next day; whilst it shouldn't be!).
Hope this is understandable and that if you've got an issue with a generic I'd suggest you talk to your pharmacist about it's dissolution agent.
Silent..