Can Beta Blockers cause Autonomic Dysfunction?

Posted , 15 users are following.

I was perfectly fit and well until end of last December when they put me on a small dosage of the Beta Blocker Bisoprolol due to ectopic heart beats that developed into Ventricular Tachycardia.

As soon as I started taking them, I described myself as being turned into an old man overnight who could no longer feel my lungs working, like a drunk zombie.

When they found me in a state of near collapse at work with a heart beat after oxygen given, of only 42bpm, they declared I was allergic to beta blockers and I have not taken any since March.

The symptoms however remain to this day and all the doctors, GPs, cardiologists, they refuse to even consider that beta blockers are to blame and so attribute my illness to anxiety from an abused childhood.

I do not feel anxious, I have worked for over 40 years with no symptoms of anxiety until the day they put me on beta blockers which seems to be a bit too much of a co-incidence.

Beta blockers however, they block adrenaline receptors in your Autonomic Nervous System, so I have symptoms of disruption to my ANS following taking medicine that not only disrupts your ANS, but that I reacted badly too. This seems rather more a logical reason for my current sickness, but how can I get anybody to even investigate the possibility?, they have all told each other it is anxiety so of course I cannot get past this presupposition.

I have found a detailed description of Autonomic Dysfunction on the Dantest site, they make medical machinery for the study of such. they list causes of Autonomic Neuropathy including medications that include " Drugs that decrease sympathetic activity (sympatholytics): alpha and beta blockers (i.e. metoprolol), barbiturates, anesthetics", but of course I would simply be told to not believe things I read on the web!

In addition, I possibly have a genetic predisposition to this as I have a Maternal cousin with Fibroid-Mialgia and Paternal half-sister with the same symptoms as POTs.

My current symptoms are ectopic beats and palpitations that occur mainly later in the day when I get tired, and after eating that can get so that every other heart beat is an ectopic.

My heart rate is around 30bpm faster than it used to be in any given situation, it also seems to fluctuate wildly doing the same activity.

Horrendous heartburn and the feeling that my esophagus is closed so that if I eat half what I used to, it feels painful, I feel full up with just a few mouthfuls.

My sense of hunger and thirst are diminished, a few weeks back I did a little experiment, I didn't eat a single thing for 42 hours and still didn't feel hungry.  

Breathlessness and the feeling my lungs do not work automatically. When I talk to people now I sometimes forget to breath and they suddenly see me stop to take a gasp, when I fall asleep I keep waking with a gasp as I forget to breath.

My cardiologist did arrange a lung function test, but this only measured the capacity of my lungs, it didn't measure the lungs gaseous diffusion efficiency.

I had noticed when in hospital that the machine kept beeping because even awake, my blood oxygen level would fall to 87%

So I bought my own Oximeter, sometimes it can be as high as 98%, so there is obviously nothing mechanically wrong with my lungs, but generally it is in the low 90s when relaxing, when I go to sleep however, it spends half the night at 85%

I read that the ANS detects a low oxygen level in your blood and automatically adjusts your breathing.

An eighth month old cough. They tried me on a different beta blocker, Salotolol, this right away put me into a coughing frenzy so my GP told me to come off which I did, the bad cough went right away, but I have been left with a permanent dry cough that gets worst when I talk of when I have a shower it gets so I am nearly vomiting. 

Exhaustion, utter exhaustion, I had to go to work to see O/H and chatted to a few friends, so I was there for about four hours, then I had a meal there, that must have used the last of my energy as I could muster up just enough energy to draw breath, had to sit down for a couple of hours before I could get up again. All my symptoms are worst when tired, so I have to spend the following day in bed after doing anything as strenuous as going out. I don't even have the mental energy to pass my time with computer games, often it is hard to force myself to do anything more than just sit and look at the floor.

Brain Fog, when I get exhausted my speech becomes slurred, I cannot walk straight and feel drunk, I have this all the time to a lesser extent.

Tingling in my feet, often when lying in my bed this expands to a quivering I feel throughout my whole body.

I now find myself waking in the night in order to urinate, as much as four times, full loads not a prostate trouble load.

I do not have the POTs symptom, I measured my heart rate as only going up by 20bpm when standing from lying down.


2 likes, 41 replies

41 Replies

  • Posted

    Hello Peter01729,

    Thanks for sharing your situation. I found it very interesting. I too, quickly developed a list of first-ever symptoms after taking Methyldopa, for extreme, uncontrollable blood pressure surges. I’ve also taken metoprolol in the past and am currently taking Bisoprolol every morning. However, my new symptoms didn’t begin until I took Methyldopa. The symptoms were extreme and debilitating. They hit me with a bang, out of the blue, for no other reason at all, except that I had been placed on Methyldopa by a well-known physician at Vanderbilt. I had been faithfully taking the medication several times a day, just as he prescribed. Each day I took 125 mg every “two” hours and “750” mg at bedtime. Not long afterwards, the symptoms began and with a vengeance. Most obvious was repetitive, involuntary, uncontrollable, fast, and ballistic limb jerking  (arms and legs) that would last for hours. Most times, my arms would ballistically jerk inwardly, crossing over each other, while both feet banged (outward to inward) together at the same time. I could not make them stop. This would last for hours nonstop. It would continue even if I tried to stand up. My head would also bob up and downward and my feet became entangled when I tried to take a step. There was no coordination. I could not walk. It was a huge struggle to try to put one foot forward. Sometimes the entanglement of my feet caused my right leg/foot to involuntarily cross completely over my left leg/foot. I had NO control over any of these movements! It was so severe that I could not function. This lasted for several years! Today, I have jerking of my arms, but not as much.  Yes, I also experienced severe brain fog and still do. I especially experienced it the most when I stood up from a sitting and/or lying position, but at times it would just happen, even when sitting. It was if my brain instantly stopped. I can’t think -to think.  During the brain fog, I can’t think of anything. I don’t know anything. I can hear but can’t respond. I innately learned that I feel better if I place my head downward on a countertop or furniture, to let blood go back to my head, about 3-4 minutes, so that my brain would begin to work again. This was/is how I cope with the brain fog. If I didn’t lean (head downward) on top of countertops and furniture, then I would fall, as I can not talk, walk or coordinate during the brain fog.  This happens countless times each day. I also have extreme spells of slurred, unintelligible speech. It is worst when I’m tired and stressed. I can hear myself speak with no clarity, and I know what I want to say, but I have no control over what I’m trying to say. As you mentioned, exhaustion is a very common symptom. Sometimes, I’m so exhausted that I feel I’m going to collapse. Many times, both my arms drop into my lap from exhaustion. I’ve not measured my oxygen level but I wouldn’t be surprised if that explains the extreme feeling of weakness and exhaustion. I’ll have to measure it. Yes, I’ve had tingling in my feet and even a very uncomfortable sensation  best described as an electrical charge that flashes throughout my entire body, after I lay down. It is very strange and uncomfortable, like I’ve touched a live wire. There are times, my legs feel so uncomfortable/restless that I have to stand up to ease the odd feeling in them. I also have 24/7 nonstop shrill ringing tinnitus and even occasional  “electrical base-thumping” sounds mixed in. I’m 58 now and have never been an anxious person. I have been battling these symptoms since I began the Methyldopa in 2012.  When my older sister came to visit me and saw how sick I was while trying to raise my young son, she stayed with me to help me. My sister video tapped me with the limb jerking and inability to walk or talk and emailed it to the doctor who had prescribed the Methyldopa to me. With no response, we also called the doctor and my sister described the severity of  my limb jerking, brain fog, etc. The doctor immediately denied Methyldopa could cause such and told me “I needed to see a different kind of doctor” and that he “could not see me any longer”. That was the last I heard of him.  He dropped me like a hot potato. This was a doctor that I had spent many years, driving several hours one-way, to see, while placing my faith in him that he would help me with my severe and extreme blood pressure surges. Dealing with my wild blood pressure was hard enough, but compounding that with all the additional new symptoms became more than I could bear. Like you, I have been told the symptoms are a result of anxiety and childhood abuse-even if I can’t recall such!  I don’t believe it for a minute! I feel there has been damage to my nervous system.  Did they give you a name for the condition that was caused by childhood abuse? What is the link to where you read certain medications can affect the ANS?  Did you experience any significant medical concern prior to your symptoms? Which doctor(s) told you it was due to anxiety from childhood abuse? Please keep in touch. Thanks!

    • Posted

      Hi, your symptoms almost sound like Parkinsons which I understand is a disorder that is related. The needing to lie down bit sounds like POTs.

      Prior to my ANS symptoms, I felt perfectly well apart from the occasional ectopic beats that developed into Ventricular Tachycardia, I wasnt at all concerned about my health, I had the ectopic beats for a year before I even bothered seeing a GP about them in 2014.

      It was my cardiologist who said it was from anxiety, he decided to share this unfounded opinion with my GPs and with work so now I am totally disregarded.

      If I post the link, you wont get this message for a few days whilst the site checks it out, so, in a Google search engine type :- Autonomic system overview-dan test

      The first link should be along the lines of Dantest dtr ans overview.

  • Posted

    Hi Peter,

    ?I've moved over to your thread.

    ?It looks as though we've been doing the same things particularly after suggesting to the medical profession that a prescribed medication has caused an adverse reaction.

    ?I proved to myself that the right thing to do was to withdraw from two different treatments due to adverse reactions. On the first withdrawal I just had to stop and found that the reaction was likely to be encountered sporadically for years afterwards and it did. My GP's surgery insisted that I was mistaken and was obliged to be put on an anxiety medication.

    ?However this began a second round of treatment for which I was already prepared and I started monitoring my blood oxygen levels. These started going down, but reporting my observations was treated with ridicule.

    I got to the stage where I was feeling so out of it with nocturnal breathing difficulties that I made overnight recordings.

    ?The resulted in the composite SpO2 graph I copied to you which clearly showed that my SpO2 profile was linked to certain drug combinations in a complex manner.  I sent an adverse reaction Yellow Card report to MHRA with full supporting evidence. They contacted my GP and suggested that he and I discussed what had happened but he had already declined to treat me and has never contacted me about these adverse reactions since.

    ?The only good thing about reporting my adverse reactions to MHRA was that they appeared on my electronic patient record and when, sometime later, I was hospitalised for SVT, I was fitted with the Red Wrist Band - i.e. take more care over this patient.

    ?I've attached one of my SpO2 printouts which shows how my oxygen levels change during a recent 40 minute mild exertive walk.  My bottom graphing option shows event frequency at specific O2 levels (left) and time spent below specific O2 levels (right).  My earlier adverse reaction SpO2 printouts were more like yours are now.

    ?I think you've done enough to prove to yourself that there is a good reason why you are experiencing intolerable adverse reactions and that you have the evidence - which I reckon is more demonstrable in your SpO2 records than your ecg.

    ?I think you are definitely experiencing an excessive number of events and at too low a level of SpO2.

    ?The only thing I can think of is to find a medical professional who can interpret SpO2 recordings and conclude that your intolerable symptoms are consistent with your observations. If this a long term effect from withdrawal from bisoprolol there must be something on the internet somewhere that has addressed its treatment but it may be in medical journals which are sometimes difficult to access.



    • Posted

      I cannot believe health professionals have never encountered this when there are two of us right here, with the same experience and "anxiety" fob off.

      I did manage to get one of my GPs to address my low oxygen level before the "its anxiety" letter cane from my cardiologist, so hoping I can get them to consider further, although it is my experience they just do what has been referred to them by the GP, and nothing more.

      Tomorrow I see this Cardiologist and will give him a print of my post here to consider, and ask if he can refer me to the one specialist in England re Autonomic Neuropathy.

      Wednesday I have to go back to work as a result of that "its anxiety" letter, I anticipate that it will be a very short time before they call an ambulance from across the river at St Thomas', as they are paranoid about people dying where I work and call ambulances at the drop of a hat. But inconvenient as it is for me, at least it would give me access to more doctors that might take me seriously. 

    • Posted

      ?I just came across this Patient entry of a few years ago with many reports of longevity of withdrawal adverse reactions.

      ?Sorry if you've come across this already but there are some commenters under this thread who have large databases of extended problems with bisoprolol withdrawal.

      I'm beginning to think that this is in fact a known problem in the medical world.

      ?When I was following up reactions I had to a medications I found leads to medical publications were disappearing whilst I was doing searches.

      ?The only breakthrough I got was from an open publication on recognising early signs of heart failure.

      ?I didn't say I was a patient - you get fobbed off when you do that.

      Good Luck


    • Posted

      Yes, I am on that thread, so I just posted an update and a link to this thread, though the link needs to be checked by the mods.
    • Posted

      please tell me you are still on?! i am so lost going through same symptoms on metoprolol.. cant breathe on it and now they think I have copd at 28. Yes, I did smoke.. and now stopped. But I NEVER had breathing constrictions until this medicine

    • Edited

      Hi tara,

      Yes I am still on after grappling with the increasing security measures on Patient.

      I'm on beta blockers but then I'm in my late seventies.

      My beta blockers reduced my resting heart rate by about 20 beats per minute from about 85bpm to 65 bpm.

      I've been told by my cardiologist consultant that I need to up my dose but am in the process of self monitoring with a heart rate monitor to get some evidence as this is inappropriate.



    • Posted

      bob!!! oh bob thank you so much for replying!!! I cant breathe Bob! cannot breathe on this metoprolol ER. My cardiologist said come off, but im on it for my inappropriate sinus tachycardia... so just lowering my dose im really feeling it! My breathing started on christmas morning.. felt restricted and almost thought maybe I was trying to get a upper respitory infection, but it never came. The feeling wasnt constant then.. I have also been on metoprolol since last July but im still on the same bottle as it was a 3 month supply so if that tells you how little I was taking.. in the beginning i was only taking it every other day as it maked my BP too low. But the breathing got worse and i had a breathing test done and i was one point off of normal and the lady acted as it could be copd im 28!!! yes, i was a smoker and im ashamed to say from a young age... im now smoke free for more than 2 weeks... but i believe im short of breathe and constricted from this BB!!! i was short of breath when i was put on this same pill years ago for anxiety and fast HR in my teens from age 25. I was on metoprolol 50 mgs for ten years...went to cardiologist 6-7 months pregnant complaining of being SOB and he took me off cold turkey... i dont remember when but the breathing went back and thats why i think this is the issue again! the crazy part is i dont remember having a bad experience coming off cold turkey then, but now i have the inappropriate sinus tachycardia and im wondering if the BB caused it! ill never know! im trying to come off it again and its hard! im in hopes my breathing WILL ease up and i wont gave copd im just so scared!

    • Posted

      Hi Tara,

      The complexity of your symptoms and especially considering that you have been advised to come off beta blockers by a cardiologist makes it inadvisable for me to comment.

      It is possible that you may need to speak face to face with a local pharmacist whose job it is to approve the prescriptions written out by a GP on behalf of a consultant.

      If things are getting that bad in the next 24 hours I suggest you contact the NHS via the 111 service who will go through a checklist of your symptoms, provide advice of appropriate medical assistance and fast track any required treatment.

      Here's a link to the service and how to contact:

      Let me know how you get on.



    • Posted

      Hi Tara,

      Your first message sounded as if you could well need local emergency treatment - breathing problems are a priority in those cases and withdrawing from beta blockers only makes things worse.

      Considering that you have a lot to worry about in the current circumstances, I reckon it could well worth buying a pulse oximeter that would measure your pulse rate, the percentage oxygen in your bloodstream and also your peripheral infusion (a measure between one to twenty) that indicates how well your blood is flowing to your fingers.

      This is a low cost one approved by the NHS and available from Amazon:


      If you should ever need to consult a medical professional about a condition you are worried about then the pulse oximeter readings will help deciding a course of action.

      Bye for now


    • Posted

      I have been to the ER and the xray was clear... my oxygen stays around 97-100. I am not sure what is going on, but KNOW that I have never had breathing issues until I was put on this beta blocker. That was why I am on here and just reading what you all wrote it sounds so familiar to what I am experiencing.

    • Posted

      Hi Tara,

      It would be useful if you had what's called an interpretive ecg that is capable of generating a printout of both QT and QTc intervals together with your resting heart rate.

      This is relevant because beta blockers will cause changes in this interval and cause possibly harmful effects in younger people.



  • Posted

    Hi Peter,

    Just tried comparing our two SpO2 recordings - both nocturnal and about the same length.

    ​Mine was taken in 2012 about 2 weeks after withdrawing from a drug causing intolerable side effects.

    ​It  shows instability of both SpO2 and heart rate but I had much higher SpO2 levels and higher levels of heart rate.

    ​My SpO2 reports showed continuing deterioration at the time and caused me to withdraw from all medication.

    Yours has significantly lower SpO2 and also lower heart rate levels and I gather has been taken some time after beta-blocker withdrawal with no other medication.

    I have recently been observing that changes in my heart rate have been accompanied by compensatory changes in SpO2 when in a resting state in order to maintain steady perfusion. This would suggest that changes in both should correlate and thus events in each should correlate.

    ​Your SpO2/pulse rate event markers show far less correlation than mine - with your heart rate variability being far more in evidence than your SpO2 events.

    This is a bit of a long shot but have you considered the involvement of your carotid baroreceptors​ in failing to maintain your SpO2 levels - they are the only receptors in humans that detect low oxygen partial pressures.



    • Posted

      I was unaware of the technical term, but I did say to my cardiologist today that the Autonomic Nervous System detects blood oxygen levels and gets the breathing mechanism to react accordingly in a working ANS.

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